Dcaf12l1 DDB1 and CUL4 associated factor 12-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dcaf12l1provided by RGD
Official Full Name: DDB1 and CUL4 associated factor 12-like 1provided by RGD
Primary source: RGD:1563873
See related: Ensembl:ENSRNOG00000023458 AllianceGenome:RGD:1563873
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dcaf12; Wdr40b; RGD1563873
Summary: Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Orthologous to human DCAF12L1 (DDB1 and CUL4 associated factor 12 like 1) and DCAF12L2 (DDB1 and CUL4 associated factor 12 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 71.4), Adrenal (RPKM 36.0) and 3 other tissues See more
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Genomic context

Location:: Xq35

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (128572969..128576588, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (123695286..123698905, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (131340045..131344038, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: DDB1- and CUL4-associated factor 12-like protein 1

Names: DDB1 and CUL4 associated factor 12; WD repeat domain 40B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107941.1 → NP_001101411.1 DDB1- and CUL4-associated factor 12-like protein 1

See identical proteins and their annotated locations for NP_001101411.1

Status: PROVISIONAL

Source sequence(s)

CH473991

UniProtKB/TrEMBL

A6JMN3, D4ABX0

Related

ENSRNOP00000038146.3, ENSRNOT00000038653.5

Conserved Domains (3) summary

COG2319
Location:190 → 428

WD40; WD40 repeat [General function prediction only]

sd00039
Location:138 → 180

7WD40; WD40 repeat [structural motif]

cl02567
Location:133 → 327

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...