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    CEACAM5 CEA cell adhesion molecule 5 [ Homo sapiens (human) ]

    Gene ID: 1048, updated on 7-Apr-2024

    Summary

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    Official Symbol
    CEACAM5provided by HGNC
    Official Full Name
    CEA cell adhesion molecule 5provided by HGNC
    Primary source
    HGNC:HGNC:1817
    See related
    Ensembl:ENSG00000105388 MIM:114890; AllianceGenome:HGNC:1817
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CEA; CD66e
    Summary
    This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
    Expression
    Biased expression in colon (RPKM 540.8), appendix (RPKM 102.3) and 2 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    19q13.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41708626..41730433)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44527954..44549792)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42212545..42234353)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372405 Neighboring gene CEA cell adhesion molecule 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10670 Neighboring gene uncharacterized LOC112268252 Neighboring gene CEA cell adhesion molecule 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42282657-42283158 Neighboring gene CEA cell adhesion molecule 1 pseudogene Neighboring gene CEA cell adhesion molecule 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of CEACAM5 as a stemness-related inhibitory immune checkpoint in pancreatic cancer. Shi H, et al. BMC Cancer, 2022 Dec 9. PMID 36494785, Free PMC Article
    2. CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial-mesenchymal transition via inhibiting MDM2. Wang X, et al. Clin Sci (Lond), 2022 Nov 30. PMID 36377775, Free PMC Article
    3. Serum carcinoembryonic antigen and carbohydrate antigen 19-9 as preoperative diagnostic biomarkers of extrahepatic bile duct cancer. Kim HS, et al. BJS Open, 2021 Nov 9. PMID 34935900, Free PMC Article
    4. Effect of triptolide and chemotherapy on carcinoembryonic and carbohydrate antigens levels and first-line treatment of recurrent nasopharyngeal carcinoma. Liu C, et al. Cell Mol Biol (Noisy-le-grand), 2021 Aug 31. PMID 34817331
    5. A highly-specific fully-human antibody and CAR-T cells targeting CD66e/CEACAM5 are cytotoxic for CD66e-expressing cancer cells in vitro and in vivo. Baek DS, et al. Cancer Lett, 2022 Jan 28. PMID 34740610

    See all (290) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phenotypic screen of sixty-eight colorectal cancer cell lines identifies CEACAM6 and CEACAM5 as markers of acid resistance.
      Title: Phenotypic screen of sixty-eight colorectal cancer cell lines identifies CEACAM6 and CEACAM5 as markers of acid resistance.
    2. Detection and clinical significance of CEACAM5 methylation in colorectal cancer patients.
      Title: Detection and clinical significance of CEACAM5 methylation in colorectal cancer patients.
    3. Differential expression of carcinoembryonic antigen-related cell adhesion molecule-5 (CEACAM5) and dipeptidyl peptidase-4 (DPP4) with detection of Middle East respiratory syndrome-coronavirus in peripheral blood.
      Title: Differential expression of carcinoembryonic antigen-related cell adhesion molecule-5 (CEACAM5) and dipeptidyl peptidase-4 (DPP4) with detection of Middle East respiratory syndrome-coronavirus in peripheral blood.
    4. [Heterogeneity analysis of pancreatic cancer and identification of molecular subtypes of tumor cells based on CEACAM5, LGALS1 and CENPF gene expression].
      Title: [Heterogeneity analysis of pancreatic cancer and identification of molecular subtypes of tumor cells based on CEACAM5, LGALS1 and CENPF gene expression].
    5. Combination of CEACAM5, EpCAM and CK19 gene expressions in mediastinal lymph node micrometastasis is a prognostic factor for non-small cell lung cancer.
      Title: Combination of CEACAM5, EpCAM and CK19 gene expressions in mediastinal lymph node micrometastasis is a prognostic factor for non-small cell lung cancer.
    6. Identification of CEACAM5 as a stemness-related inhibitory immune checkpoint in pancreatic cancer.
      Title: Identification of CEACAM5 as a stemness-related inhibitory immune checkpoint in pancreatic cancer.
    7. CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial-mesenchymal transition via inhibiting MDM2.
      Title: CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial-mesenchymal transition via inhibiting MDM2.
    8. Trajectories of Perioperative Serum Tumor Markers and Colorectal Cancer Outcomes: A Retrospective, Multicenter Longitudinal Cohort Study.
      Title: Trajectories of Perioperative Serum Tumor Markers and Colorectal Cancer Outcomes: A Retrospective, Multicenter Longitudinal Cohort Study.
    9. Serum carcinoembryonic antigen and carbohydrate antigen 19-9 as preoperative diagnostic biomarkers of extrahepatic bile duct cancer.
      Title: Serum carcinoembryonic antigen and carbohydrate antigen 19-9 as preoperative diagnostic biomarkers of extrahepatic bile duct cancer.
    10. Effect of triptolide and chemotherapy on carcinoembryonic and carbohydrate antigens levels and first-line treatment of recurrent nasopharyngeal carcinoma.
      Title: Effect of triptolide and chemotherapy on carcinoembryonic and carbohydrate antigens levels and first-line treatment of recurrent nasopharyngeal carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (245)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp781M2392

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GPI anchor binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homotypic cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of anoikis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of myotube differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carcinoembryonic antigen-related cell adhesion molecule 5
    Names
    carcinoembryonic antigen related cell adhesion molecule 5
    meconium antigen 100

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291484.3 → NP_001278413.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_001278413.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR compared to variant 1. Both variants 1 and 2 encode isoform 1.
      Source sequence(s)
      AC243967, AK223101, DB006625, M29540
      Consensus CDS
      CCDS12584.1
      UniProtKB/Swiss-Prot
      H9KVA7, P06731
      UniProtKB/TrEMBL
      A0A024R0K5, Q53G30, Q8N4D0
      Related
      ENSP00000385072.1, ENST00000405816.5
      Conserved Domains (5) summary
      cd05740
      Location:324 → 412
      Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:244 → 318
      IG_like; Immunoglobulin like
      pfam13895
      Location:240 → 318
      Ig_2; Immunoglobulin domain
      cl11960
      Location:502 → 590
      Ig; Immunoglobulin domain

    2. NM_001308398.2 → NP_001295327.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform 2 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site at an internal exon and differs in the 3' UTR compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK223101, DB006625, X16455
      Consensus CDS
      CCDS77302.1
      UniProtKB/TrEMBL
      Q53G30, Q8N4D0
      Conserved Domains (5) summary
      cd05740
      Location:323 → 411
      Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:244 → 318
      IG_like; Immunoglobulin like
      pfam13895
      Location:240 → 318
      Ig_2; Immunoglobulin domain
      cl11960
      Location:501 → 589
      Ig; Immunoglobulin domain

    3. NM_004363.6 → NP_004354.3  carcinoembryonic antigen-related cell adhesion molecule 5 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_004354.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC243967, DB006625, M15042
      Consensus CDS
      CCDS12584.1
      UniProtKB/Swiss-Prot
      H9KVA7, P06731
      UniProtKB/TrEMBL
      A0A024R0K5, Q53G30, Q8N4D0
      Related
      ENSP00000221992.5, ENST00000221992.11
      Conserved Domains (5) summary
      cd05740
      Location:324 → 412
      Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:244 → 318
      IG_like; Immunoglobulin like
      pfam13895
      Location:240 → 318
      Ig_2; Immunoglobulin domain
      cl11960
      Location:502 → 590
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      41708626..41730433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026145.3 → XP_016881634.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform X1

      UniProtKB/TrEMBL
      Q53G30, Q8N4D0
      Related
      ENSP00000381600.4, ENST00000398599.8
      Conserved Domains (5) summary
      cd05740
      Location:323 → 411
      Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:244 → 318
      IG_like; Immunoglobulin like
      pfam13895
      Location:240 → 318
      Ig_2; Immunoglobulin domain
      cl11960
      Location:501 → 589
      Ig; Immunoglobulin domain

    2. XM_017026146.3 → XP_016881635.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform X2

      UniProtKB/TrEMBL
      Q53G30, Q8N4D0
      Related
      ENSP00000482157.1, ENST00000615021.4

    3. XM_011526322.3 → XP_011524624.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform X3

      UniProtKB/TrEMBL
      A0A087WYX0, T2HVB7
      Conserved Domains (5) summary
      cd05740
      Location:146 → 234
      Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:244 → 318
      IG_like; Immunoglobulin like
      pfam13895
      Location:240 → 318
      Ig_2; Immunoglobulin domain
      cl11960
      Location:324 → 412
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      44527954..44549792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319536.1 → XP_054175511.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform X1

    2. XM_054319537.1 → XP_054175512.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform X2

    3. XM_054319538.1 → XP_054175513.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06731.4 GenPept UniProtKB/Swiss-Prot:P06731

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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