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    ZNF552 zinc finger protein 552 [ Homo sapiens (human) ]

    Gene ID: 79818, updated on 7-Apr-2024

    Summary

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    Official Symbol
    ZNF552provided by HGNC
    Official Full Name
    zinc finger protein 552provided by HGNC
    Primary source
    HGNC:HGNC:26135
    See related
    Ensembl:ENSG00000178935 AllianceGenome:HGNC:26135
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 8.2), prostate (RPKM 4.1) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    19q13.43
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57807082..57814913, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60904000..60915346, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58318450..58326281, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15157 Neighboring gene zinc finger protein 776 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58280768-58281307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15159 Neighboring gene zinc finger protein 586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58297126-58297745 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58297746-58298364 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:58300764-58300910 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58309809-58310356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15160 Neighboring gene Sharpr-MPRA regulatory region 649 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58314953-58315566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58322897-58323548 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15163 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:58333533-58334033 Neighboring gene FKBP prolyl isomerase 1A pseudogene 1 Neighboring gene zinc finger protein 587B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF552, a novel human KRAB/C2H2 zinc finger protein, inhibits AP-1- and SRE-mediated transcriptional activity. Deng Y, et al. BMB Rep, 2010 Mar. PMID 20356460
    2. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
    3. Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer. Liu Y, et al. Cancer Med, 2019 Feb. PMID 30652415, Free PMC Article
    4. Genome-scale RNAi screen for host factors required for HIV replication. Zhou H, et al. Cell Host Microbe, 2008 Nov 13. PMID 18976975
    5. Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer. Salvati A, et al. Breast Cancer Res, 2022 Jul 18. PMID 35850772, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger protein 552 (ZNF552) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21603

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 552

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024762.3 → NP_079038.2  zinc finger protein 552

      See identical proteins and their annotated locations for NP_079038.2

      Status: VALIDATED

      Source sequence(s)
      AC010645, DA345819
      Consensus CDS
      CCDS12963.1
      UniProtKB/Swiss-Prot
      B3KUE9, Q6P5A6, Q9H707
      Related
      ENSP00000375582.1, ENST00000391701.1
      Conserved Domains (5) summary
      smart00349
      Location:14 → 55
      KRAB; krueppel associated box
      COG5048
      Location:243 → 407
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:298 → 318
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:339 → 362
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      57807082..57814913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259267.5 → XP_005259324.1  zinc finger protein 552 isoform X1

      See identical proteins and their annotated locations for XP_005259324.1

      UniProtKB/TrEMBL
      B7Z1H1
      Conserved Domains (5) summary
      smart00349
      Location:10 → 51
      KRAB; krueppel associated box
      COG5048
      Location:215 → 403
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:294 → 314
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:10 → 49
      KRAB; KRAB box
      pfam13465
      Location:335 → 358
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      60904000..60915346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322191.1 → XP_054178166.1  zinc finger protein 552 isoform X1

      UniProtKB/TrEMBL
      B7Z1H1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H707.2 GenPept UniProtKB/Swiss-Prot:Q9H707

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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