Kif2c kinesin family member 2C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kif2cprovided by RGD
Official Full Name: kinesin family member 2Cprovided by RGD
Primary source: RGD:620239
See related: Ensembl:ENSRNOG00000019100 AllianceGenome:RGD:620239
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: KRP2; MCAK
Summary: Predicted to enable ATP hydrolysis activity; microtubule motor activity; and microtubule plus-end binding activity. Predicted to be involved in several processes, including attachment of mitotic spindle microtubules to kinetochore; microtubule cytoskeleton organization; and regulation of chromosome segregation. Predicted to be located in kinetochore and microtubule plus-end. Predicted to be part of kinesin complex. Predicted to be active in centrosome; microtubule; and spindle. Predicted to colocalize with cytoplasmic microtubule. Orthologous to human KIF2C (kinesin family member 2C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 242.3), Thymus (RPKM 120.0) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (135873925..135899267, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (130637347..130662680, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (136027923..136053268, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141804 (e-PCR)
- UniSTS:223796

UniSTS:237556 (e-PCR)
- UniSTS:237556

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables microtubule plus-end binding	IEA Inferred from Electronic Annotation more info
enables microtubule plus-end binding	ISO Inferred from Sequence Orthology more info
enables microtubule plus-end binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore	IEA Inferred from Electronic Annotation more info
involved_in attachment of mitotic spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in attachment of mitotic spindle microtubules to kinetochore	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in establishment or maintenance of microtubule cytoskeleton polarity	IEA Inferred from Electronic Annotation more info
involved_in establishment or maintenance of microtubule cytoskeleton polarity	ISO Inferred from Sequence Orthology more info
involved_in metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in metaphase chromosome alignment	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule depolymerization	IEA Inferred from Electronic Annotation more info
involved_in microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynaptic cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in regulation of chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic microtubule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in microtubule plus-end	IEA Inferred from Electronic Annotation more info
located_in microtubule plus-end	ISO Inferred from Sequence Orthology more info
located_in microtubule plus-end	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in spindle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kinesin-like protein KIF2C

Names: kinesin-related protein 2; mitotic centromere-associated kinesin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085369.2 → NP_001078838.1 kinesin-like protein KIF2C isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

FN805204, JAXUCZ010000005

UniProtKB/Swiss-Prot

Q62909

Conserved Domains (2) summary

cd01367
Location:254 → 582

KISc_KIF2_like; Kinesin motor domain, KIF2-like group

pfam00225
Location:260 → 583

Kinesin; Kinesin motor domain
NM_001305429.1 → NP_001292358.1 kinesin-like protein KIF2C isoform 3

See identical proteins and their annotated locations for NP_001292358.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1, but has an additional internal amino acid.

Source sequence(s)

FN805204, JAXUCZ010000005

UniProtKB/Swiss-Prot

Q62909

UniProtKB/TrEMBL

A6JZD0

Conserved Domains (2) summary

cd01367
Location:204 → 532

KISc_KIF2_like; Kinesin motor domain, KIF2-like group

pfam00225
Location:210 → 533

Kinesin; Kinesin motor domain
NM_134472.4 → NP_608302.2 kinesin-like protein KIF2C isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

FN805204, JAXUCZ010000005

UniProtKB/Swiss-Prot

Q62909

Conserved Domains (2) summary

cd01367
Location:203 → 531

KISc_KIF2_like; Kinesin motor domain, KIF2-like group

pfam00225
Location:209 → 532

Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

135873925..135899267 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238632.5 → XP_006238694.1 kinesin-like protein KIF2C isoform X1

UniProtKB/Swiss-Prot

Q62909

UniProtKB/TrEMBL

D3ZQG8

Related

ENSRNOP00000025903.5

Conserved Domains (2) summary

cd01367
Location:255 → 583

KISc_KIF2_like; Kinesin motor domain, KIF2-like group

pfam00225
Location:261 → 584

Kinesin; Kinesin motor domain
XM_063287143.1 → XP_063143213.1 kinesin-like protein KIF2C isoform X5
XM_006238633.4 → XP_006238695.1 kinesin-like protein KIF2C isoform X2

UniProtKB/Swiss-Prot

Q62909

UniProtKB/TrEMBL

F1M457

Conserved Domains (1) summary

cd01367
Location:207 → 535

KISc_KIF2_like; Kinesin motor domain, KIF2-like group
XM_063287141.1 → XP_063143211.1 kinesin-like protein KIF2C isoform X4

UniProtKB/TrEMBL

A6JZD0
XM_063287142.1 → XP_063143212.1 kinesin-like protein KIF2C isoform X5
XM_063287140.1 → XP_063143210.1 kinesin-like protein KIF2C isoform X4

UniProtKB/TrEMBL

A6JZD0
XM_017593141.3 → XP_017448630.1 kinesin-like protein KIF2C isoform X2

UniProtKB/Swiss-Prot

Q62909

UniProtKB/TrEMBL

F1M457

Related

ENSRNOP00000061433.4

Conserved Domains (1) summary

cd01367
Location:207 → 535

KISc_KIF2_like; Kinesin motor domain, KIF2-like group
XM_063287139.1 → XP_063143209.1 kinesin-like protein KIF2C isoform X3
XM_039109239.2 → XP_038965167.1 kinesin-like protein KIF2C isoform X2

UniProtKB/Swiss-Prot

Q62909

UniProtKB/TrEMBL

F1M457

Conserved Domains (1) summary

cd01367
Location:207 → 535

KISc_KIF2_like; Kinesin motor domain, KIF2-like group