ACVRL1 activin A receptor like type 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: ACVRL1provided by VGNC
Official Full Name: activin A receptor like type 1provided by VGNC
Primary source: VGNC:VGNC:37566
See related: Ensembl:ENSCAFG00845027472
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 27

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	27	NC_051831.1 (3072148..3086549, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	27	NC_006609.4 (43166746..43181176)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	27	NC_049248.1 (43565141..43579587)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	27	NC_049287.1 (3088717..3103128, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	27	NC_049768.1 (3075021..3089444, complement)

Chromosome 27 - NC_051831.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

D12S2190 (e-PCR)
- UniSTS:474534

G64249 (e-PCR)
- UniSTS:166635

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables SMAD binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transforming growth factor beta receptor activity, type I	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in dorsal/ventral pattern formation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in heart development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of BMP receptor complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase receptor R3

XP_013964123.2

EC 2.7.11.30

XP_022266779.2

EC 2.7.11.30

XP_038294058.1

EC 2.7.11.30

XP_038294059.1

EC 2.7.11.30

XP_038368752.1

EC 2.7.11.30

XP_038368753.1

EC 2.7.11.30

XP_038433645.1

EC 2.7.11.30

XP_038433646.1

EC 2.7.11.30

XP_038496513.1

EC 2.7.11.30

XP_038496514.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051831.1 Reference ROS_Cfam_1.0

Range

3072148..3086549 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038438131.1 → XP_038294059.1 serine/threonine-protein kinase receptor R3 isoform X2

UniProtKB/TrEMBL

A0A7I8AUV5, A0A7I8AVG8, A0A8C0JIT4, A0A8P0SR48

Related

ENSCAFP00845038005.1, ENSCAFT00845048446.1

Conserved Domains (2) summary

cd14142
Location:197 → 494

STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

pfam08515
Location:174 → 201

TGF_beta_GS; Transforming growth factor beta type I GS-motif
XM_038438130.1 → XP_038294058.1 serine/threonine-protein kinase receptor R3 isoform X1

UniProtKB/TrEMBL

A0A7I8AVG8

Conserved Domains (2) summary

cd14142
Location:216 → 513

STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

pfam08515
Location:193 → 220

TGF_beta_GS; Transforming growth factor beta type I GS-motif

Alternate UMICH_Zoey_3.1

Genomic

NC_049287.1 Alternate UMICH_Zoey_3.1

Range

3088717..3103128 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038512825.1 → XP_038368753.1 serine/threonine-protein kinase receptor R3 isoform X2

Conserved Domains (2) summary

cd14142
Location:197 → 494

STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

pfam08515
Location:174 → 201

TGF_beta_GS; Transforming growth factor beta type I GS-motif
XM_038512824.1 → XP_038368752.1 serine/threonine-protein kinase receptor R3 isoform X1

Conserved Domains (2) summary

cd14142
Location:216 → 513

STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

pfam08515
Location:193 → 220

TGF_beta_GS; Transforming growth factor beta type I GS-motif

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049768.1 Alternate UNSW_CanFamBas_1.0

Range

3075021..3089444 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038640586.1 → XP_038496514.1 serine/threonine-protein kinase receptor R3 isoform X2

Conserved Domains (2) summary

cd14142
Location:197 → 494

STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

pfam08515
Location:174 → 201

TGF_beta_GS; Transforming growth factor beta type I GS-motif
XM_038640585.1 → XP_038496513.1 serine/threonine-protein kinase receptor R3 isoform X1

Conserved Domains (2) summary

cd14142
Location:216 → 513

STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

pfam08515
Location:193 → 220

TGF_beta_GS; Transforming growth factor beta type I GS-motif

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049248.1 Alternate UU_Cfam_GSD_1.0

Range

43565141..43579587

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038577718.1 → XP_038433646.1 serine/threonine-protein kinase receptor R3 isoform X2

UniProtKB/TrEMBL

A0A7I8AUV5, A0A7I8AVG8, A0A8C0JIT4, A0A8P0SR48

Conserved Domains (2) summary

cd14142
Location:197 → 494

STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

pfam08515
Location:174 → 201

TGF_beta_GS; Transforming growth factor beta type I GS-motif
XM_038577717.1 → XP_038433645.1 serine/threonine-protein kinase receptor R3 isoform X1

UniProtKB/TrEMBL

A0A7I8AVG8

Conserved Domains (2) summary

cd14142
Location:216 → 513

STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

pfam08515
Location:193 → 220

TGF_beta_GS; Transforming growth factor beta type I GS-motif

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

43166746..43181176

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_014108648.3 → XP_013964123.2 serine/threonine-protein kinase receptor R3 isoform X2

UniProtKB/TrEMBL

A0A7I8AUV5, A0A7I8AVG8, A0A8C0JIT4, A0A8P0SR48

Conserved Domains (2) summary

cd14142
Location:197 → 494

STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

pfam08515
Location:174 → 201

TGF_beta_GS; Transforming growth factor beta type I GS-motif
XM_022411071.2 → XP_022266779.2 serine/threonine-protein kinase receptor R3 isoform X1

UniProtKB/TrEMBL

A0A7I8AVG8

Conserved Domains (2) summary

cd14142
Location:216 → 513

STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

pfam08515
Location:193 → 220

TGF_beta_GS; Transforming growth factor beta type I GS-motif