Eml4 EMAP like 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eml4provided by RGD
Official Full Name: EMAP like 4provided by RGD
Primary source: RGD:1304690
See related: Ensembl:ENSRNOG00000030294 AllianceGenome:RGD:1304690
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable alpha-tubulin binding activity; beta-tubulin binding activity; and microtubule binding activity. Predicted to be involved in attachment of spindle microtubules to kinetochore; microtubule cytoskeleton organization; and mitotic metaphase plate congression. Predicted to act upstream of or within negative regulation of microtubule depolymerization. Predicted to be located in cytoplasm; microtubule cytoskeleton; and midbody. Predicted to colocalize with mitotic spindle. Orthologous to human EML4 (EMAP like 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 208.3), Spleen (RPKM 194.5) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 6q12

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (16972054..17087365, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (11219545..11334824, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (6618370..6674550)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

AI644019 (e-PCR)
- UniSTS:181071

RH138441 (e-PCR)
- UniSTS:220528

RH140067 (e-PCR)
- UniSTS:222148

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
colocalizes_with mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: echinoderm microtubule-associated protein-like 4

Names: echinoderm microtubule associated protein like 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108008.1 → NP_001101478.1 echinoderm microtubule-associated protein-like 4

See identical proteins and their annotated locations for NP_001101478.1

Status: PROVISIONAL

Source sequence(s)

CH473947

UniProtKB/TrEMBL

A6H9N0, A6H9N1

Conserved Domains (4) summary

COG2319
Location:179 → 628

WD40; WD40 repeat [General function prediction only]

pfam03451
Location:113 → 182

HELP; HELP motif

sd00039
Location:524 → 559

7WD40; WD40 repeat [structural motif]

cl02567
Location:388 → 749

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

16972054..17087365 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112153.2 → XP_038968081.1 echinoderm microtubule-associated protein-like 4 isoform X6

UniProtKB/TrEMBL

A6H9N0

Conserved Domains (4) summary

sd00039
Location:537 → 572

7WD40; WD40 repeat [structural motif]

pfam03451
Location:124 → 195

HELP; HELP motif

cd21950
Location:6 → 64

TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4

cl29593
Location:401 → 762

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_039112152.2 → XP_038968080.1 echinoderm microtubule-associated protein-like 4 isoform X5

UniProtKB/TrEMBL

A0A8I5Y0M9, A6H9N0

Related

ENSRNOP00000076696.1

Conserved Domains (4) summary

sd00039
Location:548 → 583

7WD40; WD40 repeat [structural motif]

pfam03451
Location:135 → 206

HELP; HELP motif

cd21950
Location:6 → 64

TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4

cl29593
Location:412 → 773

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_039112151.2 → XP_038968079.1 echinoderm microtubule-associated protein-like 4 isoform X4

UniProtKB/TrEMBL

A6H9N0

Conserved Domains (4) summary

sd00039
Location:580 → 615

7WD40; WD40 repeat [structural motif]

pfam03451
Location:167 → 238

HELP; HELP motif

cd21950
Location:6 → 64

TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4

cl29593
Location:444 → 805

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_039112150.2 → XP_038968078.1 echinoderm microtubule-associated protein-like 4 isoform X3

UniProtKB/TrEMBL

A6H9N0, F1LT71

Related

ENSRNOP00000050319.4

Conserved Domains (4) summary

sd00039
Location:591 → 626

7WD40; WD40 repeat [structural motif]

pfam03451
Location:178 → 249

HELP; HELP motif

cd21950
Location:6 → 64

TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4

cl29593
Location:455 → 816

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_039112149.2 → XP_038968077.1 echinoderm microtubule-associated protein-like 4 isoform X2

UniProtKB/TrEMBL

A0A8I6A8G5, A0A8I6ALM1

Related

ENSRNOP00000087686.1

Conserved Domains (4) summary

sd00039
Location:638 → 673

7WD40; WD40 repeat [structural motif]

pfam03451
Location:225 → 296

HELP; HELP motif

cd21950
Location:6 → 64

TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4

cl29593
Location:502 → 863

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_039112148.2 → XP_038968076.1 echinoderm microtubule-associated protein-like 4 isoform X1

UniProtKB/TrEMBL

A0A0G2K2Z0, A0A8I6ALM1

Related

ENSRNOP00000072435.2

Conserved Domains (4) summary

sd00039
Location:649 → 684

7WD40; WD40 repeat [structural motif]

pfam03451
Location:236 → 307

HELP; HELP motif

cd21950
Location:6 → 64

TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4

cl29593
Location:513 → 874

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_039112154.2 → XP_038968082.1 echinoderm microtubule-associated protein-like 4 isoform X7

Conserved Domains (2) summary

sd00039
Location:315 → 350

7WD40; WD40 repeat [structural motif]

cl29593
Location:179 → 540

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...