BMP7 bone morphogenetic protein 7 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: BMP7provided by VGNC
Official Full Name: bone morphogenetic protein 7provided by VGNC
Primary source: VGNC:VGNC:38482
See related: Ensembl:ENSCAFG00845029691
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: OP-1; BMP-7
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	24	NC_051828.1 (43068237..43159868, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	24	NC_006606.4 (41452207..41541996, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	24	NC_049245.1 (42952879..43042732, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	24	NC_049284.1 (42155146..42244886, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	24	NC_049765.1 (42294769..42384624, complement)

Chromosome 24 - NC_051828.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Both quantitative reverse-transcriptase PCR and Western blotting showed up-regulated BMP-7 signalling in kidneys of congenital portosystemic shunt -affected dogs.
Title: Increased bone morphogenetic protein 7 signalling in the kidneys of dogs affected with a congenital portosystemic shunt.
Studies identify YB1 as a transcriptional activator of BMP7 and helps to explain the progressive decline in renal BMP7 in diabetic nephropathy and other kidney diseases.
Title: Y-box protein-1 is a transcriptional regulator of BMP7.

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General gene information

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Markers

BMP7 (e-PCR)
- UniSTS:262742

Bmp7 (e-PCR), detects polymorphism
- UniSTS:474744

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: bone morphogenetic protein 7

Names: osteogenic protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001197052.1 → NP_001183981.1 bone morphogenetic protein 7 precursor

Status: VALIDATED

Source sequence(s)

JAAUVH010000376

UniProtKB/TrEMBL

A0A8I3Q4D7

Conserved Domains (2) summary

smart00204
Location:332 → 433

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:34 → 281

TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051828.1 Reference ROS_Cfam_1.0

Range

43068237..43159868 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038432820.1 → XP_038288748.1 bone morphogenetic protein 7 isoform X3

UniProtKB/TrEMBL

A0A8I3Q4D7, A0A8I3Q790

Related

ENSCAFP00845041326.1, ENSCAFT00845052655.1

Conserved Domains (2) summary

cd19397
Location:259 → 365

TGF_beta_BMP7; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins

pfam00688
Location:35 → 253

TGFb_propeptide; TGF-beta propeptide
XM_038432818.1 → XP_038288746.1 bone morphogenetic protein 7 isoform X1

UniProtKB/TrEMBL

A0A8I3Q4D7

Related

ENSCAFP00845041310.1, ENSCAFT00845052637.1

Conserved Domains (2) summary

cd19397
Location:325 → 431

TGF_beta_BMP7; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins

pfam00688
Location:35 → 280

TGFb_propeptide; TGF-beta propeptide
XM_038432819.1 → XP_038288747.1 bone morphogenetic protein 7 isoform X2

UniProtKB/TrEMBL

A0A8I3Q2D3

Related

ENSCAFP00845041380.1, ENSCAFT00845052717.1

Conserved Domains (1) summary

pfam00688
Location:35 → 280

TGFb_propeptide; TGF-beta propeptide