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    daf-9 3-ketosteroid oxygenase;Cytochrome P450 [ Caenorhabditis elegans ]

    Gene ID: 180889, updated on 12-Jun-2024

    Summary

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    Gene symbol
    daf-9
    Gene description
    3-ketosteroid oxygenase;Cytochrome P450
    Locus tag
    CELE_T13C5.1
    See related
    AllianceGenome:WB:WBGene00000905
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Involved in cell-cell signaling; dauer larval development; and regulation of cell migration. Located in neuronal cell body and perinuclear region of cytoplasm. Is expressed in several structures, including anterior ganglion; excretory cell; head neurons; spermatheca; and vulval muscle. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See daf-9 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (6196927..6200823)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene Homeobox domain-containing protein Neighboring gene Beta carbonic anhydrase 1 Neighboring gene Mitochondrial fission process protein 1 Neighboring gene Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dafachronic acid inhibits C. elegans germ cell proliferation in a DAF-12-dependent manner. Mukherjee M, et al. Dev Biol, 2017 Dec 15. PMID 29066181, Free PMC Article
    2. Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. Luciani GM, et al. Nat Chem Biol, 2011 Nov 6. PMID 22057127
    3. Regulation of the longevity response to temperature by thermosensory neurons in Caenorhabditis elegans. Lee SJ, et al. Curr Biol, 2009 May 12. PMID 19375320, Free PMC Article
    4. Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor. Sharma KK, et al. Mol Endocrinol, 2009 May. PMID 19196833, Free PMC Article
    5. Daphnia Halloween genes that encode cytochrome P450s mediating the synthesis of the arthropod molting hormone: evolutionary implications. Rewitz KF, et al. BMC Evol Biol, 2008 Feb 25. PMID 18298845, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of DAF-9 is increased in C. elegans subjected to dietary restriction.
      Title: Steroid hormone signalling links reproduction to lifespan in dietary-restricted Caenorhabditis elegans.
    2. Results altogether suggest that circulatory mutual regulation among daf-9, daf-12, and daf-16 at the expression level mediates cholesterol signal to control larval development upon cholesterol starvation.
      Title: A circulatory transcriptional regulation among daf-9, daf-12, and daf-16 mediates larval development upon cholesterol starvation in Caenorhabditis elegans.
    3. We propose that the dauer rescuing activity is a hormone synthesized by DAF-9 that acts through DAF-12.
      Title: Lipophilic regulator of a developmental switch in Caenorhabditis elegans.
    4. results support the hypothesis that ncr-1 and ncr-2 are involved in intracellular cholesterol processing in C. elegans, and that a sterol-signaling defect is responsible for the Daf-c phenotype of the ncr-2; ncr-1 mutant
      Title: NCR-1 and NCR-2, the C. elegans homologs of the human Niemann-Pick type C1 disease protein, function upstream of DAF-9 in the dauer formation pathways.
    5. We identified two distinct 3-keto-cholestenoic acid metabolites of DAF-9, a cytochrome P450 involved in hormone production, that function as ligands for DAF-12.
      Title: Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables steroid hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-ketosteroid oxygenase;Cytochrome P450
    NP_001024903.1
    • Confirmed by transcript evidence
    NP_001362132.1
    • Confirmed by transcript evidence
    NP_741807.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6196927..6200823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171699.6 → NP_741807.2  3-ketosteroid oxygenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741807.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECA9, H2KYS3
      Conserved Domains (1) summary
      pfam00067
      Location:108 → 559
      p450; Cytochrome P450

    2. NM_001029732.3 → NP_001024903.1  3-ketosteroid oxygenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024903.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2KYS3
      Conserved Domains (1) summary
      pfam00067
      Location:93 → 544
      p450; Cytochrome P450

    3. NM_001375044.2 → NP_001362132.1  Cytochrome P450 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5E4M3J0
      Conserved Domains (1) summary
      pfam00067
      Location:72 → 523
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H2KYS3.1

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