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    Vav3 vav guanine nucleotide exchange factor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295378, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Vav3provided by RGD
    Official Full Name
    vav guanine nucleotide exchange factor 3provided by RGD
    Primary source
    RGD:1565941
    See related
    Ensembl:ENSRNOG00000020485 AllianceGenome:RGD:1565941
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565941
    Summary
    Predicted to enable epidermal growth factor receptor binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including B cell receptor signaling pathway; positive regulation of B cell proliferation; and regulation of cell size. Predicted to act upstream of or within several processes, including integrin-mediated signaling pathway; neutrophil chemotaxis; and positive regulation of phosphatidylinositol 3-kinase activity. Predicted to be located in cytoplasm and immunological synapse. Orthologous to human VAV3 (vav guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 137.3), Kidney (RPKM 129.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vav3 in Genome Data Viewer
    Location:
    2q41
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (199699861..200042344)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (197011901..197354321)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (212247061..212585818)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25, member 54 Neighboring gene solute carrier family 25 member 24 Neighboring gene uncharacterized LOC120100608 Neighboring gene uncharacterized LOC120100920 Neighboring gene mitochondrial ribosomal protein S17, pseudogene 1 Neighboring gene uncharacterized LOC120100919 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene netrin G1 Neighboring gene uncharacterized LOC120100921

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Rho protein exchange factor Vav3 regulates vascular smooth muscle cell proliferation and migration. Toumaniantz G, et al. Cardiovasc Res, 2010 Apr 1. PMID 19969623
    2. Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76. Charvet C, et al. J Biol Chem, 2005 Apr 15. PMID 15708849
    3. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Crespo P, et al. Nature, 1997 Jan 9. PMID 8990121
    4. P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses. Lawson CD, et al. J Immunol, 2011 Feb 1. PMID 21178006
    5. ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. Joshi AD, et al. Clin Cancer Res, 2007 Sep 15. PMID 17875758

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of Vav3 expression for inflammation and cell death during experimental myocardial infarction.
      Title: The role of Vav3 expression for inflammation and cell death during experimental myocardial infarction.
    2. The Rho GEF Vav3 controls vascular smooth muscle cell proliferation and migration through activation of Rac1/PAK signalling
      Title: The Rho protein exchange factor Vav3 regulates vascular smooth muscle cell proliferation and migration.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell projection assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within small GTPase-mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in immunological synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide exchange factor VAV3
    Names
    vav 3 guanine nucleotide exchange factor
    vav 3 oncogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191714.1 → NP_001178643.1  guanine nucleotide exchange factor VAV3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5ZPB5, A0A8I6A8C8
      Related
      ENSRNOP00000080097.1, ENSRNOT00000098387.1
      Conserved Domains (8) summary
      cd10407
      Location:666 → 768
      SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
      cd11978
      Location:791 → 846
      SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
      cd11981
      Location:596 → 657
      SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
      cd00029
      Location:514 → 561
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:193 → 369
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:383 → 506
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00169
      Location:407 → 502
      PH; PH domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      199699861..200042344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017590775.3 → XP_017446264.1  guanine nucleotide exchange factor VAV3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8C8
      Related
      ENSRNOP00000027813.6

    2. XM_063281659.1 → XP_063137729.1  guanine nucleotide exchange factor VAV3 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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