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    SLC22A25 solute carrier family 22 member 25 [ Homo sapiens (human) ]

    Gene ID: 387601, updated on 3-Apr-2024

    Summary

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    Official Symbol
    SLC22A25provided by HGNC
    Official Full Name
    solute carrier family 22 member 25provided by HGNC
    Primary source
    HGNC:HGNC:32935
    See related
    Ensembl:ENSG00000196600 MIM:610792; AllianceGenome:HGNC:32935
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UST6; HIMTP
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward liver (RPKM 2.7) See more
    Orthologs
    all
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    Genomic context

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    Location:
    11q12.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63158437..63243599, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63147661..63232786, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62925909..63011071, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene tubulin alpha pseudogene 7 Neighboring gene solute carrier family 22 member 24 Neighboring gene ribosomal protein L29 pseudogene 22 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:62969965-62970144 Neighboring gene uncharacterized LOC105369334 Neighboring gene cyclin D2 pseudogene 1 Neighboring gene solute carrier family 22 member 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of TNFSF13, SPATC1L, SLC22A25 and SALL4 as novel susceptibility loci for atrial fibrillation by an exome‑wide association study. Yamada Y, et al. Mol Med Rep, 2017 Nov. PMID 28849223, Free PMC Article
    2. Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney. Zaïr ZM, et al. Pharmacogenomics, 2008 May. PMID 18466105
    3. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. Eraly SA, et al. Physiol Genomics, 2004 Jun 17. PMID 15054140
    4. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Jacobsson JA, et al. Genomics, 2007 Nov. PMID 17714910
    5. Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. Xu XR, et al. Proc Natl Acad Sci U S A, 2001 Dec 18. PMID 11752456, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TNFSF13, SPATC1L, SLC22A25 and SALL4 may thus be novel susceptibility loci for atrial fibrillation in the Japanese population
      Title: Identification of TNFSF13, SPATC1L, SLC22A25 and SALL4 as novel susceptibility loci for atrial fibrillation by an exome‑wide association study.
    2. Review summarizes current knowledge on the functional and phenotypic consequences of genetic variation in intestinally, hepatically and renally expressed members of solute carrier family (SLC) member 25.
      Title: Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney.
    3. cloning of a novel human slc22 family member, UST6, expressed exclusively in liver in both embryo and adult, is reported [UST6]
      Title: Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC120420, MGI:2385316, MGI:2442750, MGI:2442751, MGI:3042283, MGI:3605624, MGI:3645714

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 22 member 25
    Names
    MGI:2442751, MGI:2385316, MGI:3042283, MGI:3645714, MGI:3605624, MGI:2442750
    organic anion transporter UST6
    putative UST1-like organic anion transporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394058.1 → NP_001380987.1  solute carrier family 22 member 25 isoform b

      Status: VALIDATED

      Source sequence(s)
      AP001880, AP003420
      UniProtKB/TrEMBL
      A4IF29
      Conserved Domains (2) summary
      TIGR00898
      Location:11 → 356
      2A0119; cation transport protein
      cl28910
      Location:109 → 280
      MFS; Major Facilitator Superfamily

    2. NM_001394059.1 → NP_001380988.1  solute carrier family 22 member 25 isoform b

      Status: VALIDATED

      Source sequence(s)
      AP001880, AP003420
      UniProtKB/TrEMBL
      A4IF29
      Conserved Domains (2) summary
      TIGR00898
      Location:11 → 356
      2A0119; cation transport protein
      cl28910
      Location:109 → 280
      MFS; Major Facilitator Superfamily

    3. NM_199352.6 → NP_955384.3  solute carrier family 22 member 25 isoform a

      See identical proteins and their annotated locations for NP_955384.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AP001880, AP003420
      Consensus CDS
      CCDS31592.1
      UniProtKB/Swiss-Prot
      A4FU27, Q6T423
      Related
      ENSP00000307443.6, ENST00000306494.11
      Conserved Domains (2) summary
      cd06174
      Location:151 → 516
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11 → 525
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      63158437..63243599 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426917.1 → XP_047282873.1  solute carrier family 22 member 25 isoform X1

      Related
      ENSP00000432242.1, ENST00000527057.5

    2. XM_017017695.2 → XP_016873184.1  solute carrier family 22 member 25 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      63147661..63232786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368730.1 → XP_054224705.1  solute carrier family 22 member 25 isoform X1

    2. XM_054368731.1 → XP_054224706.1  solute carrier family 22 member 25 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6T423.2 GenPept UniProtKB/Swiss-Prot:Q6T423

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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