OPRK1 opioid receptor kappa 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OPRK1provided by HGNC
Official Full Name: opioid receptor kappa 1provided by HGNC
Primary source: HGNC:HGNC:8154
See related: Ensembl:ENSG00000082556 MIM:165196; AllianceGenome:HGNC:8154
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KOP; KOR; KOR1; OPRK; KOR-1; K-OR-1
Summary: This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Expression: Biased expression in brain (RPKM 1.8), prostate (RPKM 1.6) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q11.23

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (53225724..53251637, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (53602209..53628122, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (54138284..54164197, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

kappa-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-kappaB pathway.
Title: κ-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-κB pathway.
Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms.
Title: Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms.
Clustering of KOR PET images separates people with AUD into distinct responses to naltrexone.
Title: Clustering of KOR PET images separates people with AUD into distinct responses to naltrexone.
The dynorphin/kappa opioid receptor mediates adverse immunological and behavioral outcomes induced by repetitive blast trauma.
Title: The dynorphin/kappa opioid receptor mediates adverse immunological and behavioral outcomes induced by repetitive blast trauma.
Opioids in cancer: The kappaopioid receptor (Review).
Title: Opioids in cancer: The κ‑opioid receptor (Review).
Analyses of polymorphisms of intron 2 of OPRK1 (kappa-opioid receptor gene) in association with opioid and cocaine dependence diagnoses in an African-American population.
Title: Analyses of polymorphisms of intron 2 of OPRK1 (kappa-opioid receptor gene) in association with opioid and cocaine dependence diagnoses in an African-American population.
Activation of kappa-opioid receptor inhibits inflammatory response induced by sodium palmitate in human umbilical vein endothelial cells.
Title: Activation of κ-opioid receptor inhibits inflammatory response induced by sodium palmitate in human umbilical vein endothelial cells.
Haplotype-based association study of Opioid Receptor Kappa-type 1 (OPRK1) gene polymorphisms with nicotine dependence among male smokers.
Title: Haplotype-based association study of Opioid Receptor Kappa-type 1 (OPRK1) gene polymorphisms with nicotine dependence among male smokers.
Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography.
Title: Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography.
Occupancy of the kappa opioid receptor by naltrexone predicts reduction in drinking and craving.
Title: Occupancy of the kappa opioid receptor by naltrexone predicts reduction in drinking and craving.

Submit: New GeneRIF Correction See all GeneRIFs (97)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of total serum and mite-specific IgEs in asthma patients. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Kappa-opioid receptor (KOR) agonist treatment of CD4(+) lymphocytes inhibits HIV-1 envelope gp120/41-mediated membrane fusion via downregulation of CXCR4	PubMed
Tat	tat	Morphine treatment in the presence of Tat significantly increases intracellular expression of opioid receptors (mu, delta, and kappa) and prevents morphine-induced cell surface opioid receptor down-regulation in microglia	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH70574 (e-PCR)
- UniSTS:87561

NoName (e-PCR)
- UniSTS:481317

OPRK1_3342 (e-PCR)
- UniSTS:462381

D8S2279 (e-PCR)
- UniSTS:473907

STS-R31938 (e-PCR)
- UniSTS:65357

RH66816 (e-PCR)
- UniSTS:69742

D15S1477 (e-PCR)
- UniSTS:474482

D11S3114 (e-PCR)
- UniSTS:152207

A006N31 (e-PCR)
- UniSTS:51862

NoName (e-PCR)
- UniSTS:490441

RH92303 (e-PCR)
- UniSTS:86494

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled opioid receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables dynorphin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables dynorphin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables dynorphin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor serine/threonine kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled opioid receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled opioid receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-inhibiting opioid receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in behavioral response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	TAS Traceable Author Statement more info	PubMed
involved_in conditioned place preference	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in eating behavior	IEA Inferred from Electronic Annotation more info
involved_in estrous cycle	IEA Inferred from Electronic Annotation more info
involved_in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in locomotory behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in maternal behavior	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of luteinizing hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dopamine secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of eating behavior	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of p38MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of saliva secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to acrylamide	IEA Inferred from Electronic Annotation more info
involved_in response to estrogen	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
involved_in response to nicotine	IEA Inferred from Electronic Annotation more info
involved_in sensory perception	TAS Traceable Author Statement more info	PubMed
involved_in sensory perception of pain	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of pain	ISS Inferred from Sequence or Structural Similarity more info
involved_in sensory perception of temperature stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in T-tubule	IEA Inferred from Electronic Annotation more info
located_in axon terminus	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kappa-type opioid receptor

Names: Opiate receptor, kappa-1; kappa opioid receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000912.5 → NP_000903.2 kappa-type opioid receptor isoform 1

See identical proteins and their annotated locations for NP_000903.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon (nt . This RefSeq represents the shorter isoform (1).

Source sequence(s)

AK023198, AY466378, BC099912, DA264471, U17298

Consensus CDS

CCDS6152.1

UniProtKB/Swiss-Prot

E5RHC9, P41145, Q499G4

UniProtKB/TrEMBL

B2R7P1

Related

ENSP00000265572.3, ENST00000265572.8

Conserved Domains (1) summary

cd15091
Location:60 → 341

7tmA_Kappa_opioid_R; opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001282904.2 → NP_001269833.1 kappa-type opioid receptor isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an additional exon in the mid-region, which results in translation initiation at an in-frame downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC009646, AK310407, BF061371

Consensus CDS

CCDS64895.1

UniProtKB/Swiss-Prot

P41145

Related

ENSP00000430923.1, ENST00000524278.5

Conserved Domains (1) summary

pfam00001
Location:1 → 241

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_001318497.2 → NP_001305426.1 kappa-type opioid receptor isoform 1x

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.

Source sequence(s)

AK023198, AY466378, BC099912, DA264471, U17298

Consensus CDS

CCDS94292.1

UniProtKB/TrEMBL

A0A5F9ZI09, B2R7P1

Related

ENSP00000500765.2, ENST00000673285.2

Conserved Domains (2) summary

pfam00001
Location:76 → 330

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:71 → 271

7tm_4; Olfactory receptor