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    DPP10 dipeptidyl peptidase like 10 [ Homo sapiens (human) ]

    Gene ID: 57628, updated on 3-Apr-2024

    Summary

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    Official Symbol
    DPP10provided by HGNC
    Official Full Name
    dipeptidyl peptidase like 10provided by HGNC
    Primary source
    HGNC:HGNC:20823
    See related
    Ensembl:ENSG00000175497 MIM:608209; AllianceGenome:HGNC:20823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DPL2; DPPY; DPRP3; DPRP-3
    Summary
    This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 7.5), adrenal (RPKM 2.9) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    2q14.1
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (114442641..115845780)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (114868138..116270550)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (115200218..116603356)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124906175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:115170872-115171372 Neighboring gene uncharacterized LOC124907877 Neighboring gene RNA, U2 small nuclear 41, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:115312469-115312655 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:115409386-115410190 Neighboring gene NANOG hESC enhancer GRCh37_chr2:115527347-115527874 Neighboring gene NANOG hESC enhancer GRCh37_chr2:115578660-115579193 Neighboring gene DPP10 antisense RNA 3 Neighboring gene uncharacterized LOC105373575 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:115843289-115844136 Neighboring gene uncharacterized LOC105373574 Neighboring gene uncharacterized LOC107985937 Neighboring gene DPP10 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:116185039-116185693 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:116232976-116233161 Neighboring gene ribosomal protein SA pseudogene 23 Neighboring gene uncharacterized LOC105373572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:116851897-116852396 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:116900117-116900937 Neighboring gene uncharacterized LOC105373576 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:117248055-117249254 Neighboring gene MT-CYB pseudogene 39

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Contribution of dipeptidyl peptidase 10 to airway dysfunction in patients with NSAID-exacerbated respiratory disease. Sim S, et al. Clin Exp Allergy, 2022 Jan. PMID 34431147
    2. DPP10 is a new regulator of Nav1.5 channels in human heart. Belau F, et al. Int J Cardiol, 2019 Jun 1. PMID 30638748
    3. Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association. Xu J, et al. Am J Respir Crit Care Med, 2019 Mar 1. PMID 30199657, Free PMC Article
    4. Use of clinical chromosomal microarray in Chinese patients with autism spectrum disorder-implications of a copy number variation involving DPP10. Mak ASL, et al. Mol Autism, 2017. PMID 28670437, Free PMC Article
    5. Dipeptidyl-peptidase 10 as a genetic biomarker for the aspirin-exacerbated respiratory disease phenotype. Kim SH, et al. Ann Allergy Asthma Immunol, 2015 Mar. PMID 25592153

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy.
      Title: Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy.
    2. Contribution of dipeptidyl peptidase 10 to airway dysfunction in patients with NSAID-exacerbated respiratory disease.
      Title: Contribution of dipeptidyl peptidase 10 to airway dysfunction in patients with NSAID-exacerbated respiratory disease.
    3. increased ventricular DPP10 expression in heart failure might promote arrhythmias by decreasing peak Na(+) current, while increasing window Na(+) current and channel re-openings due to accelerated recovery from inactivation
      Title: DPP10 is a new regulator of Nav1.5 channels in human heart.
    4. SNP rs11693320 associated with pulmonary function when incorporating an interaction with docosahexaenoic acid
      Title: Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association.
    5. These results show that a Dpp10 point mutation leads to increased airway responsiveness following allergen challenge.
      Title: Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma.
    6. The DPP10 duplication is likely a benign CNV polymorphism enriched in Southern Chinese with a population frequency of ~1%.
      Title: Use of clinical chromosomal microarray in Chinese patients with autism spectrum disorder-implications of a copy number variation involving DPP10.
    7. The stoichiometry of the Kv4.2-DPP10 complex was variable depending on the relative expression level of each subunit, with a preference for 4:2 stoichiometry
      Title: Kv4.2 and accessory dipeptidyl peptidase-like protein 10 (DPP10) subunit preferentially form a 4:2 (Kv4.2:DPP10) channel complex.
    8. the interaction of DPP10a, expressed in human atrium, with Kv4.3 channels generates a sustained current component of Ito, which may affect late repolarization phase of atrial action potentials.
      Title: Interaction of DPP10a with Kv4.3 channel complex results in a sustained current component of human transient outward current Ito.
    9. study suggests a genetic contribution of DPP10 rs17048175 in eosinophilic inflammation induction in the airways and to aspirin-exacerbated respiratory disease susceptibility
      Title: Dipeptidyl-peptidase 10 as a genetic biomarker for the aspirin-exacerbated respiratory disease phenotype.
    10. Our results suggest that DPP10(789) is involved in the pathology of AD and other neurodegenerative diseases.
      Title: Dipeptidyl peptidase 10 (DPP10(789)): a voltage gated potassium channel associated protein is abnormally expressed in Alzheimer's and other neurodegenerative diseases.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog
    Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables dipeptidyl-peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inactive dipeptidyl peptidase 10
    Names
    DPP X
    dipeptidyl peptidase 10
    dipeptidyl peptidase IV-related protein 3
    dipeptidyl peptidase X
    dipeptidyl peptidase-like protein 2
    dipeptidyl-peptidase 10 (inactive)
    dipeptidyl-peptidase 10 (non-functional)

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004360.5 → NP_001004360.3  inactive dipeptidyl peptidase 10 isoform short

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 3. The resulting isoform (short, also referred to as DPL2-s and d) has a shorter and distinct N-terminus when compared to isoform c.
      Source sequence(s)
      AC016721, AC017040, AC066593, AC067947, AC105422
      Consensus CDS
      CCDS33278.1
      UniProtKB/TrEMBL
      Q0GLB7
      Related
      ENSP00000309066.8, ENST00000310323.12
      Conserved Domains (2) summary
      pfam00326
      Location:573 → 775
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:126 → 492
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    2. NM_001178034.1 → NP_001171505.1  inactive dipeptidyl peptidase 10 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC016721, AC066593, DQ857322
      Consensus CDS
      CCDS54388.1
      UniProtKB/TrEMBL
      Q0GLB7
      Related
      ENSP00000376855.2, ENST00000393147.6
      Conserved Domains (2) summary
      pfam00326
      Location:584 → 786
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:137 → 503
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    3. NM_001178036.3 → NP_001171507.2  inactive dipeptidyl peptidase 10 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate 5' exon, as compared to variant 3. The resulting isoform (a) has a shorter and distinct N-terminus when compared to isoform c.
      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
      Consensus CDS
      CCDS54389.1
      UniProtKB/TrEMBL
      Q0GLB7
      Related
      ENSP00000387038.1, ENST00000409163.5
      Conserved Domains (2) summary
      pfam00326
      Location:530 → 732
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:83 → 449
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    4. NM_001178037.3 → NP_001171508.2  inactive dipeptidyl peptidase 10 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate 5' exon, as compared to variant 3. The resulting isoform (b) has a shorter and distinct N-terminus when compared to isoform c.
      Source sequence(s)
      AC016721, AC017040, AC067947, AC093610, AC105422
      UniProtKB/TrEMBL
      Q0GLB9
      Conserved Domains (2) summary
      pfam00326
      Location:576 → 778
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:129 → 495
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    5. NM_001321905.3 → NP_001308834.2  inactive dipeptidyl peptidase 10 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC012071, AC016721, AC017040, AC067947, AC105422
      UniProtKB/TrEMBL
      B2RCJ8
      Conserved Domains (2) summary
      pfam00326
      Location:597 → 799
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:150 → 516
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    6. NM_001321906.2 → NP_001308835.2  inactive dipeptidyl peptidase 10 isoform short

      Status: VALIDATED

      Source sequence(s)
      AC016721, AC066593, BM974067, DQ857322
      Consensus CDS
      CCDS33278.1
      UniProtKB/TrEMBL
      Q0GLB7
      Conserved Domains (2) summary
      pfam00326
      Location:573 → 775
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:126 → 492
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    7. NM_001321907.3 → NP_001308836.2  inactive dipeptidyl peptidase 10 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
      UniProtKB/TrEMBL
      B2RCJ8
      Conserved Domains (2) summary
      pfam00326
      Location:567 → 769
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:133 → 486
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    8. NM_001321908.3 → NP_001308837.2  inactive dipeptidyl peptidase 10 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
      UniProtKB/TrEMBL
      Q0GLB7
      Conserved Domains (2) summary
      pfam00326
      Location:550 → 752
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:103 → 469
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    9. NM_001321909.3 → NP_001308838.2  inactive dipeptidyl peptidase 10 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC016721, AC017040, AC066593, AC067947, AC105422
      UniProtKB/TrEMBL
      Q0GLB7
      Conserved Domains (2) summary
      pfam00326
      Location:541 → 743
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:94 → 460
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    10. NM_001321910.3 → NP_001308839.2  inactive dipeptidyl peptidase 10 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC012071, AC016721, AC017040, AC067947, AC105422
      Consensus CDS
      CCDS54389.1
      UniProtKB/TrEMBL
      Q0GLB7
      Conserved Domains (2) summary
      pfam00326
      Location:530 → 732
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:83 → 449
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    11. NM_001321911.3 → NP_001308840.2  inactive dipeptidyl peptidase 10 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
      Consensus CDS
      CCDS54389.1
      UniProtKB/TrEMBL
      Q0GLB7
      Conserved Domains (2) summary
      pfam00326
      Location:530 → 732
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:83 → 449
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    12. NM_001321912.3 → NP_001308841.2  inactive dipeptidyl peptidase 10 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
      UniProtKB/TrEMBL
      Q0GLB7
      Conserved Domains (2) summary
      pfam00930
      Location:83 → 449
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:530 → 677
      Abhydrolase; alpha/beta hydrolases

    13. NM_001321913.3 → NP_001308842.2  inactive dipeptidyl peptidase 10 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
      Conserved Domains (2) summary
      pfam00326
      Location:326 → 528
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:1 → 245
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    14. NM_001321914.2 → NP_001308843.2  inactive dipeptidyl peptidase 10 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC016721, AC066593, BM974067, DQ857322
      Conserved Domains (2) summary
      pfam00326
      Location:326 → 528
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:1 → 245
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    15. NM_001399849.1 → NP_001386778.1  inactive dipeptidyl peptidase 10 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC093610, AC105422
      Consensus CDS
      CCDS54389.1

    16. NM_001399850.1 → NP_001386779.1  inactive dipeptidyl peptidase 10 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC016721, AC017040, AC066593, AC067947, AC105422

    17. NM_001399851.1 → NP_001386780.1  inactive dipeptidyl peptidase 10 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC016721, AC017040, AC066593, AC067947, AC105422

    18. NM_020868.6 → NP_065919.3  inactive dipeptidyl peptidase 10 isoform long

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has an alternate 5' exon, as compared to variant 3. The resulting isoform (long, also referred to as DPL2-l) is slightly shorter and has a distinct N-terminus when compared to isoform c.
      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
      Consensus CDS
      CCDS46400.1
      UniProtKB/Swiss-Prot
      A8K1Q2, J3KPP2, J3KQ46, Q0GLB8, Q53QT3, Q53S86, Q53SL8, Q53SS4, Q6TTV4, Q86YR9, Q8N608, Q9P236
      UniProtKB/TrEMBL
      B2RCJ8
      Related
      ENSP00000386565.1, ENST00000410059.6
      Conserved Domains (2) summary
      pfam00326
      Location:580 → 782
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:133 → 499
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      114442641..115845780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445202.1 → XP_047301158.1  inactive dipeptidyl peptidase 10 isoform X1

    2. XM_047445203.1 → XP_047301159.1  inactive dipeptidyl peptidase 10 isoform X2

    3. XM_047445207.1 → XP_047301163.1  inactive dipeptidyl peptidase 10 isoform X4

    4. XM_047445205.1 → XP_047301161.1  inactive dipeptidyl peptidase 10 isoform X4

    5. XM_017004566.2 → XP_016860055.1  inactive dipeptidyl peptidase 10 isoform X3

      UniProtKB/TrEMBL
      Q0GLB7

    6. XM_047445204.1 → XP_047301160.1  inactive dipeptidyl peptidase 10 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      114868138..116270550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343190.1 → XP_054199165.1  inactive dipeptidyl peptidase 10 isoform X1

    2. XM_054343191.1 → XP_054199166.1  inactive dipeptidyl peptidase 10 isoform X2

    3. XM_054343193.1 → XP_054199168.1  inactive dipeptidyl peptidase 10 isoform X5

    4. XM_054343196.1 → XP_054199171.1  inactive dipeptidyl peptidase 10 isoform X4

    5. XM_054343195.1 → XP_054199170.1  inactive dipeptidyl peptidase 10 isoform X4

    6. XM_054343192.1 → XP_054199167.1  inactive dipeptidyl peptidase 10 isoform X3

    7. XM_054343194.1 → XP_054199169.1  inactive dipeptidyl peptidase 10 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N608.2 GenPept UniProtKB/Swiss-Prot:Q8N608

    Gene LinkOut

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