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    evl-20 ADP-ribosylation factor-like protein 2 [ Caenorhabditis elegans ]

    Gene ID: 191632, updated on 11-Apr-2024

    Summary

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    Gene symbol
    evl-20
    Gene description
    ADP-ribosylation factor-like protein 2
    Primary source
    WormBase:WBGene00001358
    Locus tag
    CELE_F22B5.1
    See related
    AllianceGenome:WB:WBGene00001358
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTP binding activity. Involved in several processes, including cortical microtubule organization; female genitalia development; and mitotic cytokinesis. Located in cytoplasm; microtubule cytoskeleton; and plasma membrane. Is expressed in several structures, including P3.p hermaphrodite; hermaphrodite gonad; hypodermis; proctodeum; and vulval cell. Orthologous to human ARL2 (ADP ribosylation factor like GTPase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003280.10 (8444307..8445177)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene LIPaSe related Neighboring gene Eukaryotic translation initiation factor 3 subunit G Neighboring gene Cuticlin-3 Neighboring gene Mitochondrial cytochrome c oxidase subunit VIa Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DUF1248 domain-containing protein Neighboring gene Serpentine Receptor, class J

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Systematic functional analysis of the Ras GTPase family unveils a conserved network required for anterograde protein trafficking. Caruso ME, et al. Proteomics, 2017 Jan. PMID 27957805
    2. Functional genomic analysis of the ADP-ribosylation factor family of GTPases: phylogeny among diverse eukaryotes and function in C. elegans. Li Y, et al. FASEB J, 2004 Dec. PMID 15576487
    3. The C. elegans evl-20 gene is a homolog of the small GTPase ARL2 and regulates cytoskeleton dynamics during cytokinesis and morphogenesis. Antoshechkin I, et al. Dev Cell, 2002 May. PMID 12015966
    4. Sticky worms: adhesion complexes in C. elegans. Cox EA, et al. J Cell Sci, 2004 Apr 15. PMID 15090594
    5. Isolation and characterization of mutations causing abnormal eversion of the vulva in Caenorhabditis elegans. Seydoux G, et al. Dev Biol, 1993 Jun. PMID 8500652

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cortical microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in aster IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like protein 2
    NP_495779.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8444307..8445177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063378.4 → NP_495779.1  ADP-ribosylation factor-like protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495779.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19705
      Conserved Domains (2) summary
      cd04154
      Location:3 → 175
      Arl2; Arf-like 2 (Arl2) GTPase
      pfam00071
      Location:18 → 172
      Ras; Ras family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19705.2

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