U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cfp complement factor properdin [ Danio rerio (zebrafish) ]

    Gene ID: 556399, updated on 27-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cfpprovided by ZNC
    Official Full Name
    complement factor properdinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9247
    See related
    Ensembl:ENSDARG00000094451 AllianceGenome:ZFIN:ZDB-GENE-030131-9247
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fj10b08; ch:af064832; si:dkeyp-22b2.3
    Summary
    Acts upstream of or within immune response. Is expressed in several structures, including cardiovascular system; digestive system; eye; gonad; and neutrophil. Human ortholog(s) of this gene implicated in X-linked properdin deficiency. Orthologous to human CFP (complement factor properdin). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 8
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (23672245..23688505, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (23651013..23667293, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene transfer RNA phenylalanine (anticodon GAA) Neighboring gene transfer RNA arginine (anticodon ACG) Neighboring gene si:ch73-237c6.1 Neighboring gene peroxisome proliferator-activated receptor delta b

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Expression and functional analysis of properdin in zebrafish Danio rerio. Zhang Y, et al. Dev Comp Immunol, 2013 Jun. PMID 23416932
    2. Three isoforms of complement properdin factor P in trout: cloning, expression, gene organization and constrained modeling. Chondrou M, et al. Dev Comp Immunol, 2008. PMID 18638502
    3. A comparison of behavioral and reproductive parameters between wild-type, transgenic and mutant zebrafish: Could they all be considered the same "zebrafish" for reglementary assays on endocrine disruption? De Oliveira J, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2021 Jan. PMID 32877737
    4. Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling. Xiao Y, et al. Nat Neurosci, 2022 Mar. PMID 35241802, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    properdin; complement factor properdin
    Names
    zfp

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160126.1 → NP_001153598.1  properdin precursor

      See identical proteins and their annotated locations for NP_001153598.1

      Status: PROVISIONAL

      Source sequence(s)
      BX469917
      UniProtKB/TrEMBL
      A0A8M1NSW8, B0S697
      Related
      ENSDARP00000117151.1, ENSDART00000136865.3
      Conserved Domains (3) summary
      smart00209
      Location:127 → 179
      TSP1; Thrombospondin type 1 repeats
      pfam00090
      Location:72 → 120
      TSP_1; Thrombospondin type 1 domain
      cl15278
      Location:362 → 437
      TSP_1; Thrombospondin type 1 domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      23672245..23688505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167038.4 → XP_005167095.1  complement factor properdin isoform X1

      See identical proteins and their annotated locations for XP_005167095.1

      UniProtKB/TrEMBL
      A0A8M1NSW8, B0S697
      Conserved Domains (3) summary
      smart00209
      Location:127 → 179
      TSP1; Thrombospondin type 1 repeats
      pfam00090
      Location:72 → 120
      TSP_1; Thrombospondin type 1 domain
      cl15278
      Location:362 → 437
      TSP_1; Thrombospondin type 1 domain

    2. XM_017357340.2 → XP_017212829.1  complement factor properdin isoform X1

      UniProtKB/TrEMBL
      A0A8M1NSW8, B0S697
      Conserved Domains (3) summary
      smart00209
      Location:127 → 179
      TSP1; Thrombospondin type 1 repeats
      pfam00090
      Location:72 → 120
      TSP_1; Thrombospondin type 1 domain
      cl15278
      Location:362 → 437
      TSP_1; Thrombospondin type 1 domain

    3. XM_005167041.4 → XP_005167098.1  complement factor properdin isoform X1

      See identical proteins and their annotated locations for XP_005167098.1

      UniProtKB/TrEMBL
      A0A8M1NSW8, B0S697
      Conserved Domains (3) summary
      smart00209
      Location:127 → 179
      TSP1; Thrombospondin type 1 repeats
      pfam00090
      Location:72 → 120
      TSP_1; Thrombospondin type 1 domain
      cl15278
      Location:362 → 437
      TSP_1; Thrombospondin type 1 domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.