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    Mga MAX dimerization protein MGA [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499874, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Mgaprovided by RGD
    Official Full Name
    MAX dimerization protein MGAprovided by RGD
    Primary source
    RGD:1561597
    See related
    Ensembl:ENSRNOG00000006378 AllianceGenome:RGD:1561597
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561597
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be part of MLL1 complex and transcription regulator complex. Orthologous to human MGA (MAX dimerization protein MGA). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 210.4), Spleen (RPKM 182.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mga in Genome Data Viewer
    Location:
    3q35
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (127300558..127396694)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (106851216..106942908)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (111669645..111760822)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene TYRO3 protein tyrosine kinase Neighboring gene GABA type A receptor-associated protein, pseudogene 2 Neighboring gene mitogen activated protein kinase binding protein 1 Neighboring gene phospholipase A2 group IVB Neighboring gene jumonji domain containing 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif. Hurlin PJ, et al. EMBO J, 1999 Dec 15. PMID 10601024, Free PMC Article
    2. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Dou Y, et al. Cell, 2005 Jun 17. PMID 15960975
    3. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MLL1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MAX gene-associated protein
    Names
    MAX gene associated
    MGA, MAX dimerization protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      127300558..127396694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762120.4 → XP_008760342.1  MAX gene-associated protein isoform X1

      See identical proteins and their annotated locations for XP_008760342.1

      UniProtKB/TrEMBL
      A0A8I6AGZ4, D3ZJB5
      Conserved Domains (5) summary
      pfam05109
      Location:1519 → 1828
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd18911
      Location:2454 → 2518
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins
      pfam03154
      Location:1692 → 2024
      Atrophin-1; Atrophin-1 family
      pfam16059
      Location:1040 → 1081
      DUF4801; Domain of unknown function (DUF4801)
      cd20195
      Location:75 → 260
      T-box_MGA-like; DNA-binding domain of MAX gene-associated protein and related T-box proteins

    2. XM_063284962.1 → XP_063141032.1  MAX gene-associated protein isoform X2

      UniProtKB/TrEMBL
      D3ZJB5

    3. XM_006234799.5 → XP_006234861.1  MAX gene-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006234861.1

      UniProtKB/TrEMBL
      A0A8I6AGZ4, D3ZJB5
      Related
      ENSRNOP00000008528.6
      Conserved Domains (5) summary
      pfam05109
      Location:1519 → 1828
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd18911
      Location:2454 → 2518
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins
      pfam03154
      Location:1692 → 2024
      Atrophin-1; Atrophin-1 family
      pfam16059
      Location:1040 → 1081
      DUF4801; Domain of unknown function (DUF4801)
      cd20195
      Location:75 → 260
      T-box_MGA-like; DNA-binding domain of MAX gene-associated protein and related T-box proteins

    4. XM_063284964.1 → XP_063141034.1  MAX gene-associated protein isoform X3

      UniProtKB/TrEMBL
      D3ZJB5, D3ZP58

    5. XM_006234798.4 → XP_006234860.1  MAX gene-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006234860.1

      UniProtKB/TrEMBL
      A0A8I6AGZ4, D3ZJB5
      Related
      ENSRNOP00000092652.1
      Conserved Domains (5) summary
      pfam05109
      Location:1519 → 1828
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd18911
      Location:2454 → 2518
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins
      pfam03154
      Location:1692 → 2024
      Atrophin-1; Atrophin-1 family
      pfam16059
      Location:1040 → 1081
      DUF4801; Domain of unknown function (DUF4801)
      cd20195
      Location:75 → 260
      T-box_MGA-like; DNA-binding domain of MAX gene-associated protein and related T-box proteins

    6. XM_063284963.1 → XP_063141033.1  MAX gene-associated protein isoform X3

      UniProtKB/TrEMBL
      D3ZJB5, D3ZP58

    7. XM_006234797.5 → XP_006234859.1  MAX gene-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006234859.1

      UniProtKB/TrEMBL
      A0A8I6AGZ4, D3ZJB5
      Conserved Domains (5) summary
      pfam05109
      Location:1519 → 1828
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd18911
      Location:2454 → 2518
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins
      pfam03154
      Location:1692 → 2024
      Atrophin-1; Atrophin-1 family
      pfam16059
      Location:1040 → 1081
      DUF4801; Domain of unknown function (DUF4801)
      cd20195
      Location:75 → 260
      T-box_MGA-like; DNA-binding domain of MAX gene-associated protein and related T-box proteins

    8. XM_006234800.5 → XP_006234862.1  MAX gene-associated protein isoform X3

      UniProtKB/TrEMBL
      D3ZJB5, D3ZP58
      Related
      ENSRNOP00000060519.2
      Conserved Domains (3) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:2405 → 2455
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:1040 → 1086
      DUF4801; Domain of unknown function (DUF4801)

    9. XM_039106505.2 → XP_038962433.1  MAX gene-associated protein isoform X4

      UniProtKB/TrEMBL
      D3ZJB5
      Conserved Domains (5) summary
      pfam05109
      Location:1409 → 1718
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd18911
      Location:2344 → 2408
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins
      pfam03154
      Location:1541 → 1914
      Atrophin-1; Atrophin-1 family
      pfam16059
      Location:1040 → 1081
      DUF4801; Domain of unknown function (DUF4801)
      cd20195
      Location:75 → 260
      T-box_MGA-like; DNA-binding domain of MAX gene-associated protein and related T-box proteins

    10. XM_039106506.2 → XP_038962434.1  MAX gene-associated protein isoform X5

      UniProtKB/TrEMBL
      D3ZJB5
      Conserved Domains (5) summary
      pfam05109
      Location:1361 → 1669
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd18911
      Location:2295 → 2359
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins
      pfam03154
      Location:1492 → 1865
      Atrophin-1; Atrophin-1 family
      pfam16059
      Location:1040 → 1081
      DUF4801; Domain of unknown function (DUF4801)
      cd20195
      Location:75 → 260
      T-box_MGA-like; DNA-binding domain of MAX gene-associated protein and related T-box proteins

    11. XM_039106503.2 → XP_038962431.1  MAX gene-associated protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6AGZ4, D3ZJB5
      Conserved Domains (5) summary
      pfam05109
      Location:1519 → 1828
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd18911
      Location:2454 → 2518
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins
      pfam03154
      Location:1692 → 2024
      Atrophin-1; Atrophin-1 family
      pfam16059
      Location:1040 → 1081
      DUF4801; Domain of unknown function (DUF4801)
      cd20195
      Location:75 → 260
      T-box_MGA-like; DNA-binding domain of MAX gene-associated protein and related T-box proteins

    12. XM_039106508.2 → XP_038962436.1  MAX gene-associated protein isoform X7

      Conserved Domains (2) summary
      pfam16059
      Location:1040 → 1081
      DUF4801; Domain of unknown function (DUF4801)
      cd20195
      Location:75 → 260
      T-box_MGA-like; DNA-binding domain of MAX gene-associated protein and related T-box proteins

    13. XM_039106509.2 → XP_038962437.1  MAX gene-associated protein isoform X8

      Conserved Domains (2) summary
      pfam16059
      Location:1040 → 1081
      DUF4801; Domain of unknown function (DUF4801)
      cd20195
      Location:75 → 260
      T-box_MGA-like; DNA-binding domain of MAX gene-associated protein and related T-box proteins

    14. XM_063284966.1 → XP_063141036.1  MAX gene-associated protein isoform X9

    15. XM_063284965.1 → XP_063141035.1  MAX gene-associated protein isoform X9

    16. XM_063284967.1 → XP_063141037.1  MAX gene-associated protein isoform X10

    17. XM_039106507.2 → XP_038962435.1  MAX gene-associated protein isoform X6

      Conserved Domains (3) summary
      pfam05109
      Location:34 → 343
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd18911
      Location:969 → 1033
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins
      pfam03154
      Location:219 → 539
      Atrophin-1; Atrophin-1 family
    Nucleotide Protein Strain
    Heading Accession and Version

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