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    Dnajc6 DnaJ heat shock protein family (Hsp40) member C6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313409, updated on 2-May-2024

    Summary

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    Official Symbol
    Dnajc6provided by RGD
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C6provided by RGD
    Primary source
    RGD:1309900
    See related
    Ensembl:ENSRNOG00000052887 AllianceGenome:RGD:1309900
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatase activity. Predicted to be involved in synaptic vesicle uncoating. Predicted to act upstream of or within clathrin coat disassembly and regulation of clathrin-dependent endocytosis. Predicted to be located in postsynaptic density. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 19A. Orthologous to human DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 363.6), Kidney (RPKM 45.6) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnajc6 in Genome Data Viewer
    Location:
    5q33
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (121232532..121398775)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (116120069..116283448)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (120330372..120492515)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479017 Neighboring gene adenylate kinase 4 Neighboring gene uncharacterized LOC134479018 Neighboring gene uncharacterized LOC120102936 Neighboring gene leptin receptor overlapping transcript Neighboring gene leptin receptor Neighboring gene oogenesin 3, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A sequential mechanism for clathrin cage disassembly by 70-kDa heat-shock cognate protein (Hsc70) and auxilin. Rothnie A, et al. Proc Natl Acad Sci U S A, 2011 Apr 26. PMID 21482805, Free PMC Article
    2. Multiple roles for cyclin G-associated kinase in clathrin-mediated sorting events. Zhang CX, et al. Traffic, 2005 Dec. PMID 16262722
    3. Synaptojanin 1 mutation in Parkinson's disease brings further insight into the neuropathological mechanisms. Drouet V, et al. Biomed Res Int, 2014. PMID 25302295, Free PMC Article
    4. MiR-3120 is a mirror microRNA that targets heat shock cognate protein 70 and auxilin messenger RNAs and regulates clathrin vesicle uncoating. Scott H, et al. J Biol Chem, 2012 Apr 27. PMID 22393045, Free PMC Article
    5. Impaired intracellular trafficking defines early Parkinson's disease. Hunn BH, et al. Trends Neurosci, 2015 Mar. PMID 25639775, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-3120 was found to be located in neuronal cell bodies and to target Hsc70 and auxilin, and its lentivirus-mediated expression inhibited the uncoating of clathrin-coated vesicles.
      Title: MiR-3120 is a mirror microRNA that targets heat shock cognate protein 70 and auxilin messenger RNAs and regulates clathrin vesicle uncoating.
    2. A sequential mechanism for clathrin cage disassembly by 70-kDa heat-shock cognate protein (Hsc70) and auxilin.
      Title: A sequential mechanism for clathrin cage disassembly by 70-kDa heat-shock cognate protein (Hsc70) and auxilin.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within clathrin coat disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle uncoating ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extrinsic component of presynaptic endocytic zone membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    putative tyrosine-protein phosphatase auxilin
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 6
    NP_001402850.1
    XP_006238509.3
    XP_006238510.1
    XP_006238511.1
    XP_038965846.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415921.1 → NP_001402850.1  putative tyrosine-protein phosphatase auxilin

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6AMT9
      Related
      ENSRNOP00000095523.1, ENSRNOT00000113921.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      121232532..121398775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238447.5 → XP_006238509.3  putative tyrosine-protein phosphatase auxilin isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWX0, A0A8I6A6P4
      Related
      ENSRNOP00000086865.1
      Conserved Domains (4) summary
      cd06257
      Location:892 → 937
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      PHA03247
      Location:565 → 796
      PHA03247; large tegument protein UL36; Provisional
      cd14563
      Location:87 → 249
      PTP_auxilin_N; N-terminal protein tyrosine phosphatase-like domain of auxilin
      pfam10409
      Location:257 → 395
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    2. XM_039109918.2 → XP_038965846.1  putative tyrosine-protein phosphatase auxilin isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZWX0
      Related
      ENSRNOP00000084012.1
      Conserved Domains (4) summary
      cd06257
      Location:848 → 893
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      PHA03247
      Location:521 → 752
      PHA03247; large tegument protein UL36; Provisional
      cd14563
      Location:43 → 205
      PTP_auxilin_N; N-terminal protein tyrosine phosphatase-like domain of auxilin
      pfam10409
      Location:213 → 351
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    3. XM_006238448.5 → XP_006238510.1  putative tyrosine-protein phosphatase auxilin isoform X2

      UniProtKB/TrEMBL
      A0A0G2JY26, A6JRN8, D4A0I5
      Related
      ENSRNOP00000070493.1
      Conserved Domains (2) summary
      cd06257
      Location:886 → 931
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam10409
      Location:251 → 389
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    4. XM_006238449.5 → XP_006238511.1  putative tyrosine-protein phosphatase auxilin isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZWX0
      Conserved Domains (4) summary
      cd06257
      Location:848 → 893
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      PHA03247
      Location:521 → 752
      PHA03247; large tegument protein UL36; Provisional
      cd14563
      Location:43 → 205
      PTP_auxilin_N; N-terminal protein tyrosine phosphatase-like domain of auxilin
      pfam10409
      Location:213 → 351
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107949.5: Suppressed sequence

      Description
      NM_001107949.5: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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