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    ZNF174 zinc finger protein 174 [ Homo sapiens (human) ]

    Gene ID: 7727, updated on 5-May-2024

    Summary

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    Official Symbol
    ZNF174provided by HGNC
    Official Full Name
    zinc finger protein 174provided by HGNC
    Primary source
    HGNC:HGNC:12963
    See related
    Ensembl:ENSG00000103343 MIM:603900; AllianceGenome:HGNC:12963
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZSCAN8
    Summary
    This gene encodes a protein with three Cys2-His2-type zinc fingers in the carboxy-terminus, a putative nuclear localization signal, and an amino-terminus SCAN box which forms homodimers. This protein is believed to function as a transcriptional repressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016]
    Expression
    Ubiquitous expression in ovary (RPKM 4.6), testis (RPKM 4.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    16p13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3401215..3409364)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3428486..3436629)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3451215..3459364)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371059 Neighboring gene MT-RNR2 like 4 (pseudogene) Neighboring gene zinc finger and SCAN domain containing 32 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3450765-3451264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7133 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3470303-3470585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3481451-3481952 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7134 Neighboring gene zinc finger protein 597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10322 Neighboring gene N-alpha-acetyltransferase 60, NatF catalytic subunit Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7135 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_43328 and experimental_43330 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43334 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43335 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3517275-3517812 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3519547-3520264 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43345 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43346 Neighboring gene microRNA 6126

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The SCAN domain of ZNF174 is a dimer. Stone JR, et al. J Biol Chem, 2002 Feb 15. PMID 11741982, Free PMC Article
    2. Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain. Ivanov D, et al. Mol Cell, 2005 Jan 7. PMID 15629724
    3. Isolation and characterization of a novel zinc-finger protein with transcription repressor activity. Williams AJ, et al. J Biol Chem, 1995 Sep 22. PMID 7673192
    4. Heterodimer formation of the myeloid zinc finger 1 SCAN domain and association with promyelocytic leukemia nuclear bodies. Noll L, et al. Leuk Res, 2008 Oct. PMID 18472161
    5. The zinc finger-associated SCAN box is a conserved oligomerization domain. Williams AJ, et al. Mol Cell Biol, 1999 Dec. PMID 10567577, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: NAA60

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 174
    Names
    AW-1
    zinc finger and SCAN domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053015.1 RefSeqGene

      Range
      5026..13175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001032292.3 → NP_001027463.1  zinc finger protein 174 isoform b

      See identical proteins and their annotated locations for NP_001027463.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternative 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (b) with a different C-terminus compared to isoform a.
      Source sequence(s)
      AC025283, BC001161, BI918471, DA962432
      Consensus CDS
      CCDS32380.1
      UniProtKB/TrEMBL
      Q8IZN5
      Related
      ENSP00000339781.5, ENST00000344823.9
      Conserved Domains (1) summary
      smart00431
      Location:42 → 152
      SCAN; leucine rich region

    2. NM_001347868.2 → NP_001334797.1  zinc finger protein 174 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a segment of the 5' UTR, compared to transcript variant 1, but encodes the same isoform (a).
      Source sequence(s)
      AC025283, BM969505
      Consensus CDS
      CCDS10504.1
      UniProtKB/Swiss-Prot
      Q15697, Q53Y68, Q9BQ34
      Related
      ENSP00000460397.1, ENST00000571936.5

    3. NM_001347869.2 → NP_001334798.1  zinc finger protein 174 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternative 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (c) with a different C-terminus compared to isoform a.
      Source sequence(s)
      AC025283
      Consensus CDS
      CCDS86501.1
      UniProtKB/TrEMBL
      I3L2H2, Q8IZN5
      Related
      ENSP00000459681.1, ENST00000572544.1

    4. NM_001347870.2 → NP_001334799.1  zinc finger protein 174 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks a segment of the 5' UTR and contains an alternative 3' terminal exon, compared to transcript variant 1, resulting in a shorter isoform (c) with a different C-terminus compared to isoform a.
      Source sequence(s)
      AC025283
      Consensus CDS
      CCDS86501.1
      UniProtKB/TrEMBL
      I3L2H2, Q8IZN5

    5. NM_003450.3 → NP_003441.1  zinc finger protein 174 isoform a

      See identical proteins and their annotated locations for NP_003441.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC025283, BI918471, BM969505, DA962432, U31248
      Consensus CDS
      CCDS10504.1
      UniProtKB/Swiss-Prot
      Q15697, Q53Y68, Q9BQ34
      Related
      ENSP00000268655.4, ENST00000268655.5
      Conserved Domains (6) summary
      smart00431
      Location:42 → 152
      SCAN; leucine rich region
      COG5048
      Location:352 → 407
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:328 → 348
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:326 → 348
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:42 → 130
      SCAN; SCAN domain
      pfam13465
      Location:369 → 393
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      3401215..3409364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      3428486..3436629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15697.1 GenPept UniProtKB/Swiss-Prot:Q15697

    Gene LinkOut

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