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    RNF181 ring finger protein 181 [ Homo sapiens (human) ]

    Gene ID: 51255, updated on 3-Apr-2024

    Summary

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    Official Symbol
    RNF181provided by HGNC
    Official Full Name
    ring finger protein 181provided by HGNC
    Primary source
    HGNC:HGNC:28037
    See related
    Ensembl:ENSG00000168894 MIM:612490; AllianceGenome:HGNC:28037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSPC238
    Summary
    RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]).[supplied by OMIM, Dec 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 21.9), placenta (RPKM 18.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    2p11.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (85595745..85597708)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (85597805..85599768)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85822868..85824831)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16133 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85806777-85807430 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85807431-85808085 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85808086-85808739 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85811231-85812186 Neighboring gene vesicle associated membrane protein 8 Neighboring gene vesicle associated membrane protein 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85819815-85820316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85820317-85820816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11705 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11706 Neighboring gene transmembrane protein 150A Neighboring gene ubiquitin specific peptidase 39 Neighboring gene chromosome 2 open reading frame 68 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:85838960-85839341

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RN181 is a tumour suppressor in gastric cancer by regulation of the ERK/MAPK-cyclin D1/CDK4 pathway. Wang S, et al. J Pathol, 2019 Jun. PMID 30714150, Free PMC Article
    2. RN181 suppresses hepatocellular carcinoma growth by inhibition of the ERK/MAPK pathway. Wang S, et al. Hepatology, 2011 Jun. PMID 21391225
    3. [Construction of recombinant eukaryotic expression vector pDsRed1-C3/LOC51255 and subcellular localization of LOC51255 protein in HePG2 cell line]. Huang X, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2009 May. PMID 19426595
    4. RN181 regulates the biological behaviors of oral squamous cell carcinoma cells via mediating ERK/MAPK signaling pathway. Li Y, et al. Acta Histochem, 2021 Jul. PMID 34052676
    5. The ubiquitin ligase RNF181 stabilizes ERα and modulates breast cancer progression. Zhu J, et al. Oncogene, 2020 Oct. PMID 32973333, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RN181 regulates the biological behaviors of oral squamous cell carcinoma cells via mediating ERK/MAPK signaling pathway.
      Title: RN181 regulates the biological behaviors of oral squamous cell carcinoma cells via mediating ERK/MAPK signaling pathway.
    2. The ubiquitin ligase RNF181 stabilizes ERalpha and modulates breast cancer progression.
      Title: The ubiquitin ligase RNF181 stabilizes ERα and modulates breast cancer progression.
    3. RN181 functions as a tumour suppressor in gastric cancer by regulation of the ERK/MAPK-cyclin D1/CDK4 pathway, controlling cell proliferation and tumor volume.
      Title: RN181 is a tumour suppressor in gastric cancer by regulation of the ERK/MAPK-cyclin D1/CDK4 pathway.
    4. The identification and validation of proteins interacting with HSP238 may lead to the discovery of novel mechanisms through which HSPC238 suppresses tumorigenesis in human hepatocellular carcinoma
      Title: Screening and verification of proteins that interact with HSPC238.
    5. RNF181 limits the proliferation of human diffuse large B cell lymphoma cells that depend upon aberrant CARD11 signaling to NF-kappaB for growth and survival in culture.
      Title: Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181.
    6. RN181 suppresses the tumorigenesis of hepatocellular carcinoma through the inhibition of ERK/MAPK signaling in the liver.
      Title: RN181 suppresses hepatocellular carcinoma growth by inhibition of the ERK/MAPK pathway.
    7. Data show LOC51255 (RNF181) protein located in the cytoplasm of HePG2 cell line.
      Title: [Construction of recombinant eukaryotic expression vector pDsRed1-C3/LOC51255 and subcellular localization of LOC51255 protein in HePG2 cell line].
    8. The presence of RN181 in human platelets was established; RN181 has ubiquitin E3 ligase activity.
      Title: RN181, a novel ubiquitin E3 ligase that interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF181
    Names
    RING-type E3 ubiquitin transferase RNF181
    NP_057578.1
    XP_005264416.1
    XP_054198392.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016494.4 → NP_057578.1  E3 ubiquitin-protein ligase RNF181

      See identical proteins and their annotated locations for NP_057578.1

      Status: VALIDATED

      Source sequence(s)
      AC016753, BC002803
      Consensus CDS
      CCDS1981.1
      UniProtKB/Swiss-Prot
      Q53H81, Q9P0P0
      UniProtKB/TrEMBL
      C9J1C6
      Related
      ENSP00000306906.4, ENST00000306368.9
      Conserved Domains (1) summary
      cd16669
      Location:75 → 120
      RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      85595745..85597708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264359.5 → XP_005264416.1  E3 ubiquitin-protein ligase RNF181 isoform X1

      UniProtKB/TrEMBL
      H7C426
      Related
      ENSP00000415246.1, ENST00000456023.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      85597805..85599768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342417.1 → XP_054198392.1  E3 ubiquitin-protein ligase RNF181 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P0P0.1 GenPept UniProtKB/Swiss-Prot:Q9P0P0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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