TBX5 T-box 5 [Gallus gallus (chicken)] - Gene

Summary

Symbol: TBX5provided by CGNC
Full Name: T-box 5provided by CGNC
Primary source: CGNC:6251
See related: Ensembl:ENSGALG00010000151
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	15	NC_052546.1 (12317331..12358320)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	15	NC_052587.1 (12329351..12370319)

Chromosome 15 - NC_052546.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutations Upstream of the TBX5 and PITX1 Transcription Factor Genes Are Associated with Feathered Legs in the Domestic Chicken.
Title: Mutations Upstream of the TBX5 and PITX1 Transcription Factor Genes Are Associated with Feathered Legs in the Domestic Chicken.
Parallel Genetic Origin of Foot Feathering in Birds.
Title: Parallel Genetic Origin of Foot Feathering in Birds.
Tbx5 and Tbx4 expression in forelimb and hindlimb, respectively, are not sufficient for limb outgrowth and that input from RA is required.
Title: RA Acts in a Coherent Feed-Forward Mechanism with Tbx5 to Control Limb Bud Induction and Initiation.
Forelimb-restricted expression of Tbx5 and ultimately forelimb formation is therefore achieved through co-option of two characteristics of Hox genes; their colinear expression along the body axis and the functional specificity of different paralogs.
Title: A combination of activation and repression by a colinear Hox code controls forelimb-restricted expression of Tbx5 and reveals Hox protein specificity.
Results show that in the chick retina the compartmentalized expression of retinoic acid metabolizing enzymes RALDH-1, RALDH-3 and CYP26A1 requires the spatially restricted expression of the transcription factors cVax/Vax2 and Tbx5
Title: Regulation of RALDH-1, RALDH-3 and CYP26A1 by transcription factors cVax/Vax2 and Tbx5 in the embryonic chick retina.
An evoluionarily conserved nuclear export signal faciltates localization of the Tbx5 transcription factor.
Title: An evolutionarily conserved nuclear export signal facilitates cytoplasmic localization of the Tbx5 transcription factor.
These studies provide in vivo significance of the LMP4/Tbx5 protein interaction, suggesting both nuclear and cytoplasmic roles for Tbx5.
Title: Differential regulation of Tbx5 protein expression and sub-cellular localization during heart development.
LMP4 acts as a repressor of Tbx5 activity.
Title: LMP4 regulates Tbx5 protein subcellular localization and activity.
Pax6 together with cVax and Tbx5 mediates dorsoventral patterning of the eye
Title: Pax6 interacts with cVax and Tbx5 to establish the dorsoventral boundary of the developing eye.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tbx5 (e-PCR), detects polymorphism
- UniSTS:528216

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cardiac left ventricle formation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell fate specification	IEA Inferred from Electronic Annotation more info	PubMed
involved_in pattern specification process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: T-box transcription factor TBX5

Names: T-box protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204173.1 → NP_989504.1 T-box transcription factor TBX5

See identical proteins and their annotated locations for NP_989504.1

Status: PROVISIONAL

Source sequence(s)

AF069396

UniProtKB/Swiss-Prot

O73719, Q9PWE8

UniProtKB/TrEMBL

A0A8V0X6Q8

Related

ENSGALP00010000153.1, ENSGALT00010000285.1

Conserved Domains (1) summary

cd00182
Location:53 → 241

TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052546.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

12317331..12358320

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015294831.4 → XP_015150317.1 T-box transcription factor TBX5 isoform X1

UniProtKB/TrEMBL

A0A8V0X6D1, A0A8V0X6Q8

Related

ENSGALP00010000155.1, ENSGALT00010000287.1

Conserved Domains (1) summary

cd00182
Location:69 → 257

TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...