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    ESR2 estrogen receptor 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 403639, updated on 19-Jun-2024

    Summary

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    Official Symbol
    ESR2provided by VGNC
    Official Full Name
    estrogen receptor 2provided by VGNC
    Primary source
    VGNC:VGNC:40477
    See related
    Ensembl:ENSCAFG00845001856
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    ERBETA
    Orthologs
    human mouse all
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    Genomic context

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    See ESR2 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 8 NC_051812.1 (38869013..38937387, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 8 NC_006590.4 (38338303..38407225, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 8 NC_049229.1 (38921461..38990144, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 8 NC_049268.1 (38489186..38557866, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 8 NC_049749.1 (38561325..38629870, complement)

    Chromosome 8 - NC_051812.1Genomic Context describing neighboring genes Neighboring gene spectrin repeat containing nuclear envelope protein 2 Neighboring gene 40S ribosomal protein S29-like Neighboring gene 28S ribosomal protein S36, mitochondrial-like Neighboring gene WW domain-binding protein 11-like Neighboring gene DNA mismatch repair protein Msh6-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of estrogen receptor alpha and beta genes in the mediobasal hypothalamus, pituitary and ovary during the canine estrous cycle. Hatoya S, et al. Neurosci Lett, 2003 Aug 21. PMID 12873744
    2. A cyclized peptide derived from alpha fetoprotein inhibits the proliferation of ER-positive canine mammary cancer cells. Torres CG, et al. Oncol Rep, 2009 Jun. PMID 19424616
    3. Sex steroid receptors and apoptosis-related proteins are differentially expressed in polycystic ovaries of adult dogs. Chuffa LG, et al. Tissue Cell, 2016 Feb. PMID 26767421
    4. Immunolocalization of androgen receptors, estrogen alpha receptors, and estrogen beta receptors in experimentally induced canine prostatic hyperplasia. Gallardo F, et al. J Androl, 2009 May-Jun. PMID 19136389

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We concluded that sex steroid receptors and apoptotic proteins are differentially expressed in the follicles of adult dogs with polystic ovaries
      Title: Sex steroid receptors and apoptosis-related proteins are differentially expressed in polycystic ovaries of adult dogs.
    2. AR, ER alpha, and ER beta are differently expressed in canine prostate tissue
      Title: Immunolocalization of androgen receptors, estrogen alpha receptors, and estrogen beta receptors in experimentally induced canine prostatic hyperplasia.
    3. A cyclized peptide derived from alpha fetoprotein inhibits the proliferation of ER-positive canine mammary cancer cells.
      Title: A cyclized peptide derived from alpha fetoprotein inhibits the proliferation of ER-positive canine mammary cancer cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables nuclear estrogen receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in estrogen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    estrogen receptor beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051812.1 Reference ROS_Cfam_1.0

      Range
      38869013..38937387 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038673834.1 → XP_038529762.1  estrogen receptor beta

      UniProtKB/TrEMBL
      A0A8C0K1X2, A0A8P0NH92
      Related
      ENSCAFP00845002631.1, ENSCAFT00845003321.1
      Conserved Domains (3) summary
      cd06949
      Location:282 → 517
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:163 → 244
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam12497
      Location:31 → 144
      ERbeta_N; Estrogen receptor beta

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049268.1 Alternate UMICH_Zoey_3.1

      Range
      38489186..38557866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038483454.1 → XP_038339382.1  estrogen receptor beta

      Conserved Domains (3) summary
      cd06949
      Location:282 → 517
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:163 → 244
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam12497
      Location:31 → 144
      ERbeta_N; Estrogen receptor beta

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049749.1 Alternate UNSW_CanFamBas_1.0

      Range
      38561325..38629870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038609030.1 → XP_038464958.1  estrogen receptor beta

      Conserved Domains (3) summary
      cd06949
      Location:282 → 517
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:163 → 244
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam12497
      Location:31 → 144
      ERbeta_N; Estrogen receptor beta

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049229.1 Alternate UU_Cfam_GSD_1.0

      Range
      38921461..38990144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038544913.1 → XP_038400841.1  estrogen receptor beta

      UniProtKB/TrEMBL
      A0A8C0K1X2, A0A8C0QK22, A0A8P0NH92
      Conserved Domains (3) summary
      cd06949
      Location:282 → 517
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:163 → 244
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam12497
      Location:31 → 144
      ERbeta_N; Estrogen receptor beta

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006590.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      38338303..38407225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038589140.1 → XP_038445068.1  estrogen receptor beta

      UniProtKB/TrEMBL
      A0A8C0K1X2, A0A8C0QK22, A0A8P0NH92
      Conserved Domains (3) summary
      cd06949
      Location:282 → 517
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:163 → 244
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam12497
      Location:31 → 144
      ERbeta_N; Estrogen receptor beta
    Nucleotide Protein
    Heading Accession and Version

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