Aplp1 amyloid beta precursor like protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aplp1provided by RGD
Official Full Name: amyloid beta precursor like protein 1provided by RGD
Primary source: RGD:69257
See related: Ensembl:ENSRNOG00000020851 AllianceGenome:RGD:69257
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561211; Aplp1_retired
Summary: Predicted to enable adrenergic receptor binding activity and identical protein binding activity. Predicted to be involved in cellular response to norepinephrine stimulus and negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within several processes, including extracellular matrix organization; mRNA polyadenylation; and regulation of translation. Predicted to be located in several cellular components, including Golgi apparatus; nucleoplasm; and perinuclear region of cytoplasm. Orthologous to human APLP1 (amyloid beta precursor like protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 1626.4) and Kidney (RPKM 53.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (94824330..94834705, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (85696880..85707215, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (88897525..88908750, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Bda13 (e-PCR)
- UniSTS:239760

RH135017 (e-PCR)
- UniSTS:218294

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-2A adrenergic receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-2A adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables alpha-2B adrenergic receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-2B adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables alpha-2C adrenergic receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-2C adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transition metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to norepinephrine stimulus	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytosolic mRNA polyadenylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of translation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: amyloid beta precursor like protein 1

Names: amyloid beta (A4) precursor-like protein 1; amyloid-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100802.2 → NP_001094272.1 amyloid beta precursor like protein 1 isoform 2

See identical proteins and their annotated locations for NP_001094272.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

B1WBV6, F1LRS5

Related

ENSRNOP00000028297.5, ENSRNOT00000028297.6

Conserved Domains (5) summary

smart00006
Location:46 → 211

A4_EXTRA; amyloid A4

pfam02177
Location:55 → 154

APP_N; Amyloid A4 N-terminal heparin-binding

pfam10515
Location:602 → 641

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12924
Location:156 → 211

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam12925
Location:289 → 471

APP_E2; E2 domain of amyloid precursor protein
NM_001399814.1 → NP_001386743.1 amyloid beta precursor like protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6J9X4, F1LRS5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

94824330..94834705 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088308.2 → XP_038944236.1 amyloid beta precursor like protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6AD03, F1LRS5

Related

ENSRNOP00000092071.1

Conserved Domains (3) summary

smart00006
Location:46 → 211

A4_EXTRA; amyloid A4

pfam12925
Location:289 → 471

APP_E2; E2 domain of amyloid precursor protein

cl41775
Location:569 → 653

JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins