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    Arhgap23 Rho GTPase activating protein 23 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303501, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Arhgap23provided by RGD
    Official Full Name
    Rho GTPase activating protein 23provided by RGD
    Primary source
    RGD:1309742
    See related
    Ensembl:ENSRNOG00000022771 AllianceGenome:RGD:1309742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arhgap23l
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of catalytic activity and signal transduction. Orthologous to human ARHGAP23 (Rho GTPase activating protein 23). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 48.7), Brain (RPKM 39.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgap23 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (82891021..82993230)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82437578..82496846)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85387219..85445805)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene dual specificity protein phosphatase 26 pseudogene Neighboring gene suppressor of cytokine signaling 7 Neighboring gene uncharacterized LOC134480864 Neighboring gene SRC kinase signaling inhibitor 1 Neighboring gene uncharacterized LOC102548331 Neighboring gene uncharacterized LOC134480715

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    2. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 23
    Names
    Rho GTPase activating protein 23 like
    pulmonary surfactant-associated protein D-like
    translation initiation factor IF-2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428749.1 → NP_001415678.1  rho GTPase-activating protein 23

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      F1M2D4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      82891021..82993230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270144.1 → XP_063126214.1  rho GTPase-activating protein 23 isoform X6

    2. XM_063270145.1 → XP_063126215.1  rho GTPase-activating protein 23 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AMV0

    3. XM_063270143.1 → XP_063126213.1  rho GTPase-activating protein 23 isoform X5

    4. XM_063270146.1 → XP_063126216.1  rho GTPase-activating protein 23 isoform X10

      UniProtKB/TrEMBL
      F1M2D4

    5. XM_017597699.3 → XP_017453188.1  rho GTPase-activating protein 23 isoform X3

      Conserved Domains (4) summary
      cd00992
      Location:4 → 57
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:754 → 949
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:542 → 662
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:541 → 660
      PH; PH domain

    6. XM_006247437.3 → XP_006247499.1  rho GTPase-activating protein 23 isoform X1

      Conserved Domains (4) summary
      cd00992
      Location:4 → 57
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:806 → 1001
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:594 → 714
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:593 → 712
      PH; PH domain

    7. XM_039087723.2 → XP_038943651.1  rho GTPase-activating protein 23 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AA04
      Related
      ENSRNOP00000089331.1
      Conserved Domains (4) summary
      PHA03247
      Location:89 → 481
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4 → 57
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:806 → 1001
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:594 → 714
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

    8. XM_008768199.4 → XP_008766421.1  rho GTPase-activating protein 23 isoform X4

      Conserved Domains (3) summary
      cd00992
      Location:4 → 57
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:723 → 918
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cl17171
      Location:498 → 631
      PH-like; Pleckstrin homology-like domain

    9. XM_039087721.2 → XP_038943649.1  rho GTPase-activating protein 23 isoform X8

      Conserved Domains (4) summary
      PHA03247
      Location:89 → 481
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4 → 57
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:806 → 1001
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:594 → 714
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

    10. XM_039087722.2 → XP_038943650.1  rho GTPase-activating protein 23 isoform X8

      Conserved Domains (4) summary
      PHA03247
      Location:89 → 481
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4 → 57
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:806 → 1001
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:594 → 714
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

    11. XM_017597700.3 → XP_017453189.1  rho GTPase-activating protein 23 isoform X9

      Conserved Domains (3) summary
      cd04395
      Location:694 → 889
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:482 → 602
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:481 → 600
      PH; PH domain
    Nucleotide Protein Strain
    Heading Accession and Version

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