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    can cannonball [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45432, updated on 10-May-2024

    Summary

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    Official Symbol
    canprovided by FlyBase
    Official Full Name
    cannonballprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011569
    Locus tag
    Dmel_CG6577
    See related
    AllianceGenome:FB:FBgn0011569
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Can; CG6577; Dmel\CG6577; dmTAF5b; dTAF5L; dTAF[[II]]80; TAF5; taf5L; Taf5L; TAF5L; WSB-1; WSB1
    Summary
    Involved in male meiosis I; regulation of gene expression; and spermatid development. Located in male germ cell nucleus and nucleolus. Is expressed in spermatozoon. Orthologous to human TAF5 (TATA-box binding protein associated factor 5). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See can in Genome Data Viewer
    Location:
    67D12-67D12; 3-32 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10263909..10267111, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10257009..10260211, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44539 Neighboring gene long non-coding RNA:CR44540 Neighboring gene long non-coding RNA:CR45242 Neighboring gene Odorant receptor 67d

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcription factor IID--not so basal after all. Verrijzer CP. Science, 2001 Sep 14. PMID 11557865
    2. Differential expression of the Drosophila mitofusin genes fuzzy onions (fzo) and dmfn. Hwa JJ, et al. Mech Dev, 2002 Aug. PMID 12128227
    3. The piRNA pathway is developmentally regulated during spermatogenesis in Drosophila. Quénerch'du E, et al. RNA, 2016 Jul. PMID 27208314, Free PMC Article
    4. Genome-wide analysis of SU(VAR)3-9 distribution in chromosomes of Drosophila melanogaster. Maksimov DA, et al. Chromosoma, 2018 Mar. PMID 28975408
    5. Drosophila dany is essential for transcriptional control and nuclear architecture in spermatocytes. Trost M, et al. Development, 2016 Jul 15. PMID 27436041

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dj encodes proteins of the spermatid nucleus and the flagellum and is regulated at the transcriptional level by can.
      Title: In Drosophila, don juan and don juan like encode proteins of the spermatid nucleus and the flagellum and both are regulated at the transcriptional level by the TAF II80 cannonball while translational repression is achieved by distinct elements.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in spermatid differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIID complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cannonball
    Names
    CG6577-PA
    can-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      10263909..10267111 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080088.2 → NP_524827.1  cannonball [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524827.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VT91
      Related
      FBpp0076028
      Conserved Domains (4) summary
      cd08044
      Location:320 → 453
      TAF5_NTD2; TAF5_NTD2 is the second conserved N-terminal region of TATA Binding Protein (TBP) Associated Factor 5 (TAF5), involved in forming Transcription Factor IID (TFIID)
      COG2319
      Location:503 → 829
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:619 → 823
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:629 → 666
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VT91 Q9VT91

    Gene LinkOut

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