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    Fbxo40 F-box protein 40 [ Mus musculus (house mouse) ]

    Gene ID: 207215, updated on 28-Apr-2024

    Summary

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    Official Symbol
    Fbxo40provided by MGI
    Official Full Name
    F-box protein 40provided by MGI
    Primary source
    MGI:MGI:2443753
    See related
    Ensembl:ENSMUSG00000047746 AllianceGenome:MGI:2443753
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1195; 9830003A13Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Acts upstream of or within muscle cell differentiation. Located in cytoplasm. Orthologous to human FBXO40 (F-box protein 40). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in heart adult (RPKM 22.5), mammary gland adult (RPKM 3.6) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 B3; 16 26.32 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (36783823..36811321, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (36963461..36990530, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930565N06 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:36884785-36885086 Neighboring gene STARR-seq mESC enhancer starr_40776 Neighboring gene golgin B1 Neighboring gene STARR-positive B cell enhancer ABC_E8632 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:36932162-36932315 Neighboring gene STARR-positive B cell enhancer ABC_E7446 Neighboring gene STARR-positive B cell enhancer ABC_E4169 Neighboring gene STARR-seq mESC enhancer starr_40777 Neighboring gene hematopoietic cell specific Lyn substrate 1 Neighboring gene STARR-seq mESC enhancer starr_40778 Neighboring gene STARR-positive B cell enhancer ABC_E8633 Neighboring gene STARR-positive B cell enhancer ABC_E950 Neighboring gene polymerase (DNA directed), theta Neighboring gene syntaxin binding protein 5-like Neighboring gene STARR-seq mESC enhancer starr_40780 Neighboring gene STARR-seq mESC enhancer starr_40781 Neighboring gene LIM and senescent cell antigen like domains 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy. Ye J, et al. Gene, 2007 Dec 1. PMID 17928169
    2. The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling. Shi J, et al. Dev Cell, 2011 Nov 15. PMID 22033112
    3. The chromatin regulator Brpf1 regulates embryo development and cell proliferation. You L, et al. J Biol Chem, 2015 May 1. PMID 25773539, Free PMC Article
    4. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Fbxo40 is muscle specific in expression and is upregulated during differentiation.
      Title: The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling.
    2. FBXO40 may function as a regulator involved in the postnatal myogenesis.
      Title: FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1195, MGC130416, MGC130417

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in muscle cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-box only protein 40

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037321.2 → NP_001032398.1  F-box only protein 40

      See identical proteins and their annotated locations for NP_001032398.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC154763
      Consensus CDS
      CCDS37337.1
      UniProtKB/Swiss-Prot
      P62932
      UniProtKB/TrEMBL
      Q3KN92, Q5DTZ7
      Related
      ENSMUSP00000110454.2, ENSMUST00000114806.2
      Conserved Domains (2) summary
      pfam15965
      Location:12 → 104
      zf-TRAF_2; TRAF-like zinc-finger
      pfam15966
      Location:575 → 683
      F-box_4

    2. NM_001358217.1 → NP_001345146.1  F-box only protein 40

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC154763
      Consensus CDS
      CCDS37337.1
      UniProtKB/Swiss-Prot
      P62932
      UniProtKB/TrEMBL
      Q3KN92, Q5DTZ7
      Related
      ENSMUSP00000075266.7, ENSMUST00000075869.13
      Conserved Domains (2) summary
      pfam15965
      Location:12 → 104
      zf-TRAF_2; TRAF-like zinc-finger
      pfam15966
      Location:575 → 683
      F-box_4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      36783823..36811321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521883.5 → XP_006521946.1  F-box only protein 40 isoform X2

      UniProtKB/TrEMBL
      Q5DTZ7
      Conserved Domains (2) summary
      pfam15965
      Location:1 → 57
      zf-TRAF_2; TRAF-like zinc-finger
      pfam15966
      Location:528 → 636
      F-box_4

    2. XM_006521882.4 → XP_006521945.1  F-box only protein 40 isoform X1

      See identical proteins and their annotated locations for XP_006521945.1

      UniProtKB/Swiss-Prot
      P62932
      UniProtKB/TrEMBL
      Q3KN92, Q5DTZ7
      Conserved Domains (2) summary
      pfam15965
      Location:12 → 104
      zf-TRAF_2; TRAF-like zinc-finger
      pfam15966
      Location:575 → 683
      F-box_4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62932.1 GenPept UniProtKB/Swiss-Prot:P62932

    Gene LinkOut

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