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    atk artichoke [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40266, updated on 26-Apr-2024

    Summary

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    Official Symbol
    atkprovided by FlyBase
    Official Full Name
    artichokeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036995
    Locus tag
    Dmel_CG5195
    See related
    AllianceGenome:FB:FBgn0036995
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5195; CT16609; Dmel\CG5195; tartan/capricious-like
    Summary
    Involved in cilium assembly; locomotion; and sensory organ development. Located in cytoplasm and extracellular matrix. Is expressed in embryonic/larval peripheral nervous system and sense organ. Orthologous to human LRG1 (leucine rich alpha-2-glycoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    77C3-77C4; 3-47 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20454690..20464862, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20447790..20457962, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U snoRNA host gene 8 Neighboring gene magro Neighboring gene uncharacterized protein Neighboring gene L-threonine dehydrogenase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Decreased cerebral Irp-1B limits impact of social isolation in wild type and Alzheimer's disease modeled in Drosophila melanogaster. Ruland C, et al. Genes Brain Behav, 2018 Jun. PMID 29251829
    2. The extracellular matrix protein artichoke is required for integrity of ciliated mechanosensory and chemosensory organs in Drosophila embryos. Andrés M, et al. Genetics, 2014 Apr. PMID 24496014, Free PMC Article
    3. Drosophila convoluted/dALS is an essential gene required for tracheal tube morphogenesis and apical matrix organization. Swanson LE, et al. Genetics, 2009 Apr. PMID 19171940, Free PMC Article
    4. Form and function of the apical extracellular matrix: new insights from Caenorhabditis elegans, Drosophila melanogaster, and the vertebrate inner ear. Li Zheng S, et al. Fac Rev, 2020. PMID 33659959, Free PMC Article
    5. Bioinformatic analysis suggests potential mechanisms underlying parasitoid venom evolution and function. Alvarado G, et al. Genomics, 2020 Mar. PMID 31247332

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    artichoke
    Names
    CG5195-PA
    CG5195-PB
    CG5195-PC
    atk-PA
    atk-PB
    atk-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20454690..20464862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275185.1 → NP_001262114.1  artichoke, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262114.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E3CTU4, F0JAL6, Q6NR19, Q9VPF0
      Conserved Domains (6) summary
      cd00116
      Location:250 → 492
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:505 → 517
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:525 → 550
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:209 → 247
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:622 → 681
      LRR_8; Leucine rich repeat
      cl15307
      Location:919 → 946
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    2. NM_140971.1 → NP_649228.1  artichoke, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649228.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E3CTU4, F0JAL6, Q6NR19, Q9VPF0
      Related
      FBpp0077881, FBtr0078223
      Conserved Domains (6) summary
      cd00116
      Location:250 → 492
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:505 → 517
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:525 → 550
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:209 → 247
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:622 → 681
      LRR_8; Leucine rich repeat
      cl15307
      Location:919 → 946
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    3. NM_001275184.1 → NP_001262113.1  artichoke, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262113.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E3CTU4, F0JAL6, Q6NR19, Q9VPF0
      Conserved Domains (6) summary
      cd00116
      Location:250 → 492
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:505 → 517
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:525 → 550
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:209 → 247
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:622 → 681
      LRR_8; Leucine rich repeat
      cl15307
      Location:919 → 946
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPF0.2 Q9VPF0

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