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    TRMT112 tRNA methyltransferase activator subunit 11-2 [ Homo sapiens (human) ]

    Gene ID: 51504, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TRMT112provided by HGNC
    Official Full Name
    tRNA methyltransferase activator subunit 11-2provided by HGNC
    Primary source
    HGNC:HGNC:26940
    See related
    Ensembl:ENSG00000173113 MIM:618630; AllianceGenome:HGNC:26940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRM112; HSPC152; HSPC170; hTrm112; TRMT11-2
    Summary
    Enables protein heterodimerization activity and protein methyltransferase activity. Involved in macromolecule methylation and positive regulation of rRNA processing. Located in nucleoplasm and perinuclear region of cytoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal (RPKM 47.8), ovary (RPKM 46.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    11q13.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64316460..64318596, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64306441..64308577, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64083932..64086068, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene KCNK4-CATSPERZ readthrough (NMD candidate) Neighboring gene potassium two pore domain channel subfamily K member 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64066730-64067724 Neighboring gene catsper channel auxiliary subunit zeta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4897 Neighboring gene estrogen related receptor alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64083535-64084050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4898 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3477 Neighboring gene peroxiredoxin 5 Neighboring gene uncharacterized LOC102723878 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:64092812-64092964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64098506-64099028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4899 Neighboring gene CRISPRi-validated cis-regulatory element chr11.3041 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3479 Neighboring gene coiled-coil domain containing 88B Neighboring gene microRNA 7155

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. WBSCR22 and TRMT112 synergistically suppress cell proliferation, invasion and tumorigenesis in pancreatic cancer via transcriptional regulation of ISG15. Khan AA, et al. Int J Oncol, 2022 Mar. PMID 35088887, Free PMC Article
    2. THUMPD3-TRMT112 is a m2G methyltransferase working on a broad range of tRNA substrates. Yang WQ, et al. Nucleic Acids Res, 2021 Nov 18. PMID 34669960, Free PMC Article
    3. Structural insight into HEMK2-TRMT112-mediated glutamine methylation. Gao J, et al. Biochem J, 2020 Oct 16. PMID 32969463
    4. Structural insight into human N6amt1-Trm112 complex functioning as a protein methyltransferase. Li W, et al. Cell Discov, 2019. PMID 31636962, Free PMC Article
    5. Human HemK2/KMT9/N6AMT1 is an active protein methyltransferase, but does not act on DNA in vitro, in the presence of Trm112. Woodcock CB, et al. Cell Discov, 2019. PMID 31632689, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WBSCR22 and TRMT112 synergistically suppress cell proliferation, invasion and tumorigenesis in pancreatic cancer via transcriptional regulation of ISG15.
      Title: WBSCR22 and TRMT112 synergistically suppress cell proliferation, invasion and tumorigenesis in pancreatic cancer via transcriptional regulation of ISG15.
    2. Human TRMT112-Methyltransferase Network Consists of Seven Partners Interacting with a Common Co-Factor.
      Title: Human TRMT112-Methyltransferase Network Consists of Seven Partners Interacting with a Common Co-Factor.
    3. THUMPD3-TRMT112 is a m2G methyltransferase working on a broad range of tRNA substrates.
      Title: THUMPD3-TRMT112 is a m2G methyltransferase working on a broad range of tRNA substrates.
    4. Structural insight into HEMK2-TRMT112-mediated glutamine methylation.
      Title: Structural insight into HEMK2-TRMT112-mediated glutamine methylation.
    5. The down-regulation of TRMT112 does not affect the N6AMT1 protein levels in cells, suggesting that the two proteins of TRMT112 network, WBSCR22 and N6AMT1, are differently regulated by their common cofactor.
      Title: The Common Partner of Several Methyltransferases TRMT112 Regulates the Expression of N6AMT1 Isoforms in Mammalian Cells.
    6. METTL5-TRMT112 partners act by extruding the adenosine to be modified from a double-stranded nucleic acid.
      Title: The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112.
    7. The localization of the TRMT112 protein is determined by WBSCR22, and the WBSCR22-TRMT112 complex is localized in the cell nucleus.
      Title: The Stability of Ribosome Biogenesis Factor WBSCR22 Is Regulated by Interaction with TRMT112 via Ubiquitin-Proteasome Pathway.
    8. DIMT1L and WBSCR22-TRMT112 are required for distinct pre-rRNA processing reactions leading to synthesis of 18S rRNA. Ribosome biogenesis requires the presence of the modification enzyme rather than its RNA-modifying catalytic activity.
      Title: The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Expression of HIV-1 Tat upregulates the abundance of tRNA methyltransferase 11-2 homolog (TRMT112) in the nucleoli of Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA methyltransferase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-glutamine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-glutamine methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA (guanine-N7)-methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA (guanine-N7)-methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription initiation-coupled chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    multifunctional methyltransferase subunit TRM112-like protein
    Names
    TRM112-like protein
    tRNA methyltransferase 11-2 homolog
    tRNA methyltransferase 112 homolog
    tRNA methyltransferase subunit 11-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286082.2 → NP_001273011.1  multifunctional methyltransferase subunit TRM112-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AP001453, KF455402
      Consensus CDS
      CCDS66113.1
      UniProtKB/Swiss-Prot
      Q9UI30
      Related
      ENSP00000309433.2, ENST00000308774.6
      Conserved Domains (1) summary
      pfam03966
      Location:81 → 107
      Trm112p; Trm112p-like protein

    2. NM_001286084.2 → NP_001273013.1  multifunctional methyltransferase subunit TRM112-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AP001453, KF455402
      UniProtKB/TrEMBL
      F5GX77

    3. NM_001372071.1 → NP_001359000.1  multifunctional methyltransferase subunit TRM112-like protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AP001453, KF455402
      Consensus CDS
      CCDS8068.1
      UniProtKB/Swiss-Prot
      B2R539, J3KNG5, Q3MHC7, Q8N2Z4, Q9UI30
      Conserved Domains (1) summary
      cd21089
      Location:2 → 118
      Trm112-like; eukaryotic tRNA methyltransferase 112, a partner protein of both rRNA/tRNA and protein methyltransferases, and similar proteins

    4. NM_001372072.1 → NP_001359001.1  multifunctional methyltransferase subunit TRM112-like protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AP001453, KF455402
      Consensus CDS
      CCDS8068.1
      UniProtKB/Swiss-Prot
      B2R539, J3KNG5, Q3MHC7, Q8N2Z4, Q9UI30
      Conserved Domains (1) summary
      cd21089
      Location:2 → 118
      Trm112-like; eukaryotic tRNA methyltransferase 112, a partner protein of both rRNA/tRNA and protein methyltransferases, and similar proteins

    5. NM_016404.3 → NP_057488.1  multifunctional methyltransferase subunit TRM112-like protein isoform 1

      See identical proteins and their annotated locations for NP_057488.1

      Status: VALIDATED

      Source sequence(s)
      AP001453, KF455402
      Consensus CDS
      CCDS8068.1
      UniProtKB/Swiss-Prot
      B2R539, J3KNG5, Q3MHC7, Q8N2Z4, Q9UI30
      Related
      ENSP00000438349.2, ENST00000544844.6
      Conserved Domains (1) summary
      cd21089
      Location:2 → 118
      Trm112-like; eukaryotic tRNA methyltransferase 112, a partner protein of both rRNA/tRNA and protein methyltransferases, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      64316460..64318596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427119.1 → XP_047283075.1  multifunctional methyltransferase subunit TRM112-like protein isoform X1

      UniProtKB/Swiss-Prot
      B2R539, J3KNG5, Q3MHC7, Q8N2Z4, Q9UI30

    2. XM_047427118.1 → XP_047283074.1  multifunctional methyltransferase subunit TRM112-like protein isoform X1

      UniProtKB/Swiss-Prot
      B2R539, J3KNG5, Q3MHC7, Q8N2Z4, Q9UI30

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      64306441..64308577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369114.1 → XP_054225089.1  multifunctional methyltransferase subunit TRM112-like protein isoform X1

      UniProtKB/Swiss-Prot
      B2R539, J3KNG5, Q3MHC7, Q8N2Z4, Q9UI30

    2. XM_054369113.1 → XP_054225088.1  multifunctional methyltransferase subunit TRM112-like protein isoform X1

      UniProtKB/Swiss-Prot
      B2R539, J3KNG5, Q3MHC7, Q8N2Z4, Q9UI30
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UI30.1 GenPept UniProtKB/Swiss-Prot:Q9UI30

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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