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    ZNF141 zinc finger protein 141 [ Homo sapiens (human) ]

    Gene ID: 7700, updated on 5-May-2024

    Summary

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    Official Symbol
    ZNF141provided by HGNC
    Official Full Name
    zinc finger protein 141provided by HGNC
    Primary source
    HGNC:HGNC:12926
    See related
    Ensembl:ENSG00000131127 MIM:194648; AllianceGenome:HGNC:12926
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    D4S90; pHZ-44
    Summary
    The protein encoded by this gene is a zinc finger protein that may be a tumor suppressor. Defects in this gene have been associated with autosomal recessive postaxial polydactyly type A. [provided by RefSeq, Jan 2017]
    Expression
    Ubiquitous expression in adrenal (RPKM 3.7), lymph node (RPKM 3.5) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    4p16.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (337814..384868)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (331204..378261)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (331603..378657)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 732 Neighboring gene uncharacterized LOC105374336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15097 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:330727-331242 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:331348-332308 Neighboring gene microRNA 571 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:388927-389606 Neighboring gene zinc finger protein 519 pseudogene 4 Neighboring gene HERV-FRD provirus ancestral Env polyprotein pseudogene Neighboring gene ATP binding cassette subfamily A member 11, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Whole exome sequencing identified a novel zinc-finger gene ZNF141 associated with autosomal recessive postaxial polydactyly type A. Kalsoom UE, et al. J Med Genet, 2013 Jan. PMID 23160277
    2. A zinc-finger gene ZNF141 mapping at 4p16.3/D4S90 is a candidate gene for the Wolf-Hirschhorn (4p-) syndrome. Tommerup N, et al. Hum Mol Genet, 1993 Oct. PMID 8268908
    3. hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer. Varrault A, et al. Proc Natl Acad Sci U S A, 1998 Jul 21. PMID 9671765, Free PMC Article
    4. Advances in the molecular genetics of non-syndromic polydactyly. Deng H, et al. Expert Rev Mol Med, 2015 Oct 30. PMID 26515020
    5. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. Vissing H, et al. FEBS Lett, 1995 Aug 7. PMID 7649249

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Polydactyly, postaxial, type A6
    MedGen: C3808889 OMIM: 615226 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 141
    Names
    zinc finger protein 141 (clone pHZ-44)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052984.2 RefSeqGene

      Range
      5002..52056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001348277.2 → NP_001335206.1  zinc finger protein 141 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate exons compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC079140, AC092574
      UniProtKB/TrEMBL
      Q4W5N2
      Conserved Domains (3) summary
      COG5048
      Location:42 → 338
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:315 → 395
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:209 → 229
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001348278.2 → NP_001335207.1  zinc finger protein 141 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC079140, AC092574
      Consensus CDS
      CCDS87195.1
      UniProtKB/TrEMBL
      D6RIY0
      Related
      ENSP00000425799.1, ENST00000512994.5
      Conserved Domains (1) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box

    3. NM_001348279.2 → NP_001335208.1  zinc finger protein 141 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC079140
      Conserved Domains (1) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box

    4. NM_001348280.2 → NP_001335209.1  zinc finger protein 141 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC079140
      Conserved Domains (1) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box

    5. NM_003441.4 → NP_003432.1  zinc finger protein 141 isoform 1

      See identical proteins and their annotated locations for NP_003432.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC079140, AC092574
      Consensus CDS
      CCDS33931.1
      UniProtKB/Swiss-Prot
      Q15928, Q6DK07
      Related
      ENSP00000240499.7, ENST00000240499.8
      Conserved Domains (5) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box
      COG5048
      Location:118 → 414
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:285 → 305
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:297 → 322
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      337814..384868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416147.1 → XP_047272103.1  zinc finger protein 141 isoform X3

    2. XM_017008591.3 → XP_016864080.1  zinc finger protein 141 isoform X1

    3. XM_011513562.4 → XP_011511864.1  zinc finger protein 141 isoform X2

      Conserved Domains (5) summary
      smart00349
      Location:64 → 103
      KRAB; krueppel associated box
      COG5048
      Location:146 → 442
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:313 → 333
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:64 → 103
      KRAB; KRAB box
      pfam13465
      Location:325 → 350
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      331204..378261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350814.1 → XP_054206789.1  zinc finger protein 141 isoform X3

    2. XM_054350812.1 → XP_054206787.1  zinc finger protein 141 isoform X1

    3. XM_054350813.1 → XP_054206788.1  zinc finger protein 141 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15928.1 GenPept UniProtKB/Swiss-Prot:Q15928

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