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    Lcp1 lymphocyte cytosolic protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306071, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Lcp1provided by RGD
    Official Full Name
    lymphocyte cytosolic protein 1provided by RGD
    Primary source
    RGD:1308288
    See related
    Ensembl:ENSRNOG00000010319 AllianceGenome:RGD:1308288
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including GTPase binding activity; actin filament binding activity; and integrin binding activity. Involved in animal organ regeneration. Predicted to be located in several cellular components, including focal adhesion; podosome; and ruffle. Predicted to be active in actin filament; actin filament bundle; and cytoplasm. Predicted to colocalize with perinuclear region of cytoplasm and stress fiber. Orthologous to human LCP1 (lymphocyte cytosolic protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 1086.5), Thymus (RPKM 762.0) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lcp1 in Genome Data Viewer
    Location:
    15q11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (56846375..56954090)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (50443300..50544682)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (57170566..57277811)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeats and calponin homology domain containing 1 Neighboring gene uncharacterized LOC134482151 Neighboring gene uncharacterized LOC108352942 Neighboring gene rubicon like autophagy enhancer Neighboring gene uncharacterized LOC120097039 Neighboring gene leucine rich repeat containing 63 Neighboring gene establishment of cohesion 1 homolog 2 (S. cerevisiae), pseudogene 2 Neighboring gene tRNA methyltransferase 10A, pseudogene 1 Neighboring gene U6 spliceosomal RNA Neighboring gene carboxypeptidase B2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. LCP1 up-regulated by partial pancreatectomy supports cell proliferation and differentiation. Choi JH, et al. Mol Biosyst, 2011 Nov. PMID 21922118
    2. Costimulation induced phosphorylation of L-plastin facilitates surface transport of the T cell activation molecules CD69 and CD25. Wabnitz GH, et al. Eur J Immunol, 2007 Mar. PMID 17294403
    3. Phosphorylation on Ser5 increases the F-actin-binding activity of L-plastin and promotes its targeting to sites of actin assembly in cells. Janji B, et al. J Cell Sci, 2006 May 1. PMID 16636079
    4. Proteomic analysis of differential protein expression in early process of pancreatic regeneration in pancreatectomized rats. Yang M, et al. Acta Pharmacol Sin, 2006 May. PMID 16626512
    5. Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells. Zu Y, et al. Biochemistry, 1990 Jan 30. PMID 2111166

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of the Glycolysis Prevents the Cerebral Infarction Progression Through Decreasing the Lactylation Levels of LCP1.
      Title: Inhibition of the Glycolysis Prevents the Cerebral Infarction Progression Through Decreasing the Lactylation Levels of LCP1.
    2. the LCP1 may play a critical role in the pancreas regeneration.
      Title: LCP1 up-regulated by partial pancreatectomy supports cell proliferation and differentiation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament network formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in animal organ regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of podosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein kinase A signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in wound healing, spreading of cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in actin filament bundle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin filament bundle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in glial cell projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic cup ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in podosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    plastin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012044.1 → NP_001012044.1  plastin-2

      See identical proteins and their annotated locations for NP_001012044.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083855
      UniProtKB/TrEMBL
      A0A8I6AGS0, Q5XI38
      Related
      ENSRNOP00000014502.3, ENSRNOT00000014502.6
      Conserved Domains (5) summary
      smart00033
      Location:398 → 501
      CH; Calponin homology domain
      COG5069
      Location:16 → 620
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00014
      Location:121 → 236
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00051
      Location:13 → 79
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00307
      Location:265 → 370
      CH; Calponin homology (CH) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      56846375..56954090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274316.1 → XP_063130386.1  plastin-2 isoform X1

      UniProtKB/TrEMBL
      Q5XI38

    2. XM_006252319.3 → XP_006252381.1  plastin-2 isoform X1

      See identical proteins and their annotated locations for XP_006252381.1

      UniProtKB/TrEMBL
      A0A8I6AGS0, Q5XI38
      Conserved Domains (5) summary
      smart00033
      Location:398 → 501
      CH; Calponin homology domain
      COG5069
      Location:16 → 620
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00014
      Location:121 → 236
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00051
      Location:13 → 79
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00307
      Location:265 → 370
      CH; Calponin homology (CH) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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