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    dnajb1b DnaJ heat shock protein family (Hsp40) member B1b [ Danio rerio (zebrafish) ]

    Gene ID: 327244, updated on 27-Mar-2024

    Summary

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    Official Symbol
    dnajb1bprovided by ZNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5455
    See related
    Ensembl:ENSDARG00000041394 AllianceGenome:ZFIN:ZDB-GENE-030131-5455
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dnj-13C; fd19c10; zgc:55492; wu:fd19c10; CH73-341P18.4
    Summary
    Predicted to enable several functions, including Hsp70 protein binding activity; chaperone binding activity; and unfolded protein binding activity. Acts upstream of or within lens development in camera-type eye. Predicted to be active in cytosol. Is expressed in lens; neural plate; optic tectum; and solid lens vesicle. Orthologous to human DNAJB1 (DnaJ heat shock protein family (Hsp40) member B1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (55745878..55749997, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (55068227..55072346, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909388 Neighboring gene putative adhesion G protein-coupled receptor E4P Neighboring gene adhesion G protein-coupled receptor E10 Neighboring gene trans-2,3-enoyl-CoA reductase b Neighboring gene uncharacterized LOC101884156 Neighboring gene NADH:ubiquinone oxidoreductase subunit B7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of fibrolamellar carcinoma. de Oliveira S, et al. Dis Model Mech, 2020 Apr 30. PMID 32102783, Free PMC Article
    2. Lysyl hydroxylase 3 is required for normal lens capsule formation and maintenance of lens epithelium integrity and fate. Taler K, et al. Dev Biol, 2020 Feb 15. PMID 31669351
    3. FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1. Khan SY, et al. Nat Commun, 2016 Apr 6. PMID 27218149, Free PMC Article
    4. Transcriptomic profile of early zebrafish PGCs by single cell sequencing. Zhang X, et al. PLoS One, 2019. PMID 31412047, Free PMC Article
    5. The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Hawkins TA, et al. Development, 2008 Mar. PMID 18256191, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lens development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily B member 1b
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 1
    DnaJ (Hsp40) homolog, subfamily B, member 1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199773.1 → NP_956067.1  dnaJ homolog subfamily B member 1b

      See identical proteins and their annotated locations for NP_956067.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045359
      UniProtKB/TrEMBL
      Q7ZVY8
      Related
      ENSDARP00000121420.2, ENSDART00000142244.3
      Conserved Domains (3) summary
      cd10747
      Location:160 → 322
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:1 → 328
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:4 → 65
      DnaJ; DnaJ domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      55745878..55749997 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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