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    LZTS2 leucine zipper tumor suppressor 2 [ Homo sapiens (human) ]

    Gene ID: 84445, updated on 5-Mar-2024

    Summary

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    Official Symbol
    LZTS2provided by HGNC
    Official Full Name
    leucine zipper tumor suppressor 2provided by HGNC
    Primary source
    HGNC:HGNC:29381
    See related
    Ensembl:ENSG00000107816 MIM:610454; AllianceGenome:HGNC:29381
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LAPSER1
    Summary
    The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
    Expression
    Ubiquitous expression in endometrium (RPKM 12.4), fat (RPKM 11.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    10q24.31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (100996588..101007833)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (101879963..101891208)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (102756345..102767590)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene semaphorin 4G Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3902 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:102755784-102756653 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2712 Neighboring gene twinkle mtDNA helicase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2713 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:102768034-102768715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:102768716-102769396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3905 Neighboring gene PDZ domain containing 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3906 Neighboring gene sideroflexin 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:102810093-102810594 Neighboring gene uncharacterized LOC107984262 Neighboring gene Sharpr-MPRA regulatory region 11881

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LZTS2: A novel and independent prognostic biomarker for clear cell renal cell carcinoma. Peng Y, et al. Pathol Res Pract, 2022 Apr. PMID 35287088
    2. LZTS2 promoter hypermethylation: a potential biomarker for the diagnosis and prognosis of laryngeal squamous cell carcinoma. Shen Z, et al. World J Surg Oncol, 2018 Mar 2. PMID 29499699, Free PMC Article
    3. LZTS2 inhibits PI3K/AKT activation and radioresistance in nasopharyngeal carcinoma by interacting with p85. Xu S, et al. Cancer Lett, 2018 Apr 28. PMID 29409973
    4. Effect of the modulation of leucine zipper tumor suppressor 2 expression on proliferation of various cancer cells functions as a tumor suppressor. Kim JM, et al. Mol Cell Biochem, 2011 Jan. PMID 20890637
    5. LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin. Thyssen G, et al. Mol Cell Biol, 2006 Dec. PMID 17000760, Free PMC Article

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LZTS2: A novel and independent prognostic biomarker for clear cell renal cell carcinoma.
      Title: LZTS2: A novel and independent prognostic biomarker for clear cell renal cell carcinoma.
    2. beta-Trcp and CK1delta-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
      Title: β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
    3. Study found that LZTS2 was downregulated in nasopharyngeal carcinoma patients and predicted poor prognosis. Functionally, we showed that LZTS2 suppresses tumorigenesis and radioresistance in nasopharyngeal carcinoma in a p85-dependent manner.
      Title: LZTS2 inhibits PI3K/AKT activation and radioresistance in nasopharyngeal carcinoma by interacting with p85.
    4. LZTS2 promoter hypermethylation is associated with laryngeal squamous cell carcinoma.
      Title: LZTS2 promoter hypermethylation: a potential biomarker for the diagnosis and prognosis of laryngeal squamous cell carcinoma.
    5. LZTS2 could inhibit cell proliferation and cell cycle transition at the G1/S phase and was implicated in the regulation of proteins associated with the canonical Wnt pathway, including GSK3B and beta-catenin through inactivating the Akt pathway.
      Title: Leucine zipper tumor suppressor 2 inhibits cell proliferation and regulates Lef/Tcf-dependent transcription through Akt/GSK3β signaling pathway in lung cancer.
    6. deletion of Lzts2 increases susceptibility to spontaneous and carcinogen-induced tumor development.
      Title: Deletion of leucine zipper tumor suppressor 2 (Lzts2) increases susceptibility to tumor development.
    7. LZTS2 is a beta-catenin-interacting protein and modulates beta-catenin signaling and localization
      Title: LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: Centrosome-related genes, genetic variation, and risk of breast cancer.
    9. LAPSER1 C terminal domain inhibits katanin(p80/p60)-mediated microtubule severing in vitro.
      Title: LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing.
    10. The reciprocal crosstalk between beta-catenin/Tcf pathway and NF-kappaB signaling in hMSCs is mediated through the regulation of lzts2 expression.
      Title: Crossregulation of beta-catenin/Tcf pathway by NF-kappaB is mediated by lzts2 in human adipose tissue-derived mesenchymal stem cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1813

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule severing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear export IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in primary ureteric bud growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spindle midzone assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ureter morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine zipper putative tumor suppressor 2
    Names
    leucine zipper, putative tumor suppressor 2
    protein LAPSER1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318099.2 → NP_001305028.1  leucine zipper putative tumor suppressor 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon and it thus differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 all encode the same isoform (a).
      Source sequence(s)
      AK298208, AL133215, BC006212, BC058938, HY037189
      Consensus CDS
      CCDS7507.1
      UniProtKB/Swiss-Prot
      B1AL14, D3DR72, Q8N3I0, Q96J79, Q96JL2, Q9BRK4
      UniProtKB/TrEMBL
      B4DP66
      Conserved Domains (2) summary
      COG1196
      Location:329 → 537
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:439 → 636
      Fez1

    2. NM_001318100.2 → NP_001305029.1  leucine zipper putative tumor suppressor 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon and it thus differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 all encode the same isoform (a).
      Source sequence(s)
      AL133215, BC006212, BC058938, CN365632
      Consensus CDS
      CCDS7507.1
      UniProtKB/Swiss-Prot
      B1AL14, D3DR72, Q8N3I0, Q96J79, Q96JL2, Q9BRK4
      UniProtKB/TrEMBL
      B4DP66
      Related
      ENSP00000416972.2, ENST00000454422.2
      Conserved Domains (2) summary
      COG1196
      Location:329 → 537
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:439 → 636
      Fez1

    3. NM_001318101.2 → NP_001305030.1  leucine zipper putative tumor suppressor 2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. This variant has an incomplete 5' UTR because there are no 5'-complete transcripts representing it, and there is splicing ambiguity at the 5' end of the gene.
      Source sequence(s)
      AL133215
      UniProtKB/Swiss-Prot
      Q9BRK4
      Conserved Domains (2) summary
      pfam06818
      Location:219 → 416
      Fez1
      pfam13851
      Location:182 → 251
      GAS; Growth-arrest specific micro-tubule binding

    4. NM_001394944.1 → NP_001381873.1  leucine zipper putative tumor suppressor 2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL133215
      Conserved Domains (2) summary
      pfam06818
      Location:219 → 416
      Fez1
      pfam13851
      Location:182 → 251
      GAS; Growth-arrest specific micro-tubule binding

    5. NM_001394945.1 → NP_001381874.1  leucine zipper putative tumor suppressor 2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL133215
      Conserved Domains (2) summary
      pfam06818
      Location:219 → 416
      Fez1
      pfam13851
      Location:182 → 251
      GAS; Growth-arrest specific micro-tubule binding

    6. NM_001394946.1 → NP_001381875.1  leucine zipper putative tumor suppressor 2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL133215
      Conserved Domains (2) summary
      pfam06818
      Location:219 → 416
      Fez1
      pfam13851
      Location:182 → 251
      GAS; Growth-arrest specific micro-tubule binding

    7. NM_001394947.1 → NP_001381876.1  leucine zipper putative tumor suppressor 2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL133215
      Conserved Domains (2) summary
      pfam06818
      Location:219 → 416
      Fez1
      pfam13851
      Location:182 → 251
      GAS; Growth-arrest specific micro-tubule binding

    8. NM_001394948.1 → NP_001381877.1  leucine zipper putative tumor suppressor 2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL133215
      Conserved Domains (2) summary
      pfam06818
      Location:219 → 416
      Fez1
      pfam13851
      Location:182 → 251
      GAS; Growth-arrest specific micro-tubule binding

    9. NM_001394949.1 → NP_001381878.1  leucine zipper putative tumor suppressor 2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL133215
      Conserved Domains (2) summary
      pfam06818
      Location:219 → 416
      Fez1
      pfam13851
      Location:182 → 251
      GAS; Growth-arrest specific micro-tubule binding

    10. NM_001394950.1 → NP_001381879.1  leucine zipper putative tumor suppressor 2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL133215
      Consensus CDS
      CCDS7507.1
      UniProtKB/Swiss-Prot
      B1AL14, D3DR72, Q8N3I0, Q96J79, Q96JL2, Q9BRK4
      UniProtKB/TrEMBL
      B4DP66
      Conserved Domains (2) summary
      COG1196
      Location:329 → 537
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:439 → 636
      Fez1

    11. NM_001394951.1 → NP_001381880.1  leucine zipper putative tumor suppressor 2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL133215
      Consensus CDS
      CCDS7507.1
      UniProtKB/Swiss-Prot
      B1AL14, D3DR72, Q8N3I0, Q96J79, Q96JL2, Q9BRK4
      UniProtKB/TrEMBL
      B4DP66
      Conserved Domains (2) summary
      COG1196
      Location:329 → 537
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:439 → 636
      Fez1

    12. NM_001394952.1 → NP_001381881.1  leucine zipper putative tumor suppressor 2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL133215
      Consensus CDS
      CCDS7507.1
      UniProtKB/Swiss-Prot
      B1AL14, D3DR72, Q8N3I0, Q96J79, Q96JL2, Q9BRK4
      UniProtKB/TrEMBL
      B4DP66
      Conserved Domains (2) summary
      COG1196
      Location:329 → 537
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:439 → 636
      Fez1

    13. NM_032429.4 → NP_115805.1  leucine zipper putative tumor suppressor 2 isoform a

      See identical proteins and their annotated locations for NP_115805.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2 and 3 all encode isoform a.
      Source sequence(s)
      AL133215, BC006212, HY039896
      Consensus CDS
      CCDS7507.1
      UniProtKB/Swiss-Prot
      B1AL14, D3DR72, Q8N3I0, Q96J79, Q96JL2, Q9BRK4
      UniProtKB/TrEMBL
      B4DP66
      Related
      ENSP00000359243.3, ENST00000370223.7
      Conserved Domains (2) summary
      COG1196
      Location:329 → 537
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:439 → 636
      Fez1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      100996588..101007833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425850.1 → XP_047281806.1  leucine zipper putative tumor suppressor 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      101879963..101891208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BRK4.2 GenPept UniProtKB/Swiss-Prot:Q9BRK4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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