Lgr3 Leucine-rich repeat-containing G protein-coupled receptor 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Lgr3provided by FlyBase
Official Full Name: Leucine-rich repeat-containing G protein-coupled receptor 3provided by FlyBase
Primary source: FLYBASE:FBgn0039354
Locus tag: Dmel_CG31096
See related: AllianceGenome:FB:FBgn0039354
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0170980.25; anon-WO0170980.26; CG31096; CG5042; CG5046; CT16193; dLGR3; DLGR3; Dmel\CG31096; lgr3; LGR3
Summary: Enables G protein-coupled receptor activity and insulin-like growth factor binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of developmental growth; and negative regulation of pupariation. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; epithelial tube; fat body; gut section; and reproductive system. Human ortholog(s) of this gene implicated in cryptorchidism. Orthologous to human RXFP1 (relaxin family peptide receptor 1) and RXFP2 (relaxin family peptide receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 96E8-96E9; 3-88 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (25665809..25677214)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (21491531..21502936)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ecdysone regulates the Drosophila imaginal disc epithelial barrier, determining the length of regeneration checkpoint delay.
Title: Ecdysone regulates the Drosophila imaginal disc epithelial barrier, determining the length of regeneration checkpoint delay.
The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction.
Title: The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction.
Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain.
Title: Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain.
Here we demonstrate that the Drosophila relaxin receptor homolog Lgr3, a leucine-rich repeat-containing G-protein-coupled receptor, is required for Dilp8-dependent growth coordination and developmental delay during the regeneration checkpoint; we demonstrate that Lgr3 activity in both the CNS and PG is necessary for NOS activation in the PG following damage
Title: Growth Coordination During Drosophila melanogaster Imaginal Disc Regeneration Is Mediated by Signaling Through the Relaxin Receptor Lgr3 in the Prothoracic Gland.
Leucine-rich repeat-containing G protein-coupled receptor 3 (Lgr3) mediates the checkpoint function of Dilp8 for entry into maturation. Two Lgr3-positive neurons in each brain lobe are required to induce a developmental delay upon overexpression of Dilp8.
Title: Drosophila Lgr3 Couples Organ Growth with Maturation and Ensures Developmental Stability.
Coordinated regulation of Lgr3 by Fru and Dsx marks a point of convergence of the two branches of the sex-determination hierarchy
Title: Sex-specific regulation of Lgr3 in Drosophila neurons.
Mutation of Lgr3 suppresses the delay in pupariation induced by imaginal disc growth perturbation or ectopic Dilp8 expression.
Title: Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing.
dLGR3 is expressed in the female fat body, while the expression of dLGR4 peaks in the midgut of both the wandering and adult stage.
Title: Cloning, constitutive activity and expression profiling of two receptors related to relaxin receptors in Drosophila melanogaster.
this study shows Lgr3 is a Dilp8 receptor
Title: A brain circuit that synchronizes growth and maturation revealed through Dilp8 binding to Lgr3.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Dm2246 (e-PCR)
- UniSTS:58756

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables neuropeptide receptor activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISM Inferred from Sequence Model more info	PubMed
involved_in activation of adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of pupariation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of developmental growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: Leucine-rich repeat-containing G protein-coupled receptor 3

Names: CG31096-PA; Lgr3-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

25665809..25677214

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170236.2 → NP_733115.1 Leucine-rich repeat-containing G protein-coupled receptor 3 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733115.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86P34, Q9VBP0

Related

FBpp0084273

Conserved Domains (5) summary

cd00112
Location:32 → 65

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00116
Location:196 → 354

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:181 → 204

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:447 → 704

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13855
Location:179 → 239

LRR_8; Leucine rich repeat