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    Lrrc2 leucine rich repeat containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301033, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Lrrc2provided by RGD
    Official Full Name
    leucine rich repeat containing 2provided by RGD
    Primary source
    RGD:1311716
    See related
    Ensembl:ENSRNOG00000030688 AllianceGenome:RGD:1311716
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Orthologous to human LRRC2 (leucine rich repeat containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 383.5) and Muscle (RPKM 237.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    8q32
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (119814514..119847587)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (110936119..110969189)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (119226651..119259649)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 like 4 Neighboring gene cripto, EGF-CFC family member Neighboring gene receptor (chemosensory) transporter protein 3 Neighboring gene elongin B like 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393940.2 → NP_001380869.1  leucine-rich repeat-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      Q5U2S4
      Conserved Domains (2) summary
      COG4886
      Location:98 → 323
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:123 → 145
      LRR_RI; leucine-rich repeat [structural motif]

    RNA

    1. NR_172058.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      119814514..119847587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595598.3 → XP_017451087.1  leucine-rich repeat-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      F7F213
      Conserved Domains (3) summary
      sd00033
      Location:131 → 153
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:175 → 209
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:153 → 209
      LRR_8; Leucine rich repeat

    2. XM_006243926.5 → XP_006243988.1  leucine-rich repeat-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      F7F213
      Related
      ENSRNOP00000046666.4
      Conserved Domains (3) summary
      sd00033
      Location:131 → 153
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:175 → 209
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:153 → 209
      LRR_8; Leucine rich repeat

    3. XM_039081252.2 → XP_038937180.1  leucine-rich repeat-containing protein 2 isoform X3

      Conserved Domains (2) summary
      COG4886
      Location:106 → 261
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:131 → 153
      LRR_RI; leucine-rich repeat [structural motif]

    4. XM_039081251.2 → XP_038937179.1  leucine-rich repeat-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      Q5U2S4
      Conserved Domains (2) summary
      COG4886
      Location:98 → 323
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:123 → 145
      LRR_RI; leucine-rich repeat [structural motif]

    5. XM_039081253.2 → XP_038937181.1  leucine-rich repeat-containing protein 2 isoform X4

      Conserved Domains (2) summary
      COG4886
      Location:2 → 161
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:2 → 23
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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