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    CG11313 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43646, updated on 10-May-2024

    Summary

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    Official Symbol
    CG11313provided by FlyBase
    Primary source
    FLYBASE:FBgn0039798
    Locus tag
    Dmel_CG11313
    See related
    AllianceGenome:FB:FBgn0039798
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c-SP11; cSP11; Dmel\CG11313; SP11
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG11313 in Genome Data Viewer
    Location:
    100A3-100A3; 3-101 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30729837..30731165, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26555559..26556887, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46219 Neighboring gene eukaryotic translation initiation factor 4H2 Neighboring gene uncharacterized protein Neighboring gene Niemann-Pick type C-2g

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic evidence of a redox-dependent systemic wound response via Hayan protease-phenoloxidase system in Drosophila. Nam HJ, et al. EMBO J, 2012 Mar 7. PMID 22227521, Free PMC Article
    2. Population- and sex-biased gene expression in the excretion organs of Drosophila melanogaster. Huylmans AK, et al. G3 (Bethesda), 2014 Sep 22. PMID 25246242, Free PMC Article
    3. Drosophila melanogaster clip-domain serine proteases: Structure, function and regulation. Veillard F, et al. Biochimie, 2016 Mar. PMID 26453810
    4. Proteomic analysis of the Drosophila larval hemolymph clot. Karlsson C, et al. J Biol Chem, 2004 Dec 10. PMID 15466469
    5. Infection Dynamics and Immune Response in a Newly Described Drosophila-Trypanosomatid Association. Hamilton PT, et al. mBio, 2015 Sep 15. PMID 26374124, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11313-PC
    CG11313-PD
    NP_001263123.1
    NP_651821.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30729837..30731165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276194.1 → NP_001263123.1  uncharacterized protein Dmel_CG11313, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263123.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KI65, Q4V3K5
      Conserved Domains (3) summary
      smart00020
      Location:116 → 361
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:116 → 364
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam12032
      Location:24 → 78
      CLIP; Regulatory CLIP domain of proteinases

    2. NM_143564.3 → NP_651821.3  uncharacterized protein Dmel_CG11313, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651821.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V3K5, Q9VA44
      Conserved Domains (3) summary
      smart00020
      Location:116 → 364
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:116 → 367
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam12032
      Location:24 → 78
      CLIP; Regulatory CLIP domain of proteinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KI65 A0A0B4KI65
    Q9VA44 Q9VA44

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