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    SIRT3 sirtuin 3 [ Bos taurus (cattle) ]

    Gene ID: 614027, updated on 6-Jun-2024

    Summary

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    Official Symbol
    SIRT3provided by VGNC
    Official Full Name
    sirtuin 3provided by VGNC
    Primary source
    VGNC:VGNC:34632
    See related
    BGD:BT15349; Ensembl:ENSBTAG00000002044
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SIRT3 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (82879493..82902823, complement)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene NBAS subunit of NRZ tethering complex Neighboring gene Bet1 golgi vesicular membrane trafficking protein like Neighboring gene RIC8 guanine nucleotide exchange factor A Neighboring gene proteasome 26S subunit, non-ATPase 13 Neighboring gene cytochrome c oxidase subunit VIII-H (heart/muscle)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic variants in SIRT3 transcriptional regulatory region affect promoter activity and fat deposition in three cattle breeds. Gui L, et al. Mol Cell Probes, 2017 Apr. PMID 27979739
    2. Detection of Insertions/Deletions Within SIRT1, SIRT2 and SIRT3 Genes and Their Associations with Body Measurement Traits in Cattle. Jin Y, et al. Biochem Genet, 2018 Dec. PMID 29869077
    3. Haplotype distribution in the class I sirtuin genes and their associations with ultrasound carcass traits in Qinchuan cattle (Bos taurus). Gui L, et al. Mol Cell Probes, 2015 Jun. PMID 25839883
    4. Bovine sirtuins: initial characterization and expression of sirtuins 1 and 3 in liver, muscle, and adipose tissue. Ghinis-Hozumi Y, et al. J Anim Sci, 2011 Aug. PMID 21421831
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sirtuin 3 mitigates oxidative-stress-induced apoptosis in bovine mammary epithelial cells.
      Title: Sirtuin 3 mitigates oxidative-stress-induced apoptosis in bovine mammary epithelial cells.
    2. the novel 12-bp indel of SIRT1 gene, the 7-bp indel of SIRT2 gene and the 26-bp indel of SIRT3 gene were firstly reported, respectively. The association analysis indicated that the indels within SIRT1 and SIRT2 genes were significantly associated with body measurement traits such as body weight, chest circumference, height at hip cross, hip width, body height, etc.
      Title: Detection of Insertions/Deletions Within SIRT1, SIRT2 and SIRT3 Genes and Their Associations with Body Measurement Traits in Cattle.
    3. The results indicate that the polymorphisms in transcription factor binding sites of SIRT3 promoter may affect the transcriptional activity of SIRT3, and thus alter intramuscular fat content in beef cattle.
      Title: Genetic variants in SIRT3 transcriptional regulatory region affect promoter activity and fat deposition in three cattle breeds.
    4. The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
      Title: Haplotype distribution in the class I sirtuin genes and their associations with ultrasound carcass traits in Qinchuan cattle (Bos taurus).
    5. The expression profile of sirtuin 1 and sirtuin 3 in the liver, muscle, and adipose tissue of calves and bulls is reported.
      Title: Bovine sirtuins: initial characterization and expression of sirtuins 1 and 3 in liver, muscle, and adipose tissue.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables NAD-dependent histone deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NAD-dependent protein deacetylase sirtuin-3, mitochondrial
    NP_001193598.1
    XP_005200990.1
    XP_010799033.1
    XP_024854891.1
    XP_059747449.1
    XP_059747450.1
    XP_059747451.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206669.1 → NP_001193598.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial

      See identical proteins and their annotated locations for NP_001193598.1

      Status: VALIDATED

      Source sequence(s)
      BC149729, EV693057
      UniProtKB/TrEMBL
      A0AAA9TDT4, G5E521
      Related
      ENSBTAP00000002648.3, ENSBTAT00000002648.5
      Conserved Domains (1) summary
      cd01408
      Location:71 → 306
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      82879493..82902823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024999123.2 → XP_024854891.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X2

      Conserved Domains (1) summary
      cd01408
      Location:1 → 231
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

    2. XM_010800731.4 → XP_010799033.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X2

      Conserved Domains (1) summary
      cd01408
      Location:1 → 231
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

    3. XM_005200933.5 → XP_005200990.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl00195
      Location:71 → 252
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    4. XM_059891467.1 → XP_059747450.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X2

    5. XM_059891468.1 → XP_059747451.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X4

    6. XM_059891466.1 → XP_059747449.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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