GPR132 G protein-coupled receptor 132 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPR132provided by HGNC
Official Full Name: G protein-coupled receptor 132provided by HGNC
Primary source: HGNC:HGNC:17482
See related: Ensembl:ENSG00000183484 MIM:606167; AllianceGenome:HGNC:17482
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: G2A
Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression: Broad expression in appendix (RPKM 4.0), lymph node (RPKM 3.6) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q32.33

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (105049395..105065430, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (99293953..99309986, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (105515732..105531767, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia.
Title: Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia.
Lipid Receptor G2A-Mediated Signal Pathway Plays a Critical Role in Inflammatory Response by Promoting Classical Macrophage Activation.
Title: Lipid Receptor G2A-Mediated Signal Pathway Plays a Critical Role in Inflammatory Response by Promoting Classical Macrophage Activation.
Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors.
Title: Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors.
G protein-coupled receptor 132 (Gpr132) functions as a key macrophage sensor of the rising lactate in the acidic tumor milieu to mediate the reciprocal interaction between cancer cells and macrophages during breast cancer metastasis. Lactate activates macrophage Gpr132 to promote the alternatively activated macrophage (M2)-like phenotype, which, in turn, facilitates cancer cell adhesion, migration, and invasion.
Title: Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis.
High GPR132 expression is associated with acute lymphoblastic leukemia.
Title: Direct interaction of Ikaros and Foxp1 modulates expression of the G protein-coupled receptor G2A in B-lymphocytes and acute lymphoblastic leukemia.
coexpression of OGR1- and G2A-enhanced proton sensitivity and proton-induced calcium signals. This alteration is attributed to oligomerization of OGR1 and G2A. The oligomeric potential locates receptors at a specific site, which leads to enhanced
Title: Heteromerization of G2A and OGR1 enhances proton sensitivity and proton-induced calcium signals.
Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator)
Title: Integrative predictive model of coronary artery calcification in atherosclerosis.
we found an additional novel G2A variant (G2A-b) that is the major transcript with functional response to ligand stimulation as well as G2A-a, and succeeded in discriminating proton-sensing and oxidized fatty acid-sensing activities of G2A.
Title: Identification and analysis of two splice variants of human G2A generated by alternative splicing.
9-HODE-G2A signaling plays proinflammatory roles in skin under oxidative conditions
Title: G2A plays proinflammatory roles in human keratinocytes under oxidative stress as a receptor for 9-hydroxyoctadecadienoic acid.
the G-protein-coupled receptor G2A, unlike its relative GPR4, is involved in the chemotaxis of monocytic cells.
Title: Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

G36142 (e-PCR)
- UniSTS:22051

G36117 (e-PCR)
- UniSTS:44631

GPR132_1771 (e-PCR)
- UniSTS:280708

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: probable G-protein coupled receptor 132

Names: G2 accumulation protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278694.2 → NP_001265623.1 probable G-protein coupled receptor 132 isoform 1

See identical proteins and their annotated locations for NP_001265623.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AK292142, BC084546

Consensus CDS

CCDS9997.1

UniProtKB/Swiss-Prot

A8K7X7, B4E144, Q9BSU2, Q9UNW8

UniProtKB/TrEMBL

B2LM89

Related

ENSP00000438094.2, ENST00000539291.6

Conserved Domains (1) summary

cd15364
Location:43 → 319

7tmA_GPR132_G2A; proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001278695.2 → NP_001265624.1 probable G-protein coupled receptor 132 isoform 2

See identical proteins and their annotated locations for NP_001265624.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and shorter N-terminus compared to isoform 1.

Source sequence(s)

AA714520, AB465600

Consensus CDS

CCDS61567.1

UniProtKB/TrEMBL

B2LM89

Related

ENSP00000376364.2, ENST00000392585.2

Conserved Domains (1) summary

pfam00001
Location:85 → 299

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_001278696.2 → NP_001265625.1 probable G-protein coupled receptor 132 isoform 3

See identical proteins and their annotated locations for NP_001265625.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

BC084546, DB137292

UniProtKB/Swiss-Prot

Q9UNW8

Conserved Domains (1) summary

pfam00001
Location:16 → 120

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_013345.4 → NP_037477.1 probable G-protein coupled receptor 132 isoform 1

See identical proteins and their annotated locations for NP_037477.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AA714520, AB465599

Consensus CDS

CCDS9997.1

UniProtKB/Swiss-Prot

A8K7X7, B4E144, Q9BSU2, Q9UNW8

UniProtKB/TrEMBL

B2LM89

Related

ENSP00000328818.3, ENST00000329797.8

Conserved Domains (1) summary

cd15364
Location:43 → 319

7tmA_GPR132_G2A; proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors