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    Wdr13 WD repeat domain 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317370, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Wdr13provided by RGD
    Official Full Name
    WD repeat domain 13provided by RGD
    Primary source
    RGD:1560982
    See related
    Ensembl:ENSRNOG00000039587 AllianceGenome:RGD:1560982
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560982
    Summary
    Predicted to enable promoter-specific chromatin binding activity. Predicted to act upstream of or within negative regulation of type B pancreatic cell proliferation. Predicted to be located in centriolar satellite; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Orthologous to human WDR13 (WD repeat domain 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 249.0), Heart (RPKM 175.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wdr13 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (17034779..17045682)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14362484..14373727)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15112663..15123825)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 25 Neighboring gene RNA binding motif protein 3 Neighboring gene U6 spliceosomal RNA Neighboring gene WASP actin nucleation promoting factor Neighboring gene SUV39H1 histone lysine methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Lack of Wdr13 gene in mice leads to enhanced pancreatic beta cell proliferation, hyperinsulinemia and mild obesity. Singh VP, et al. PLoS One, 2012. PMID 22715406, Free PMC Article
    2. Seven cDNAs enriched following hippocampal lesion: possible roles in neuronal responses to injury. Price M, et al. Brain Res Mol Brain Res, 2003 Sep 10. PMID 14499481
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables promoter-specific chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of type B pancreatic cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108247.3 → NP_001101717.1  WD repeat-containing protein 13 isoform 1

      See identical proteins and their annotated locations for NP_001101717.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      B2RZ63, G3V6Q3
      Conserved Domains (2) summary
      COG2319
      Location:73 → 393
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:129 → 165
      7WD40; WD40 repeat [structural motif]

    2. NM_001398749.1 → NP_001385678.1  WD repeat-containing protein 13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6KP51, G3V6Q3
      Related
      ENSRNOP00000007464.7, ENSRNOT00000007464.8
      Conserved Domains (2) summary
      COG2319
      Location:165 → 485
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:221 → 257
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      17034779..17045682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099770.2 → XP_038955698.1  WD repeat-containing protein 13 isoform X2

      UniProtKB/TrEMBL
      B2RZ63, G3V6Q3
      Conserved Domains (2) summary
      COG2319
      Location:73 → 393
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:129 → 165
      7WD40; WD40 repeat [structural motif]

    2. XM_039099769.2 → XP_038955697.1  WD repeat-containing protein 13 isoform X1

      UniProtKB/TrEMBL
      G3V6Q3
      Conserved Domains (2) summary
      COG2319
      Location:165 → 485
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:221 → 257
      7WD40; WD40 repeat [structural motif]

    3. XM_063280050.1 → XP_063136120.1  WD repeat-containing protein 13 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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