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    Ptpn3 protein tyrosine phosphatase, non-receptor type 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362524, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ptpn3provided by RGD
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 3provided by RGD
    Primary source
    RGD:1311363
    See related
    Ensembl:ENSRNOG00000011425 AllianceGenome:RGD:1311363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATPase binding activity; phosphotyrosine residue binding activity; and sodium channel regulator activity. Involved in liver regeneration. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and cytoplasmic side of plasma membrane. Orthologous to human PTPN3 (protein tyrosine phosphatase non-receptor type 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 122.7), Muscle (RPKM 120.1) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptpn3 in Genome Data Viewer
    Location:
    5q24
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (76703687..76822584, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (71908520..72027323, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (74248996..74368167, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ferric-chelate reductase 1-like Neighboring gene erythrocyte membrane protein band 4.1 like 4B Neighboring gene uncharacterized LOC108350978 Neighboring gene uncharacterized LOC134486937 Neighboring gene uncharacterized LOC102556038 Neighboring gene uncharacterized LOC100910620

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cardiac sodium channel Na(v)1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1. Jespersen T, et al. Biochem Biophys Res Commun, 2006 Oct 6. PMID 16930557
    2. Gene expressions of protein tyrosine phosphatases in regenerating rat liver and rat ascites hepatoma cells. Kitamura T, et al. Jpn J Cancer Res, 1995 Sep. PMID 7591957, Free PMC Article
    3. Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1. Zheng Y, et al. J Biol Chem, 2002 Nov 8. PMID 12207026
    4. Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1. Zhang SH, et al. J Biol Chem, 1999 Jun 18. PMID 10364224
    5. Subcellular localization of intracellular protein tyrosine phosphatases in T cells. Gjörloff-Wingren A, et al. Eur J Immunol, 2000 Aug. PMID 10940933

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in liver regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of membrane depolarization during action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 3
    NP_001094224.1
    XP_001059757.1
    XP_008761962.1
    XP_017449225.1
    XP_038966966.1
    XP_063144002.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100754.1 → NP_001094224.1  tyrosine-protein phosphatase non-receptor type 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      76703687..76822584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593736.3 → XP_017449225.1  tyrosine-protein phosphatase non-receptor type 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5YBL2
      Related
      ENSRNOP00000081216.1
      Conserved Domains (4) summary
      smart00295
      Location:30 → 222
      B41; Band 4.1 homologues
      cd00992
      Location:508 → 595
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:216 → 309
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      cd14600
      Location:631 → 904
      PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3

    2. XM_001059757.6 → XP_001059757.1  tyrosine-protein phosphatase non-receptor type 3 isoform X1

      See identical proteins and their annotated locations for XP_001059757.1

      UniProtKB/TrEMBL
      A0A096MJA1, A6KDS9, F1LQQ5
      Related
      ENSRNOP00000056382.3, ENSRNOT00000059627.5
      Conserved Domains (7) summary
      smart00194
      Location:754 → 1005
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:135 → 327
      B41; Band 4.1 homologues
      cd00047
      Location:777 → 1004
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:613 → 700
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:321 → 414
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00373
      Location:220 → 327
      FERM_M; FERM central domain
      pfam09379
      Location:138 → 201
      FERM_N; FERM N-terminal domain

    3. XM_063287932.1 → XP_063144002.1  tyrosine-protein phosphatase non-receptor type 3 isoform X2

    4. XM_039111038.2 → XP_038966966.1  tyrosine-protein phosphatase non-receptor type 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5YBL2
      Conserved Domains (4) summary
      smart00295
      Location:30 → 222
      B41; Band 4.1 homologues
      cd00992
      Location:508 → 595
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:216 → 309
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      cd14600
      Location:631 → 904
      PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3

    5. XM_008763740.4 → XP_008761962.1  tyrosine-protein phosphatase non-receptor type 3 isoform X4

      See identical proteins and their annotated locations for XP_008761962.1

      Conserved Domains (4) summary
      smart00194
      Location:417 → 668
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:440 → 667
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:276 → 363
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl17171
      Location:1 → 77
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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