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    Tns1 tensin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301509, updated on 2-May-2024

    Summary

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    Official Symbol
    Tns1provided by RGD
    Official Full Name
    tensin 1provided by RGD
    Primary source
    RGD:68427
    See related
    Ensembl:ENSRNOG00000014182 AllianceGenome:RGD:68427
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tns
    Summary
    Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within cell-substrate junction assembly and fibroblast migration. Predicted to be located in focal adhesion. Orthologous to human TNS1 (tensin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 927.0), Heart (RPKM 881.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tns1 in Genome Data Viewer
    Location:
    9q33
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (82941068..83152007, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (75491886..75702853, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (81190192..81401020, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC134480593 Neighboring gene uncharacterized LOC134480594 Neighboring gene ribosomal protein S21, pseudogene 7 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene C-X-C motif chemokine receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration. Chen H, et al. Proc Natl Acad Sci U S A, 2002 Jan 22. PMID 11792844, Free PMC Article
    2. Progressive kidney degeneration in mice lacking tensin. Lo SH, et al. J Cell Biol, 1997 Mar 24. PMID 9087448, Free PMC Article
    3. Molecular characterization of human tensin. Chen H, et al. Biochem J, 2000 Oct 15. PMID 11023826, Free PMC Article
    4. Genes for tensin, villin and desmin are linked on mouse chromosome 1. Jankowski SA, et al. Mamm Genome, 1995 Oct. PMID 8563175
    5. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell-substrate junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fibroblast migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell-substrate junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tensin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191810.3 → NP_001178739.1  tensin-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5Y194
      Related
      ENSRNOP00000091650.1, ENSRNOT00000097211.1
      Conserved Domains (5) summary
      cd09927
      Location:1633 → 1748
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:250 → 365
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd00029
      Location:75 → 108
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01213
      Location:1770 → 1903
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:352 → 478
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      82941068..83152007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083336.2 → XP_038939264.1  tensin-1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5Y194, A0A8I6A4G0
      Related
      ENSRNOP00000087478.1
      Conserved Domains (6) summary
      cd09927
      Location:1612 → 1727
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:1053 → 1582
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1749 → 1882
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:352 → 478
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cd20888
      Location:57 → 112
      C1_TNS1_v; protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar proteins
      cl28904
      Location:187 → 345
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. XM_063266966.1 → XP_063123036.1  tensin-1 isoform X5

    3. XM_063266965.1 → XP_063123035.1  tensin-1 isoform X4

    4. XM_039083330.2 → XP_038939258.1  tensin-1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y194
      Conserved Domains (6) summary
      cd09927
      Location:1661 → 1776
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:1091 → 1643
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1798 → 1931
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:352 → 478
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cd20888
      Location:57 → 112
      C1_TNS1_v; protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar proteins
      cl28904
      Location:187 → 345
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    5. XM_039083335.2 → XP_038939263.1  tensin-1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y194
      Related
      ENSRNOP00000077508.1
      Conserved Domains (6) summary
      cd09927
      Location:1620 → 1735
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:1045 → 1602
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1757 → 1890
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:311 → 437
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cd20888
      Location:16 → 71
      C1_TNS1_v; protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar proteins
      cl28904
      Location:146 → 304
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    6. XM_039083352.2 → XP_038939280.1  tensin-1 isoform X10

      UniProtKB/TrEMBL
      F1LN42
      Related
      ENSRNOP00000032812.6
      Conserved Domains (5) summary
      cd09927
      Location:1511 → 1626
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:941 → 1493
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1648 → 1781
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:202 → 328
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:37 → 195
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    7. XM_039083349.2 → XP_038939277.1  tensin-1 isoform X10

      UniProtKB/TrEMBL
      F1LN42
      Conserved Domains (5) summary
      cd09927
      Location:1511 → 1626
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:941 → 1493
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1648 → 1781
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:202 → 328
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:37 → 195
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    8. XM_039083341.2 → XP_038939269.2  tensin-1 isoform X10

    9. XM_063266971.1 → XP_063123041.1  tensin-1 isoform X16

    10. XM_039083348.2 → XP_038939276.2  tensin-1 isoform X15

    11. XM_039083346.2 → XP_038939274.2  tensin-1 isoform X13

    12. XM_039083347.2 → XP_038939275.2  tensin-1 isoform X14

    13. XM_063266969.1 → XP_063123039.1  tensin-1 isoform X12

    14. XM_039083344.2 → XP_038939272.2  tensin-1 isoform X11

    15. XM_063266968.1 → XP_063123038.1  tensin-1 isoform X9

    16. XM_063266967.1 → XP_063123037.1  tensin-1 isoform X8

    17. XM_063266963.1 → XP_063123033.1  tensin-1 isoform X2

    18. XM_063266962.1 → XP_063123032.1  tensin-1 isoform X1

    19. XM_039083351.2 → XP_038939279.1  tensin-1 isoform X10

      UniProtKB/TrEMBL
      F1LN42
      Conserved Domains (5) summary
      cd09927
      Location:1511 → 1626
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:941 → 1493
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1648 → 1781
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:202 → 328
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:37 → 195
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    20. XM_039083350.2 → XP_038939278.1  tensin-1 isoform X10

      UniProtKB/TrEMBL
      F1LN42
      Conserved Domains (5) summary
      cd09927
      Location:1511 → 1626
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:941 → 1493
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1648 → 1781
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:202 → 328
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:37 → 195
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    21. XM_063266972.1 → XP_063123042.1  tensin-1 isoform X17

    Nucleotide Protein Strain
    Heading Accession and Version

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