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    Luzp1 leucine zipper protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79428, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Luzp1provided by RGD
    Official Full Name
    leucine zipper protein 1provided by RGD
    Primary source
    RGD:61839
    See related
    Ensembl:ENSRNOG00000022402 AllianceGenome:RGD:61839
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Luzp
    Summary
    Predicted to be involved in neural fold bending. Predicted to act upstream of or within artery development and ventricular septum development. Predicted to be located in nucleus. Orthologous to human LUZP1 (leucine zipper protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 107.0), Kidney (RPKM 99.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (153989570..154065071)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (148706094..148781616)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (154831697..154907646)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103181 Neighboring gene 5-hydroxytryptamine receptor 1D Neighboring gene aminoacyl tRNA synthase complex-interacting multifunctional protein 1-like Neighboring gene lysine demethylase 1A Neighboring gene uncharacterized LOC120103012 Neighboring gene testis expressed 46

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Restricted expression of LUZP in neural lineage cells: a study in embryonic stem cells. Lee MW, et al. J Biomed Sci, 2001 Nov-Dec. PMID 11702014
    2. LUZP deficiency affects neural tube closure during brain development. Hsu CY, et al. Biochem Biophys Res Commun, 2008 Nov 21. PMID 18801334
    3. Identification, molecular characterization, and chromosomal localization of the cDNA encoding a novel leucine zipper motif-containing protein. Sun DS, et al. Genomics, 1996 Aug 15. PMID 8812416
    4. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454
    5. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in artery development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within artery development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural fold bending IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neural fold bending IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neural fold bending ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ventricular septum development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ventricular septum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine zipper protein 1
    Names
    leucine zipper motif-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030830.2 → NP_110457.2  leucine zipper protein 1

      See identical proteins and their annotated locations for NP_110457.2

      Status: VALIDATED

      Source sequence(s)
      CH473968
      UniProtKB/Swiss-Prot
      Q9ESV1
      UniProtKB/TrEMBL
      A6ITB5, G3V7L9
      Related
      ENSRNOP00000016514.2, ENSRNOT00000016093.4
      Conserved Domains (1) summary
      COG1196
      Location:10 → 348
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      153989570..154065071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239274.5 → XP_006239336.1  leucine zipper protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006239336.1

      UniProtKB/Swiss-Prot
      Q9ESV1
      UniProtKB/TrEMBL
      A6ITB5, G3V7L9
      Conserved Domains (1) summary
      COG1196
      Location:10 → 348
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_063288465.1 → XP_063144535.1  leucine zipper protein 1 isoform X1

      UniProtKB/TrEMBL
      A6ITB5, G3V7L9

    3. XM_063288466.1 → XP_063144536.1  leucine zipper protein 1 isoform X1

      UniProtKB/TrEMBL
      A6ITB5, G3V7L9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ESV1.1 GenPept UniProtKB/Swiss-Prot:Q9ESV1

    Gene LinkOut

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