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    SRSF10 serine and arginine rich splicing factor 10 [ Homo sapiens (human) ]

    Gene ID: 10772, updated on 5-May-2024

    Summary

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    Official Symbol
    SRSF10provided by HGNC
    Official Full Name
    serine and arginine rich splicing factor 10provided by HGNC
    Primary source
    HGNC:HGNC:16713
    See related
    Ensembl:ENSG00000188529 MIM:605221; AllianceGenome:HGNC:16713
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NSSR; TASR; SRp38; TASR1; TASR2; FUSIP1; FUSIP2; SFRS13; SRrp40; SFRS13A; PPP1R149
    Summary
    This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Expression
    Ubiquitous expression in bone marrow (RPKM 28.7), lymph node (RPKM 12.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1p36.11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (23964347..23980327, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (23801766..23817752, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24290837..24306817, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903877 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:24275932-24276152 Neighboring gene H3 histone pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24284548-24285176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 385 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 386 Neighboring gene proline rich nuclear receptor coactivator 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24306044-24307034 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24307035-24308025 Neighboring gene uncharacterized LOC105378615 Neighboring gene ribosomal protein L36 pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SRSF10 stabilizes CDC25A by triggering exon 6 skipping to promote hepatocarcinogenesis. Liu X, et al. J Exp Clin Cancer Res, 2022 Dec 20. PMID 36539837, Free PMC Article
    2. Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production. Chabrolles H, et al. PLoS Pathog, 2020 Nov. PMID 33180834, Free PMC Article
    3. SRSF10 inhibits biogenesis of circ-ATXN1 to regulate glioma angiogenesis via miR-526b-3p/MMP2 pathway. Liu X, et al. J Exp Clin Cancer Res, 2020 Jun 29. PMID 32600379, Free PMC Article
    4. SRSF10 Connects DNA Damage to the Alternative Splicing of Transcripts Encoding Apoptosis, Cell-Cycle Control, and DNA Repair Factors. Shkreta L, et al. Cell Rep, 2016 Nov 15. PMID 27851963, Free PMC Article
    5. Heat shock-induced SRSF10 dephosphorylation displays thermotolerance mediated by Hsp27. Shi Y, et al. Mol Cell Biol, 2011 Feb. PMID 21135127, Free PMC Article

    See all (131) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of SRSF10 as a promising prognostic biomarker with functional significance among SRSFs for glioma.
      Title: Identification of SRSF10 as a promising prognostic biomarker with functional significance among SRSFs for glioma.
    2. lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy, leading to atherogenesis.
      Title: lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy, leading to atherogenesis.
    3. SRSF10 stabilizes CDC25A by triggering exon 6 skipping to promote hepatocarcinogenesis.
      Title: SRSF10 stabilizes CDC25A by triggering exon 6 skipping to promote hepatocarcinogenesis.
    4. The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma.
      Title: The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma.
    5. Identification of SRSF10 as a regulator of SMN2 ISS-N1.
      Title: Identification of SRSF10 as a regulator of SMN2 ISS-N1.
    6. Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression.
      Title: Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression.
    7. SRSF10 inhibits biogenesis of circ-ATXN1 to regulate glioma angiogenesis via miR-526b-3p/MMP2 pathway.
      Title: SRSF10 inhibits biogenesis of circ-ATXN1 to regulate glioma angiogenesis via miR-526b-3p/MMP2 pathway.
    8. Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production.
      Title: Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production.
    9. Moreover, SRSF10, hnRNP A1/A2 and Sam68 collaborate to drive the DNA damage-induced splicing response of several transcripts that produce components implicated in apoptosis, cell-cycle control and DNA repair.
      Title: hnRNP A1/A2 and Sam68 collaborate with SRSF10 to control the alternative splicing response to oxaliplatin-mediated DNA damage.
    10. DNA damage co-opts SRSF10 to control splicing decisions in transcripts encoding components involved in DNA repair, cell-cycle control, and apoptosis.
      Title: SRSF10 Connects DNA Damage to the Alternative Splicing of Transcripts Encoding Apoptosis, Cell-Cycle Control, and DNA Repair Factors.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 10 (SRSF10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 10 (SRSF10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 10 (SRSF10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify serine/arginine-rich splicing factor 10 (SRSF10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Tat tat Expression of HIV-1 Tat upregulates the abundance of serine/arginine-rich splicing factor 10 (SRSF10, FUSIP1) in the nucleoli of Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ30749, FLJ43846, DKFZp686H0644

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables RS domain binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables unfolded protein binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing, via transesterification reactions IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytosolic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splice site recognition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spliceosomal tri-snRNP complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon terminus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/arginine-rich splicing factor 10
    Names
    40 kDa SR-repressor protein
    FUS interacting protein (serine-arginine rich) 1
    FUS-interacting protein (serine-arginine rich) 2
    SR splicing factor 10
    TLS-associated SR protein
    TLS-associated protein TASR
    TLS-associated protein with SR repeats
    TLS-associated protein with Ser-Arg repeats
    TLS-associated serine-arginine protein 1
    TLS-associated serine-arginine protein 2
    neural-salient SR protein
    protein phosphatase 1, regulatory subunit 149
    serine-arginine repressor protein (40 kDa)
    splicing factor SRp38
    splicing factor, arginine/serine-rich 13
    splicing factor, arginine/serine-rich 13A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191005.3 → NP_001177934.1  serine/arginine-rich splicing factor 10 isoform 3

      See identical proteins and their annotated locations for NP_001177934.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site, compared to variant 2. The encoded isoform (3) is shorter than isoform 2.
      Source sequence(s)
      AK001656, AL590609
      Consensus CDS
      CCDS53282.1
      UniProtKB/TrEMBL
      Q53GD7
      Related
      ENSP00000344149.4, ENST00000343255.9
      Conserved Domains (1) summary
      cl17169
      Location:5 → 99
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001191006.3 → NP_001177935.1  serine/arginine-rich splicing factor 10 isoform 4

      See identical proteins and their annotated locations for NP_001177935.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 2.
      Source sequence(s)
      AK093226, AL590609, BC010074
      Consensus CDS
      CCDS53283.1
      UniProtKB/Swiss-Prot
      O75494
      Related
      ENSP00000363576.5, ENST00000374452.9
      Conserved Domains (1) summary
      cl17169
      Location:5 → 99
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001191007.3 → NP_001177936.1  serine/arginine-rich splicing factor 10 isoform 5

      See identical proteins and their annotated locations for NP_001177936.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site and lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (5) has a distinct C-terminus and is shorter than isoform 2.
      Source sequence(s)
      AK093226, AL590609, AY007101
      Consensus CDS
      CCDS53281.1
      UniProtKB/Swiss-Prot
      O75494
      Related
      ENSP00000388991.3, ENST00000453840.7
      Conserved Domains (1) summary
      cl17169
      Location:5 → 99
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_001191009.3 → NP_001177938.1  serine/arginine-rich splicing factor 10 isoform 6

      See identical proteins and their annotated locations for NP_001177938.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (6) has a distinct C-terminus and is shorter than isoform 2.
      Source sequence(s)
      AK296175, AL590609, AY007101
      Consensus CDS
      CCDS53280.1
      UniProtKB/Swiss-Prot
      O75494
      Related
      ENSP00000419813.2, ENST00000484146.6
      Conserved Domains (1) summary
      cd12559
      Location:5 → 99
      RRM_SRSF10; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 10 (SRSF10) and similar proteins

    5. NM_001300936.2 → NP_001287865.1  serine/arginine-rich splicing factor 10 isoform 8

      See identical proteins and their annotated locations for NP_001287865.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses an alternate in-frame splice site and lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (8) has a distinct C-terminus and is shorter than isoform 2.
      Source sequence(s)
      AL590609
      Consensus CDS
      CCDS72728.1
      UniProtKB/TrEMBL
      Q5JRI1
      Related
      ENSP00000363577.3, ENST00000374453.7
      Conserved Domains (1) summary
      cl17169
      Location:10 → 93
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. NM_001300937.2 → NP_001287866.1  serine/arginine-rich splicing factor 10 isoform 9

      See identical proteins and their annotated locations for NP_001287866.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (9) has a distinct C-terminus and is shorter than isoform 2.
      Source sequence(s)
      AL590609
      Conserved Domains (1) summary
      cl17169
      Location:5 → 99
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. NM_006625.6 → NP_006616.1  serine/arginine-rich splicing factor 10 isoform 1

      See identical proteins and their annotated locations for NP_006616.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (1) has a distinct C-terminus and is shorter than isoform 2.
      Source sequence(s)
      AF419331, AL590609
      Consensus CDS
      CCDS30629.1
      UniProtKB/Swiss-Prot
      O75494
      Related
      ENSP00000342913.5, ENST00000344989.10
      Conserved Domains (1) summary
      cd12559
      Location:5 → 99
      RRM_SRSF10; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 10 (SRSF10) and similar proteins

    8. NM_054016.4 → NP_473357.1  serine/arginine-rich splicing factor 10 isoform 2

      See identical proteins and their annotated locations for NP_473357.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
      Source sequence(s)
      AK093226, AL590609, BC005039
      Consensus CDS
      CCDS30630.1
      UniProtKB/Swiss-Prot
      A6NFM6, A6NI42, A6NIU7, B4DJP9, O60572, O75494, Q5JRH9, Q5JRI0, Q5JRI2, Q5JRI3, Q5JRI4, Q96G09, Q96P17
      UniProtKB/TrEMBL
      A0A0S2Z504, Q53GD7
      Related
      ENSP00000420195.1, ENST00000492112.3
      Conserved Domains (1) summary
      cl17169
      Location:5 → 99
      RRM_SF; RNA recognition motif (RRM) superfamily

    RNA

    1. NR_034035.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) contains multiple differences at both the 5' and 3' ends, compared to variant 2. This variant is represented as non-coding because the longest in-frame ORF does not meet RefSeq quality criteria.
      Source sequence(s)
      AK093226, AL590609, AY007101

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      23964347..23980327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000102.3 → XP_016855591.1  serine/arginine-rich splicing factor 10 isoform X1

      UniProtKB/TrEMBL
      B3KNY6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      23801766..23817752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333940.1 → XP_054189915.1  serine/arginine-rich splicing factor 10 isoform X1

      UniProtKB/TrEMBL
      B3KNY6

    2. XM_054333939.1 → XP_054189914.1  serine/arginine-rich splicing factor 10 isoform X1

      UniProtKB/TrEMBL
      B3KNY6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75494.1 GenPept UniProtKB/Swiss-Prot:O75494

    Gene LinkOut

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