Wdr33 WD repeat domain 33 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr33provided by MGI
Official Full Name: WD repeat domain 33provided by MGI
Primary source: MGI:MGI:1921570
See related: Ensembl:ENSMUSG00000024400 AllianceGenome:MGI:1921570
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: WDC146; 1110001N06Rik; 2310011G05Rik; 2810021O11Rik; 8430413N20Rik
Summary: Predicted to be involved in mRNA polyadenylation. Predicted to act upstream of or within mRNA processing. Located in nucleus. Orthologous to human WDR33 (WD repeat domain 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 5.8), limb E14.5 (RPKM 5.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B1; 18 17.85 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (31937079..32042040)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (31804057..31908987)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

MARC_7291-7292:992008311:1 (e-PCR)
- UniSTS:231313

MARC_7291-7292:996687736:1 (e-PCR)
- UniSTS:231313

PMC150726P5 (e-PCR)
- UniSTS:271077

Gstm2 (e-PCR), detects polymorphism
- UniSTS:526844

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in mRNA 3'-end processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
part_of mRNA cleavage and polyadenylation specificity factor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pre-mRNA 3' end processing protein WDR33

Names: WD repeat-containing protein 33; WD repeat-containing protein WDC146; WD repeat-containing protein of 146 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170966.1 → NP_001164437.1 pre-mRNA 3' end processing protein WDR33 isoform 4

See identical proteins and their annotated locations for NP_001164437.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) has multiple differences, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC124393, AC161511, AK045923

Consensus CDS

CCDS89211.1

UniProtKB/TrEMBL

Q8BRC5, Q9D1P6

Related

ENSMUSP00000157238.2, ENSMUST00000234344.2

Conserved Domains (3) summary

COG2319
Location:127 → 219

WD40; WD40 repeat [General function prediction only]

sd00039
Location:122 → 158

7WD40; WD40 repeat [structural motif]

cl02567
Location:119 → 205

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001170967.1 → NP_001164438.1 pre-mRNA 3' end processing protein WDR33 isoform 3

See identical proteins and their annotated locations for NP_001164438.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has multiple differences, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC124393, AC161511, AK078286

Consensus CDS

CCDS89210.1

UniProtKB/TrEMBL

D3YX80, Q8K1G7

Related

ENSMUSP00000080936.9, ENSMUST00000082319.15

Conserved Domains (3) summary

COG2319
Location:104 → 231

WD40; WD40 repeat [General function prediction only]

sd00039
Location:122 → 159

7WD40; WD40 repeat [structural motif]

cl02567
Location:119 → 230

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001170970.1 → NP_001164441.1 pre-mRNA 3' end processing protein WDR33 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC124393, AC161511, AK009297

Consensus CDS

CCDS50242.1

UniProtKB/TrEMBL

A0A3Q4EGD8

Related

ENSMUSP00000157157.2, ENSMUST00000234957.2

Conserved Domains (2) summary

sd00039
Location:122 → 159

7WD40; WD40 repeat [structural motif]

cl29593
Location:119 → 230

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_028866.3 → NP_083142.2 pre-mRNA 3' end processing protein WDR33 isoform 1

See identical proteins and their annotated locations for NP_083142.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC124393, AC131761, AC161511

Consensus CDS

CCDS29112.1

UniProtKB/Swiss-Prot

Q8C7C6, Q8CD02, Q8K4P0

Related

ENSMUSP00000025264.7, ENSMUST00000025264.8

Conserved Domains (5) summary

pfam01391
Location:717 → 769

Collagen; Collagen triple helix repeat (20 copies)

COG2319
Location:121 → 405

WD40; WD40 repeat [General function prediction only]

cd00200
Location:121 → 402

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam09606
Location:602 → 963

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

sd00039
Location:122 → 159

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

31937079..32042040

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526300.2 → XP_006526363.1 pre-mRNA 3' end processing protein WDR33 isoform X2

Conserved Domains (4) summary

cd00200
Location:121 → 402

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:122 → 159

7WD40; WD40 repeat [structural motif]

pfam09606
Location:590 → 926

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cl26593
Location:537 → 640

DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)
XM_006526301.2 → XP_006526364.1 pre-mRNA 3' end processing protein WDR33 isoform X3

Conserved Domains (3) summary

cd00200
Location:121 → 402

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:122 → 159

7WD40; WD40 repeat [structural motif]

pfam09606
Location:590 → 926

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
XM_006526298.2 → XP_006526361.1 pre-mRNA 3' end processing protein WDR33 isoform X1

Conserved Domains (4) summary

cd00200
Location:121 → 402

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:122 → 159

7WD40; WD40 repeat [structural motif]

pfam09606
Location:590 → 926

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cl26593
Location:537 → 640

DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)
XM_036161297.1 → XP_036017190.1 pre-mRNA 3' end processing protein WDR33 isoform X5

Conserved Domains (2) summary

sd00039
Location:122 → 159

7WD40; WD40 repeat [structural motif]

cl29593
Location:119 → 230

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_017317996.3 → XP_017173485.1 pre-mRNA 3' end processing protein WDR33 isoform X1

Conserved Domains (4) summary

cd00200
Location:121 → 402

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:122 → 159

7WD40; WD40 repeat [structural motif]

pfam09606
Location:590 → 926

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cl26593
Location:537 → 640

DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)
XM_036161296.1 → XP_036017189.1 pre-mRNA 3' end processing protein WDR33 isoform X4

UniProtKB/TrEMBL

A0A3Q4EGD8

Conserved Domains (2) summary

sd00039
Location:122 → 159

7WD40; WD40 repeat [structural motif]

cl29593
Location:119 → 230

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...