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    FN1 fibronectin 1 [ Gallus gallus (chicken) ]

    Gene ID: 396133, updated on 3-Apr-2024

    Summary

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    Official Symbol
    FN1provided by CGNC
    Official Full Name
    fibronectin 1provided by CGNC
    Primary source
    CGNC:2613
    See related
    Ensembl:ENSGALG00010011984
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    FN
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 7
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (4440758..4490944, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (4382075..4432210, complement)

    Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily A member 12 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Neighboring gene uncharacterized LOC112532769 Neighboring gene uncharacterized LOC121111289

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Radial glia produce and align the ligand fibronectin during neuronal migration in the developing chick brain. Stettler EM, et al. J Comp Neurol, 2004 Jan 12. PMID 14681936
    2. Suppression of cell adhesion and spreading activities of fibronectin by arginine-specific ADP-ribosyltransferase from chicken polymorphonuclear leukocytes. Terashima M, et al. Biochim Biophys Acta, 1998 Sep 16. PMID 9739157
    3. A highly conserved region upstream of the fibronectin alternative exon EIIIA 3' splice site interacts with cell-type-specific nuclear proteins. Norton PA, et al. Biochim Biophys Acta, 1998 Jan 21. PMID 9473640
    4. The exon encoding the fibronectin type III-9 repeat is constitutively included in the mRNA from chick limb mesenchyme and cartilage. Gehris AL, et al. Biochim Biophys Acta, 1996 Mar 27. PMID 8603103
    5. Immunocytochemical localization of fibronectin in embryonic chick trunk and area vasculosa. Mayer BW Jr, et al. Dev Biol, 1981 Mar. PMID 7014292

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Developmental Changes in Patterns of Distribution of Fibronectin and Tenascin-C in the Chicken Cornea: Evidence for Distinct and Independent Functions during Corneal Development and Morphogenesis.
      Title: Developmental Changes in Patterns of Distribution of Fibronectin and Tenascin-C in the Chicken Cornea: Evidence for Distinct and Independent Functions during Corneal Development and Morphogenesis.
    2. Thus, similarly to growth factor signaling, fibronectin matrix assembly during early development can be both autocrine and paracrine.
      Title: Fibronectin assembly during early embryo development: A versatile communication system between cells and tissues.
    3. cell rearrangements guided by a fibronectin matrix have a role in somitogenesis
      Title: Dynamic 3D cell rearrangements guided by a fibronectin matrix underlie somitogenesis.
    4. We provide a hypothesis whereby a combination of activated surface integrin levels and the degree to which those receptors are clustered determines NCC motility on fibronectin.
      Title: Neural crest motility on fibronectin is regulated by integrin activation.
    5. fibronectin is produced by radial glia and is aligned along their surfaces before and during migration
      Title: Radial glia produce and align the ligand fibronectin during neuronal migration in the developing chick brain.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables proteoglycan binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-substrate junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibronectin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198712.2 → NP_001185641.1  fibronectin precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000235
      UniProtKB/Swiss-Prot
      F1NJT3, P11722, Q90921
      UniProtKB/TrEMBL
      A0A8V0YC34
      Related
      ENSGALP00010016500.1, ENSGALT00010028696.1
      Conserved Domains (6) summary
      smart00059
      Location:418 → 466
      FN2; Fibronectin type 2 domain
      smart00058
      Location:188 → 232
      FN1; Fibronectin type 1 domain
      cd00061
      Location:53 → 91
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:2000 → 2080
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:2302 → 2341
      fn1; Fibronectin type I domain
      pfam00041
      Location:1544 → 1625
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      4440758..4490944 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046943492.1 → XP_046799448.1  fibronectin isoform X6

      Related
      ENSGALP00010016522.1, ENSGALT00010028720.1

    2. XM_046943491.1 → XP_046799447.1  fibronectin isoform X3

    3. XM_015289128.4 → XP_015144614.1  fibronectin isoform X1

      UniProtKB/TrEMBL
      A0A8V0YC34
      Conserved Domains (6) summary
      smart00059
      Location:418 → 466
      FN2; Fibronectin type 2 domain
      smart00058
      Location:188 → 232
      FN1; Fibronectin type 1 domain
      cd00061
      Location:53 → 91
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:2000 → 2080
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:2302 → 2341
      fn1; Fibronectin type I domain
      pfam00041
      Location:1544 → 1625
      fn3; Fibronectin type III domain

    4. XM_015289133.4 → XP_015144619.1  fibronectin isoform X8

      UniProtKB/TrEMBL
      A0A8V0YC34
      Conserved Domains (6) summary
      smart00059
      Location:418 → 466
      FN2; Fibronectin type 2 domain
      smart00058
      Location:188 → 232
      FN1; Fibronectin type 1 domain
      cd00061
      Location:53 → 91
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1819 → 1899
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:2121 → 2160
      fn1; Fibronectin type I domain
      pfam00041
      Location:1453 → 1534
      fn3; Fibronectin type III domain

    5. XM_015289132.4 → XP_015144618.1  fibronectin isoform X5

      UniProtKB/TrEMBL
      A0A8V0YC34, A0A8V0YDD6
      Related
      ENSGALP00010016514.1, ENSGALT00010028712.1
      Conserved Domains (6) summary
      smart00059
      Location:418 → 466
      FN2; Fibronectin type 2 domain
      smart00058
      Location:188 → 232
      FN1; Fibronectin type 1 domain
      cd00061
      Location:53 → 91
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1909 → 1989
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:2211 → 2250
      fn1; Fibronectin type I domain
      pfam00041
      Location:1453 → 1534
      fn3; Fibronectin type III domain

    6. XM_046943493.1 → XP_046799449.1  fibronectin isoform X7

    7. XM_015289131.4 → XP_015144617.1  fibronectin isoform X4

      UniProtKB/TrEMBL
      A0A8V0YC34, A0A8V0YFJ8
      Related
      ENSGALP00010016505.1, ENSGALT00010028702.1
      Conserved Domains (6) summary
      smart00059
      Location:418 → 466
      FN2; Fibronectin type 2 domain
      smart00058
      Location:188 → 232
      FN1; Fibronectin type 1 domain
      cd00061
      Location:53 → 91
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1910 → 1990
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:2212 → 2251
      fn1; Fibronectin type I domain
      pfam00041
      Location:1544 → 1625
      fn3; Fibronectin type III domain

    8. XM_015289129.4 → XP_015144615.1  fibronectin isoform X2

      UniProtKB/TrEMBL
      A0A8V0YC34
      Conserved Domains (6) summary
      smart00059
      Location:418 → 466
      FN2; Fibronectin type 2 domain
      smart00058
      Location:188 → 232
      FN1; Fibronectin type 1 domain
      cd00061
      Location:53 → 91
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:2000 → 2080
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:2258 → 2297
      fn1; Fibronectin type I domain
      pfam00041
      Location:1544 → 1625
      fn3; Fibronectin type III domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      4382075..4432210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046921137.1 → XP_046777093.1  fibronectin isoform X6

    2. XM_046921134.1 → XP_046777090.1  fibronectin isoform X3

    3. XM_046921132.1 → XP_046777088.1  fibronectin isoform X1

    4. XM_046921139.1 → XP_046777095.1  fibronectin isoform X8

    5. XM_046921136.1 → XP_046777092.1  fibronectin isoform X5

      UniProtKB/TrEMBL
      A0A8V0YDD6

    6. XM_046921138.1 → XP_046777094.1  fibronectin isoform X7

    7. XM_046921135.1 → XP_046777091.1  fibronectin isoform X4

      UniProtKB/TrEMBL
      A0A8V0YFJ8

    8. XM_046921133.1 → XP_046777089.1  fibronectin isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11722.4 GenPept UniProtKB/Swiss-Prot:P11722

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.