ppl periplakin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pplprovided by ZNC
Official Full Name: periplakinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041008-196
See related: Ensembl:ENSDARG00000101043 AllianceGenome:ZFIN:ZDB-GENE-041008-196
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb180; sb:cb180; im:7140067; im:7149519
Summary: Predicted to enable structural molecule activity. Predicted to be involved in intermediate filament cytoskeleton organization and wound healing. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and membrane. Predicted to colocalize with intermediate filament. Is expressed in several structures, including EVL; digestive system; fin; periderm; and sensory system. Orthologous to human PPL (periplakin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (36459789..36481993, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (36317932..36340138, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables structural molecule activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intermediate filament cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intermediate filament cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in wound healing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
colocalizes_with intermediate filament	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: periplakin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001137666.1 → NP_001131138.1 periplakin

Status: PROVISIONAL

Source sequence(s)

BX908771

UniProtKB/TrEMBL

A0A286YAI4, A0A8M1NJ02

Related

ENSDARP00000144181.2, ENSDART00000176547.2

Conserved Domains (4) summary

COG1196
Location:888 → 1646

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR04523
Location:585 → 1165

Mplasa_alph_rch; helix-rich Mycoplasma protein

pfam07407
Location:1528 → 1656

Seadorna_VP6; Seadornavirus VP6 protein

cl02488
Location:210 → 401

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

36459789..36481993 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005164103.4 → XP_005164160.1 periplakin isoform X1

UniProtKB/TrEMBL

A0A0R4IAS2, A0A8M2BBC1

Related

ENSDARP00000130075.1, ENSDART00000157729.2

Conserved Domains (4) summary

COG1196
Location:890 → 1648

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR04523
Location:587 → 1167

Mplasa_alph_rch; helix-rich Mycoplasma protein

pfam07407
Location:1530 → 1658

Seadorna_VP6; Seadornavirus VP6 protein

cl02488
Location:210 → 401

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...