Cttnbp2 cortactin binding protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cttnbp2provided by RGD
Official Full Name: cortactin binding protein 2provided by RGD
Primary source: RGD:628691
See related: Ensembl:ENSRNOG00000061845 AllianceGenome:RGD:628691
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cbp90; Cortbp2
Summary: Enables SH3 domain binding activity. Involved in brain development and regulation of modification of postsynaptic actin cytoskeleton. Located in synaptic vesicle. Is active in glutamatergic synapse. Orthologous to human CTTNBP2 (cortactin binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 168.9), Adrenal (RPKM 67.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q22

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (47766867..47930598, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (46800975..46964681, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (42932897..43096454, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Autism-linked mutations of CTTNBP2 reduce social interaction and impair dendritic spine formation via diverse mechanisms.
Title: Autism-linked mutations of CTTNBP2 reduce social interaction and impair dendritic spine formation via diverse mechanisms.
Cttnbp2 increases microtubule stability and regulates dendritic arborization.
Title: Cortactin-binding protein 2 increases microtubule stability and regulates dendritic arborization.
This sst=udy demonistrated that Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance.
Title: Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF413676 (e-PCR)
- UniSTS:248584

RH144522 (e-PCR)
- UniSTS:233767

AI045527 (e-PCR)
- UniSTS:248399

REN62251 (e-PCR)
- UniSTS:387051

REN62252 (e-PCR)
- UniSTS:387052

BF401529 (e-PCR)
- UniSTS:245492

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of modification of postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cortactin-binding protein 2

Names: brain specific cortactin-binding protein CBP90

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114401.1 → NP_001107873.1 cortactin-binding protein 2

See identical proteins and their annotated locations for NP_001107873.1

Status: PROVISIONAL

Source sequence(s)

DP000027

UniProtKB/Swiss-Prot

O88864, Q2IBD4

UniProtKB/TrEMBL

A0A8I5YC08

Related

ENSRNOP00000072761.1, ENSRNOT00000087167.2

Conserved Domains (8) summary

PRK11331
Location:1077 → 1357

PRK11331; 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional

cd00204
Location:728 → 853

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam09486
Location:108 → 258

HrpB7; Bacterial type III secretion protein (HrpB7)

pfam09727
Location:36 → 179

CortBP2; Cortactin-binding protein-2

pfam12796
Location:738 → 829

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:702 → 754

Ank_4; Ankyrin repeats (many copies)

pfam13863
Location:135 → 228

DUF4200; Domain of unknown function (DUF4200)

sd00045
Location:766 → 797

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

47766867..47930598 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107159.2 → XP_038963087.1 cortactin-binding protein 2 isoform X2

UniProtKB/TrEMBL

A0A8I5YC08

Related

ENSRNOP00000077746.1

Conserved Domains (6) summary

PRK11331
Location:1036 → 1318

PRK11331; 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional

PHA03247
Location:317 → 669

PHA03247; large tegument protein UL36; Provisional

sd00045
Location:725 → 756

ANK; ANK repeat [structural motif]

pfam15921
Location:134 → 476

CCDC158; Coiled-coil domain-containing protein 158

pfam09727
Location:36 → 179

CortBP2; Cortactin-binding protein-2

pfam12796
Location:697 → 791

Ank_2; Ankyrin repeats (3 copies)
XM_017592494.3 → XP_017447983.1 cortactin-binding protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I5YC08
XM_039107160.2 → XP_038963088.1 cortactin-binding protein 2 isoform X3

Conserved Domains (6) summary

PRK11331
Location:1077 → 1267

PRK11331; 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional

PHA03247
Location:272 → 703

PHA03247; large tegument protein UL36; Provisional

sd00045
Location:766 → 797

ANK; ANK repeat [structural motif]

pfam15921
Location:134 → 476

CCDC158; Coiled-coil domain-containing protein 158

pfam09727
Location:36 → 179

CortBP2; Cortactin-binding protein-2

pfam12796
Location:738 → 832

Ank_2; Ankyrin repeats (3 copies)
XM_039107161.2 → XP_038963089.1 cortactin-binding protein 2 isoform X4

Conserved Domains (6) summary

PHA02874
Location:702 → 909

PHA02874; ankyrin repeat protein; Provisional

PHA03247
Location:276 → 703

PHA03247; large tegument protein UL36; Provisional

sd00045
Location:766 → 797

ANK; ANK repeat [structural motif]

pfam15921
Location:134 → 476

CCDC158; Coiled-coil domain-containing protein 158

pfam09727
Location:36 → 179

CortBP2; Cortactin-binding protein-2

pfam12796
Location:738 → 832

Ank_2; Ankyrin repeats (3 copies)
XM_039107162.2 → XP_038963090.1 cortactin-binding protein 2 isoform X5

Conserved Domains (5) summary

PHA03247
Location:276 → 703

PHA03247; large tegument protein UL36; Provisional

sd00045
Location:702 → 731

ANK; ANK repeat [structural motif]

pfam15921
Location:134 → 476

CCDC158; Coiled-coil domain-containing protein 158

pfam09727
Location:36 → 179

CortBP2; Cortactin-binding protein-2

pfam12796
Location:704 → 781

Ank_2; Ankyrin repeats (3 copies)