SELP selectin P [Homo sapiens (human)] - Gene

Summary

Official Symbol: SELPprovided by HGNC
Official Full Name: selectin Pprovided by HGNC
Primary source: HGNC:HGNC:10721
See related: Ensembl:ENSG00000174175 MIM:173610; AllianceGenome:HGNC:10721
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD62; GRMP; PSEL; CD62P; GMP140; LECAM3; PADGEM
Summary: This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]
Expression: Broad expression in urinary bladder (RPKM 9.3), appendix (RPKM 7.3) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q24.2

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (169588849..169630124, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (168944736..168986000, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (169558087..169599362, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High expression of angiotensin-converting enzyme 2 receptor (ACE-2), transmembrane protease serine (TMPRSS), and P-selectin in platelets lead to thrombosis formation in COVID-19 patients.
Title: High expression of angiotensin-converting enzyme 2 receptor (ACE-2), transmembrane protease serine (TMPRSS), and P-selectin in platelets lead to thrombosis formation in COVID-19 patients.
PSGL-1 decorated with sialyl Lewis[a/x] promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement.
Title: PSGL-1 decorated with sialyl Lewis(a/x) promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement.
Association of the rs3917647 polymorphism of the SELP gene with malnutrition in gastric cancer.
Title: Association of the rs3917647 polymorphism of the SELP gene with malnutrition in gastric cancer.
Clinical significance of elevated soluble T-cell immunoglobulin and mucin domain 1 and soluble P-selectin in individuals with obstructive sleep apnea-hypopnea syndrome.
Title: Clinical significance of elevated soluble T-cell immunoglobulin and mucin domain 1 and soluble P-selectin in individuals with obstructive sleep apnea-hypopnea syndrome.
Virtual Screening of Protein Data Bank via Docking Simulation Identified the Role of Integrins in Growth Factor Signaling, the Allosteric Activation of Integrins, and P-Selectin as a New Integrin Ligand.
Title: Virtual Screening of Protein Data Bank via Docking Simulation Identified the Role of Integrins in Growth Factor Signaling, the Allosteric Activation of Integrins, and P-Selectin as a New Integrin Ligand.
SARS-CoV-2 Spike Proteins and Cell-Cell Communication Induce P-Selectin and Markers of Endothelial Injury, NETosis, and Inflammation in Human Lung Microvascular Endothelial Cells and Neutrophils: Implications for the Pathogenesis of COVID-19 Coagulopathy.
Title: SARS-CoV-2 Spike Proteins and Cell-Cell Communication Induce P-Selectin and Markers of Endothelial Injury, NETosis, and Inflammation in Human Lung Microvascular Endothelial Cells and Neutrophils: Implications for the Pathogenesis of COVID-19 Coagulopathy.
Plasma levels of P-selectin and future risk of incident venous thromboembolism.
Title: Plasma levels of P-selectin and future risk of incident venous thromboembolism.
Increased Platelet Activation demonstrated by Elevated CD36 and P-Selectin Expression in 1-Year Post-Recovered COVID-19 Patients.
Title: Increased Platelet Activation demonstrated by Elevated CD36 and P-Selectin Expression in 1-Year Post-Recovered COVID-19 Patients.
Differentiated serum levels of Kruppel-like factors 2 and 4, sP-selectin, and sE-selectin in patients with gestational diabetes mellitus.
Title: Differentiated serum levels of Krüppel-like factors 2 and 4, sP-selectin, and sE-selectin in patients with gestational diabetes mellitus.
The role of P-selectin in cancer-associated thrombosis and beyond.
Title: The role of P-selectin in cancer-associated thrombosis and beyond.

Submit: New GeneRIF Correction See all GeneRIFs (339)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Multiple loci influencing hippocampal degeneration identified by genome scan. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	CXCR4-tropic and CXCR4/CCR5 dual-tropic HIV-1 gp120 induce the cleavage of CD62 ligand by a mechanism dependent on matrix metalloproteinases 1 and 3, CD4, CXCR4, Galpha(i), and p38 MAPK, whereas CCR5-tropic gp120 does not	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AL033775 (e-PCR)
- UniSTS:93627

SHGC-17253 (e-PCR)
- UniSTS:53700

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables fucose binding	IDA Inferred from Direct Assay more info	PubMed
enables glycosphingolipid binding	TAS Traceable Author Statement more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables integrin binding	IDA Inferred from Direct Assay more info	PubMed
enables lipopolysaccharide binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables oligosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables oligosaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sialic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables sialic acid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-negative bacterium	IC Inferred by Curator more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in leukocyte cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in leukocyte tethering or rolling	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte tethering or rolling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of leukocyte migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of leukocyte tethering or rolling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of platelet activation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of integrin activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cytokine	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to lipopolysaccharide	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in platelet alpha granule membrane	IDA Inferred from Direct Assay more info	PubMed
located_in platelet alpha granule membrane	TAS Traceable Author Statement more info
located_in platelet dense granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: P-selectin

Names: CD62 antigen-like family member P; GMP-140; granule membrane protein 140; granule membrane protein 140kDa; granulocyte membrane protein; leukocyte-endothelial cell adhesion molecule 3; platelet activation dependent granule-external membrane protein; platelet alpha-granule membrane protein; selectin P (granule membrane protein 140kDa, antigen CD62)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012125.2 RefSeqGene

Range

5016..46291

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_003005.4 → NP_002996.2 P-selectin precursor

See identical proteins and their annotated locations for NP_002996.2

Status: REVIEWED

Source sequence(s)

BC068533, DA926598, DA994564, M25322

Consensus CDS

CCDS1282.1

UniProtKB/Swiss-Prot

P16109, Q5R344, Q8IVD1

UniProtKB/TrEMBL

A0A0S2Z509

Related

ENSP00000263686.5, ENST00000263686.11

Conserved Domains (4) summary

cd00033
Location:572 → 630

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03592
Location:42 → 160

CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)

PHA02927
Location:505 → 761

PHA02927; secreted complement-binding protein; Provisional

cd00054
Location:168 → 195

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

169588849..169630124 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047427583.1 → XP_047283539.1 P-selectin isoform X3

UniProtKB/TrEMBL

Q5R341

Related

ENSP00000399368.2, ENST00000458599.6
XM_005245440.3 → XP_005245497.1 P-selectin isoform X3

See identical proteins and their annotated locations for XP_005245497.1

UniProtKB/TrEMBL

Q5R341, Q5R345

Related

ENSP00000356760.1, ENST00000367786.6

Conserved Domains (4) summary

cd00033
Location:510 → 568

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03592
Location:42 → 160

CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)

PHA02927
Location:443 → 699

PHA02927; secreted complement-binding protein; Provisional

cd00054
Location:168 → 195

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_005245439.3 → XP_005245496.1 P-selectin isoform X2

See identical proteins and their annotated locations for XP_005245496.1

UniProtKB/TrEMBL

Q5R349

Conserved Domains (4) summary

cd00033
Location:572 → 630

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03592
Location:42 → 160

CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)

PHA02927
Location:505 → 761

PHA02927; secreted complement-binding protein; Provisional

cd00054
Location:168 → 195

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_005245438.3 → XP_005245495.1 P-selectin isoform X2

See identical proteins and their annotated locations for XP_005245495.1

UniProtKB/TrEMBL

Q5R349

Related

ENSP00000391694.2, ENST00000426706.6

Conserved Domains (4) summary

cd00033
Location:572 → 630

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03592
Location:42 → 160

CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)

PHA02927
Location:505 → 761

PHA02927; secreted complement-binding protein; Provisional

cd00054
Location:168 → 195

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_005245435.3 → XP_005245492.1 P-selectin isoform X1

See identical proteins and their annotated locations for XP_005245492.1

UniProtKB/Swiss-Prot

P16109, Q5R344, Q8IVD1

UniProtKB/TrEMBL

A0A0S2Z509

Conserved Domains (4) summary

cd00033
Location:572 → 630

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03592
Location:42 → 160

CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)

PHA02927
Location:505 → 761

PHA02927; secreted complement-binding protein; Provisional

cd00054
Location:168 → 195

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_005245436.5 → XP_005245493.1 P-selectin isoform X1

See identical proteins and their annotated locations for XP_005245493.1

UniProtKB/Swiss-Prot

P16109, Q5R344, Q8IVD1

UniProtKB/TrEMBL

A0A0S2Z509

Conserved Domains (4) summary

cd00033
Location:572 → 630

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03592
Location:42 → 160

CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)

PHA02927
Location:505 → 761

PHA02927; secreted complement-binding protein; Provisional

cd00054
Location:168 → 195

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...