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    Cnot10 CCR4-NOT transcription complex, subunit 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316034, updated on 2-May-2024

    Summary

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    Official Symbol
    Cnot10provided by RGD
    Official Full Name
    CCR4-NOT transcription complex, subunit 10provided by RGD
    Primary source
    RGD:1359219
    See related
    Ensembl:ENSRNOG00000052305 AllianceGenome:RGD:1359219
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in mRNA catabolic process and negative regulation of translation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of CCR4-NOT complex. Orthologous to human CNOT10 (CCR4-NOT transcription complex subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 212.5), Testes (RPKM 166.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    8q32
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (123158675..123208389, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (114280486..114330110, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (122634681..122696466, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine receptor 4 Neighboring gene tripartite motif containing 71 Neighboring gene uncharacterized LOC120094278 Neighboring gene ribosomal protein L30, pseudogene 11 Neighboring gene U6 spliceosomal RNA Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134480242 Neighboring gene dynein cytoplasmic 1 light intermediate chain 1 Neighboring gene CKLF-like MARVEL transmembrane domain containing 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex. Mauxion F, et al. RNA Biol, 2013 Feb. PMID 23232451, Free PMC Article
    2. RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3 complexes. Wahle E, et al. Biochim Biophys Acta, 2013 Jun-Jul. PMID 23337855
    3. Human Ccr4-Not complexes contain variable deadenylase subunits. Lau NC, et al. Biochem J, 2009 Aug 27. PMID 19558367
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94752

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCR4-NOT complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of CCR4-NOT complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT transcription complex subunit 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007003.1 → NP_001007004.1  CCR4-NOT transcription complex subunit 10

      See identical proteins and their annotated locations for NP_001007004.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083782
      UniProtKB/Swiss-Prot
      Q5XIA4
      UniProtKB/TrEMBL
      A0A0G2K8P0
      Related
      ENSRNOP00000094829.1, ENSRNOT00000104715.1
      Conserved Domains (2) summary
      COG0457
      Location:59 → 274
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:296 → 321
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      123158675..123208389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081626.2 → XP_038937554.1  CCR4-NOT transcription complex subunit 10 isoform X8

      UniProtKB/TrEMBL
      A0A0G2K8P0, A6I3P1
      Conserved Domains (1) summary
      sd00006
      Location:296 → 321
      TPR; TPR repeat [structural motif]

    2. XM_063265636.1 → XP_063121706.1  CCR4-NOT transcription complex subunit 10 isoform X9

    3. XM_039081627.2 → XP_038937555.1  CCR4-NOT transcription complex subunit 10 isoform X11

      UniProtKB/TrEMBL
      A0A0G2K8P0
      Conserved Domains (2) summary
      sd00006
      Location:242 → 267
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:242 → 271
      TPR_1; Tetratricopeptide repeat

    4. XM_039081628.2 → XP_038937556.1  CCR4-NOT transcription complex subunit 10 isoform X13

      UniProtKB/TrEMBL
      A0A0G2K8P0
      Conserved Domains (1) summary
      sd00006
      Location:196 → 221
      TPR; TPR repeat [structural motif]

    5. XM_063265638.1 → XP_063121708.1  CCR4-NOT transcription complex subunit 10 isoform X12

    6. XM_063265637.1 → XP_063121707.1  CCR4-NOT transcription complex subunit 10 isoform X10

    7. XM_039081625.2 → XP_038937553.1  CCR4-NOT transcription complex subunit 10 isoform X7

      UniProtKB/TrEMBL
      A0A0G2K7B7, A0A0G2K8P0
      Related
      ENSRNOP00000074139.2
      Conserved Domains (1) summary
      sd00006
      Location:296 → 321
      TPR; TPR repeat [structural motif]

    8. XM_039081624.2 → XP_038937552.1  CCR4-NOT transcription complex subunit 10 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K8P0
      Conserved Domains (2) summary
      sd00006
      Location:301 → 326
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:301 → 330
      TPR_1; Tetratricopeptide repeat

    9. XM_039081623.2 → XP_038937551.1  CCR4-NOT transcription complex subunit 10 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K8P0
      Conserved Domains (2) summary
      COG0457
      Location:118 → 333
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:355 → 380
      TPR; TPR repeat [structural motif]

    10. XM_063265635.1 → XP_063121705.1  CCR4-NOT transcription complex subunit 10 isoform X5

    11. XM_039081620.2 → XP_038937548.1  CCR4-NOT transcription complex subunit 10 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8P0
      Conserved Domains (2) summary
      COG0457
      Location:118 → 333
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:355 → 380
      TPR; TPR repeat [structural motif]

    12. XM_039081622.2 → XP_038937550.1  CCR4-NOT transcription complex subunit 10 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K8P0
      Conserved Domains (2) summary
      COG0457
      Location:118 → 333
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:355 → 380
      TPR; TPR repeat [structural motif]

    13. XM_039081621.2 → XP_038937549.1  CCR4-NOT transcription complex subunit 10 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K8P0, A0A8I5Y6C7
      Related
      ENSRNOP00000077810.1
      Conserved Domains (2) summary
      COG0457
      Location:118 → 333
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:355 → 380
      TPR; TPR repeat [structural motif]

    14. XM_039081630.2 → XP_038937558.1  CCR4-NOT transcription complex subunit 10 isoform X15

      Conserved Domains (3) summary
      COG0457
      Location:118 → 333
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:355 → 380
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:355 → 384
      TPR_1; Tetratricopeptide repeat

    15. XM_039081629.2 → XP_038937557.1  CCR4-NOT transcription complex subunit 10 isoform X14

      Conserved Domains (3) summary
      COG0457
      Location:118 → 333
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:355 → 380
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:355 → 384
      TPR_1; Tetratricopeptide repeat

    16. XM_063265639.1 → XP_063121709.1  CCR4-NOT transcription complex subunit 10 isoform X16

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIA4.1 GenPept UniProtKB/Swiss-Prot:Q5XIA4

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