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    Kcnh6 potassium voltage-gated channel subfamily H member 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116745, updated on 2-May-2024

    Summary

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    Official Symbol
    Kcnh6provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily H member 6provided by RGD
    Primary source
    RGD:620304
    See related
    Ensembl:ENSRNOG00000008078 AllianceGenome:RGD:620304
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Erg2
    Summary
    Enables inward rectifier potassium channel activity. Involved in potassium ion transport. Is integral component of plasma membrane. Orthologous to human KCNH6 (potassium voltage-gated channel subfamily H member 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 7.3), Adrenal (RPKM 5.9) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcnh6 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (91449025..91471012)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (90949240..90970746)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (94207336..94228236)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095193 Neighboring gene angiotensin I converting enzyme Neighboring gene angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene translational activator of cytochrome c oxidase I

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes. Jang SW, et al. J Neurochem, 2010 Dec. PMID 21044070, Free PMC Article
    2. Fast erg K+ currents in rat embryonic serotonergic neurones. Hirdes W, et al. J Physiol, 2005 Apr 1. PMID 15677682, Free PMC Article
    3. Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain. Saganich MJ, et al. J Neurosci, 2001 Jul 1. PMID 11425889, Free PMC Article
    4. Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers. Wimmers S, et al. Pflugers Arch, 2001 Jan. PMID 11212207
    5. Identification of two nervous system-specific members of the erg potassium channel gene family. Shi W, et al. J Neurosci, 1997 Dec 15. PMID 9390998, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables inward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in membrane repolarization during cardiac muscle cell action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of heart rate by cardiac conduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of ventricular cardiac muscle cell membrane repolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    potassium voltage-gated channel subfamily H member 6
    Names
    ERG-2
    Eag-related gene member 2
    eag-related protein 2
    ether-a-go-go-related gene potassium channel 2
    ether-a-go-go-related protein 2
    potassium channel, voltage gated eag related subfamily H, member 6
    potassium voltage-gated channel, subfamily H (eag-related), member 6
    voltage-gated potassium channel subunit Kv11.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053937.1 → NP_446389.1  potassium voltage-gated channel subfamily H member 6

      See identical proteins and their annotated locations for NP_446389.1

      Status: PROVISIONAL

      Source sequence(s)
      AF016192
      UniProtKB/Swiss-Prot
      O54853
      UniProtKB/TrEMBL
      A6HJZ7, G3V720
      Related
      ENSRNOP00000010816.2, ENSRNOT00000010816.5
      Conserved Domains (6) summary
      COG0664
      Location:588 → 701
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:594 → 705
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:41 → 132
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:296 → 520
      Ion_trans; Ion transport protein
      pfam07885
      Location:463 → 517
      Ion_trans_2; Ion channel
      pfam13426
      Location:29 → 132
      PAS_9; PAS domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      91449025..91471012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247555.5 → XP_006247617.1  potassium voltage-gated channel subfamily H member 6 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GWV8, A6HJZ7, G3V720
      Related
      ENSRNOP00000076037.2
      Conserved Domains (6) summary
      COG0664
      Location:588 → 701
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:594 → 705
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:41 → 132
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:296 → 520
      Ion_trans; Ion transport protein
      pfam07885
      Location:463 → 517
      Ion_trans_2; Ion channel
      pfam13426
      Location:29 → 132
      PAS_9; PAS domain

    2. XM_039085057.2 → XP_038940985.1  potassium voltage-gated channel subfamily H member 6 isoform X3

      Conserved Domains (2) summary
      PLN03192
      Location:259 → 698
      PLN03192; Voltage-dependent potassium channel; Provisional
      pfam13426
      Location:29 → 132
      PAS_9; PAS domain

    3. XM_039085055.2 → XP_038940983.1  potassium voltage-gated channel subfamily H member 6 isoform X2

      Conserved Domains (2) summary
      PLN03192
      Location:259 → 698
      PLN03192; Voltage-dependent potassium channel; Provisional
      pfam13426
      Location:29 → 132
      PAS_9; PAS domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54853.1 GenPept UniProtKB/Swiss-Prot:O54853

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