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    Lrrn4 leucine rich repeat neuronal 4 [ Mus musculus (house mouse) ]

    Gene ID: 320974, updated on 4-May-2024

    Summary

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    Official Symbol
    Lrrn4provided by MGI
    Official Full Name
    leucine rich repeat neuronal 4provided by MGI
    Primary source
    MGI:MGI:2445154
    See related
    Ensembl:ENSMUSG00000043110 AllianceGenome:MGI:2445154
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nlrr4; B430119L13Rik
    Summary
    Acts upstream of or within long-term memory and visual learning. Is integral component of plasma membrane. Is expressed in intraembryonic coelom; midgut; reproductive system; and urogenital sinus. Orthologous to human LRRN4 (leucine rich repeat neuronal 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 11.4), ovary adult (RPKM 9.1) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 F2; 2 64.78 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (132710436..132735930, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132866686..132894010, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4502 Neighboring gene tRNA methyltransferase 6 Neighboring gene minichromosome maintenance 8 homologous recombination repair factor Neighboring gene STARR-positive B cell enhancer ABC_E10152 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:132672271-132672472 Neighboring gene cardiolipin synthase 1 Neighboring gene predicted gene, 54154 Neighboring gene STARR-positive B cell enhancer ABC_E9534 Neighboring gene fermitin family member 1 Neighboring gene predicted gene 14102 Neighboring gene predicted gene, 25704

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression pattern of leucine-rich repeat neuronal protein 4 in adult mouse dorsal root ganglia. Bando T, et al. Neurosci Lett, 2012 Nov 30. PMID 23069668
    2. Neuronal leucine-rich repeat protein 4 functions in hippocampus-dependent long-lasting memory. Bando T, et al. Mol Cell Biol, 2005 May. PMID 15870286, Free PMC Article
    3. Dynamic expression pattern of leucine-rich repeat neuronal protein 4 in the mouse dorsal root ganglia during development. Bando T, et al. Neurosci Lett, 2013 Aug 26. PMID 23701859
    4. Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages. Feng W, et al. Nat Commun, 2022 Dec 27. PMID 36575170, Free PMC Article
    5. A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. Nishino J, et al. Elife, 2013 Nov 5. PMID 24192035, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The spatiotemporal expression pattern of Lrrn4 contributes to the development of synaptic function in the DRG neurons.
      Title: Dynamic expression pattern of leucine-rich repeat neuronal protein 4 in the mouse dorsal root ganglia during development.
    2. Lrrn4 is expressed in a subset of nociceptive neurons and might contribute to the maintenance of nociceptive circuits.
      Title: Expression pattern of leucine-rich repeat neuronal protein 4 in adult mouse dorsal root ganglia.
    3. results suggest that NLRR4 plays a key role in hippocampus-dependent long-lasting memory
      Title: Neuronal leucine-rich repeat protein 4 functions in hippocampus-dependent long-lasting memory.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Gene trapped (1) 
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in long-term memory IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within visual learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine-rich repeat neuronal protein 4
    Names
    NLRR-4
    neuronal leucine rich repeat-4
    neuronal leucine-rich repeat protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177303.4 → NP_796277.2  leucine-rich repeat neuronal protein 4 precursor

      See identical proteins and their annotated locations for NP_796277.2

      Status: PROVISIONAL

      Source sequence(s)
      AK080889
      Consensus CDS
      CCDS16780.1
      UniProtKB/Swiss-Prot
      A2ANX0, P59383
      UniProtKB/TrEMBL
      Q6EI14
      Related
      ENSMUSP00000057005.3, ENSMUST00000049787.3
      Conserved Domains (5) summary
      COG4886
      Location:63 → 292
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:303 → 315
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:63 → 83
      LRR_RI; leucine-rich repeat [structural motif]
      pfam03326
      Location:347 → 541
      Herpes_TAF50; Herpesvirus transcription activation factor (transactivator)
      pfam00041
      Location:578 → 657
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      132710436..132735930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239602.3 → XP_011237904.1  leucine-rich repeat neuronal protein 4 isoform X1

      See identical proteins and their annotated locations for XP_011237904.1

      UniProtKB/Swiss-Prot
      A2ANX0, P59383
      UniProtKB/TrEMBL
      Q6EI14
      Conserved Domains (5) summary
      COG4886
      Location:63 → 292
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:303 → 315
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:63 → 83
      LRR_RI; leucine-rich repeat [structural motif]
      pfam03326
      Location:347 → 541
      Herpes_TAF50; Herpesvirus transcription activation factor (transactivator)
      pfam00041
      Location:578 → 657
      fn3; Fibronectin type III domain

    2. XM_030251770.2 → XP_030107630.1  leucine-rich repeat neuronal protein 4 isoform X2

      Conserved Domains (2) summary
      pfam03326
      Location:116 → 310
      Herpes_TAF50; Herpesvirus transcription activation factor (transactivator)
      pfam00041
      Location:347 → 426
      fn3; Fibronectin type III domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59383.2 GenPept UniProtKB/Swiss-Prot:P59383

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