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    DPYSL4 dihydropyrimidinase like 4 [ Homo sapiens (human) ]

    Gene ID: 10570, updated on 7-Apr-2024

    Summary

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    Official Symbol
    DPYSL4provided by HGNC
    Official Full Name
    dihydropyrimidinase like 4provided by HGNC
    Primary source
    HGNC:HGNC:3016
    See related
    Ensembl:ENSG00000151640 MIM:608407; AllianceGenome:HGNC:3016
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRMP3; DRP-4; ULIP4
    Summary
    Enables filamin binding activity. Predicted to be involved in nervous system development. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in brain (RPKM 6.6), heart (RPKM 2.6) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    10q26.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (132186948..132205759)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (133128313..133148570)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (134000452..134019263)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902525 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133809534-133810520 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133820384-133820908 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:133823019-133823543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133832958-133833629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133842692-133843192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133852590-133853427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133857569-133858086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133858087-133858604 Neighboring gene Janus kinase and microtubule interacting protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133878227-133878974 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:133881249-133881749 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11218 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11222 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11225 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11227 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133920928-133921428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133933330-133934168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133934169-133935006 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133951279-133951800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133955152-133955999 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133956000-133956846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133959409-133959910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133959911-133960410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133960832-133961794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133977007-133977706 Neighboring gene JAKMIP3 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134001171-134001672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4222 Neighboring gene serine/threonine kinase 32C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134056390-134057274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134067757-134068258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134068259-134068758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134078043-134078543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134096746-134097345 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:134111356-134111519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2953 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134122180-134122724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134122725-134123267 Neighboring gene Sharpr-MPRA regulatory region 5064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4223 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:134144980-134145514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4224 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:134152941-134153095 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134166187-134167149 Neighboring gene leucine rich repeat containing 27 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134203032-134203711 Neighboring gene uncharacterized LOC124902526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134208622-134209145 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134209146-134209668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2958

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes. Honnorat J, et al. Eur J Neurosci, 1999 Dec. PMID 10594648
    2. p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adipocytes and cancer cells. Nagano H, et al. Proc Natl Acad Sci U S A, 2018 Aug 14. PMID 30061407, Free PMC Article
    3. Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain. Weitzdoerfer R, et al. J Neural Transm Suppl, 2001. PMID 11771764
    4. Identification of Metabolic Syndrome-Related miRNA-mRNA Regulatory Networks and Key Genes Based on Bioinformatics Analysis. Qiu L, et al. Biochem Genet, 2023 Feb. PMID 35877019
    5. Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to DNA damage. Kimura J, et al. Int J Cancer, 2011 Apr 1. PMID 20499313

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of Metabolic Syndrome-Related miRNA-mRNA Regulatory Networks and Key Genes Based on Bioinformatics Analysis.
      Title: Identification of Metabolic Syndrome-Related miRNA-mRNA Regulatory Networks and Key Genes Based on Bioinformatics Analysis.
    2. DPYSL4 plays a key role in the tumor-suppressor function of p53 by regulating oxidative phosphorylation and the cellular energy supply via its association with mitochondrial supercomplexes, possibly linking to the pathophysiology of both cancer and obesity.
      Title: p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adipocytes and cancer cells.
    3. DPYSL4 is a novel apoptosis-inducible factor controlled by p53 in response to DNA damage
      Title: Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to DNA damage.
    4. Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain.
      Title: Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables dihydropyrimidinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables filamin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    NOT involved_in pyrimidine nucleobase catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    dihydropyrimidinase-related protein 4
    Names
    CRMP-3
    ULIP-4
    UNC33-like phosphoprotein 4
    collapsin response mediator protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006426.3 → NP_006417.2  dihydropyrimidinase-related protein 4

      See identical proteins and their annotated locations for NP_006417.2

      Status: VALIDATED

      Source sequence(s)
      AL512622, BC029280, BC136329, BC142974
      Consensus CDS
      CCDS7665.1
      UniProtKB/Swiss-Prot
      B2RMQ1, D3DRG5, O00240, O14531, Q5T0Q7
      Related
      ENSP00000339850.3, ENST00000338492.9
      Conserved Domains (1) summary
      cd01314
      Location:17 → 466
      D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      132186948..132205759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      133128313..133148570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364500.1 → XP_054220475.1  dihydropyrimidinase-related protein 4 isoform X1

    2. XM_054364498.1 → XP_054220473.1  dihydropyrimidinase-related protein 4 isoform X1

    3. XM_054364499.1 → XP_054220474.1  dihydropyrimidinase-related protein 4 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14531.2 GenPept UniProtKB/Swiss-Prot:O14531

    Gene LinkOut

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