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    Tbcel tubulin folding cofactor E-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315591, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Tbcelprovided by RGD
    Official Full Name
    tubulin folding cofactor E-likeprovided by RGD
    Primary source
    RGD:1308880
    See related
    Ensembl:ENSRNOG00000032364 AllianceGenome:RGD:1308880
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lrrc35; RGD1308880
    Summary
    Predicted to enable alpha-tubulin binding activity. Predicted to be involved in microtubule cytoskeleton organization; post-chaperonin tubulin folding pathway; and tubulin complex assembly. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human TBCEL (tubulin folding cofactor E like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 121.2), Thymus (RPKM 91.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tbcel in Genome Data Viewer
    Location:
    8q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (51692660..51751560, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (42795648..42854552, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (46691488..46750816, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene tectorin alpha Neighboring gene uncharacterized LOC102549755 Neighboring gene uncharacterized LOC120094129

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-chaperonin tubulin folding pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tubulin complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tubulin-specific chaperone cofactor E-like protein
    Names
    leucine rich repeat containing 35
    leucine-rich repeat-containing protein 35

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014089.2 → NP_001014111.1  tubulin-specific chaperone cofactor E-like protein

      See identical proteins and their annotated locations for NP_001014111.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q5PQJ7
      UniProtKB/TrEMBL
      A0A8I5ZV57
      Related
      ENSRNOP00000083279.1, ENSRNOT00000119305.1
      Conserved Domains (4) summary
      COG4886
      Location:47 → 225
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      cd17045
      Location:337 → 422
      Ubl_TBCEL; ubiquitin-like (Ubl) domain found in tubulin-specific chaperone cofactor E-like protein (TBCEL) and similar proteins
      pfam14580
      Location:191 → 304
      LRR_9; Leucine-rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      51692660..51751560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081416.2 → XP_038937344.1  tubulin-specific chaperone cofactor E-like protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZV57, A0A8I6AFW9
      Related
      ENSRNOP00000091803.1
      Conserved Domains (4) summary
      COG4886
      Location:47 → 225
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      cd17045
      Location:380 → 465
      Ubl_TBCEL; ubiquitin-like (Ubl) domain found in tubulin-specific chaperone cofactor E-like protein (TBCEL) and similar proteins
      pfam14580
      Location:191 → 304
      LRR_9; Leucine-rich repeat

    2. XM_006242859.5 → XP_006242921.1  tubulin-specific chaperone cofactor E-like protein isoform X3

      See identical proteins and their annotated locations for XP_006242921.1

      UniProtKB/TrEMBL
      A0A8I5ZV57, A0A8L2QRT5, A6J3T2
      Related
      ENSRNOP00000056698.2
      Conserved Domains (4) summary
      COG4886
      Location:65 → 243
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:93 → 277
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:96 → 119
      LRR_RI; leucine-rich repeat [structural motif]
      cl00155
      Location:363 → 437
      UBQ; Ubiquitin-like proteins

    3. XM_039081415.2 → XP_038937343.1  tubulin-specific chaperone cofactor E-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZV57
      Conserved Domains (4) summary
      COG4886
      Location:65 → 243
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:96 → 119
      LRR_RI; leucine-rich repeat [structural motif]
      cd17045
      Location:398 → 483
      Ubl_TBCEL; ubiquitin-like (Ubl) domain found in tubulin-specific chaperone cofactor E-like protein (TBCEL) and similar proteins
      pfam14580
      Location:209 → 322
      LRR_9; Leucine-rich repeat

    4. XM_039081418.2 → XP_038937346.1  tubulin-specific chaperone cofactor E-like protein isoform X5

      Conserved Domains (2) summary
      cd17045
      Location:230 → 315
      Ubl_TBCEL; ubiquitin-like (Ubl) domain found in tubulin-specific chaperone cofactor E-like protein (TBCEL) and similar proteins
      pfam14580
      Location:41 → 154
      LRR_9; Leucine-rich repeat

    5. XM_039081417.2 → XP_038937345.1  tubulin-specific chaperone cofactor E-like protein isoform X4

      Conserved Domains (3) summary
      sd00033
      Location:96 → 119
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:209 → 322
      LRR_9; Leucine-rich repeat
      cd21340
      Location:90 → 316
      PPP1R42; protein phosphatase 1 regulatory subunit 42
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQJ7.1 GenPept UniProtKB/Swiss-Prot:Q5PQJ7

    Gene LinkOut

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